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『BICCN column』Nature Type-specific classification of mouse motor neuron cortex
Time of Update: 2021-12-28
The Lior Pachter research group of California Institute of Technology in the BICCN consortium published a paper entitled Isoform cell-type specificity in the mouse primary motor cortex, which revealed the resolution of genotype subtypes through SMART-seq [1] and the combination with spatial transcriptome technology.
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Neuron: Cao Peng/Ma Yuanwu/Zhang Fan joint team reveals self-modified closed-loop motor neural circuit
Time of Update: 2021-12-28
Researchers use viruses to specifically activate the spinal cord to receive Sp5C Cbln2 neuronal input (spinal←Sp5C Cbln2 loop), which can cause self-modification-like forelimb movement, inhibiting the neural circuit can hinder corn oil or plantar electric shocks.
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Nanjing Normal University Qian Yong: New Ideas for Chemical Control of Epilepsy, Cell Press Dialogue with Scientists
Time of Update: 2021-12-28
Professor Qian Yong’s team combined a new type of ferrous ion (Fe2+) fluorescent probe with high-throughput imaging technology to screen the lead compound dihydroartemisinin (DHA), revealing that it can alleviate the iron homeostasis of nerve cells The epileptic state of mice .
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Cell Research Liu Zhijie/Hua Tian team reveals the signal transduction mechanism of GPR139, a schizophrenia target
Time of Update: 2021-12-28
The mechanism of recessive symptoms of anti-schizophrenia and the safety of opioids have always been scientific issues that need to be resolved urgently . The orphan receptor GPR139 is a highly expr
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Radiology: Patients with COVID-19 infection have persistent white matter microstructure changes after one year of recovery
Time of Update: 2021-12-27
Finally, in a shorter hospital stay and a longer follow-up time, they tend to exhibit less white matter abnormalities after one year of rehabilitation of COVID-19 V ic value lower than HCs .
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Stroke: In the general population, what is the difference between the risk factors for old or new cerebral infarction?
Time of Update: 2021-12-27
assessed the relationship between prevalence and eventual cerebral infarction in subcortical, cortical, and cerebellar regions identified by MRI and risk factors for blood vessels , arteriosclerosis, and embolism .
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Nat Neurosci: Fight poison with poison, the deadly anthrax toxin can be used to eliminate pain
Time of Update: 2021-12-27
, Nature Neuroscience journal published a report entitled: Anthrax Toxins The Regulate Pain Signaling and Molecular CAN The deliver cargoes INTO ANTXR2 + DRG neurons & Sensory research papers .
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons .
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Stroke: Young people’s stroke risk factors may vary depending on race
Time of Update: 2021-12-27
Among black patients and white patients, the prevalence, odds, and population attributable risk percentage (PAR%) of smoking, diabetes, and hypertension were determined by gender stratification .
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Craniocerebral anatomy formula
Time of Update: 2021-12-27
Craniocerebral anatomy formula:Craniocerebral anatomy formula: Craniocerebral anatomy formula: Craniocerebral anatomy formula:One section, one ring, three bodies, two capsulesOne section, one ring, th
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Neurology: Chronic inflammation leads to cognitive changes in brain aging, DNA methylation is a potential biomarker
Time of Update: 2021-12-26
By comparing epigenetic and serum C-reactive protein biomarkers and their relationship with neuroimaging and cognitive results, the relationship between chronic inflammation and cognitive aging is studied .
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Common imaging diagnosis of lateral ventricle space
Time of Update: 2021-12-26
The anterior horn of the right lateral ventricle occupies, T1WI shows a little low signal, T2WI shows a little high signal, and the parenchymal part of the enhanced scan shows moderate enhancement Case twoCase twoMedical history and imagesMedical history and images
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140,000 people research: do it for too long and still be in vain?
Time of Update: 2021-12-26
8 years) was conducted, comparing healthy individuals (n = 112018), individuals with cardiovascular risk factors (CVRF) (n = 27982), and CVD (n = 2493) with moderate The relationship between vigorous physical activity (MVPA) and major adverse cardiovascular events (MACE) and all-cause mortality .
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Stroke: The influence of the occlusion site on the safety and efficacy of intravenous alteplase
Time of Update: 2021-12-26
In the pre-designated subgroup of this randomized trial, the researchers found no evidence that the location of the occlusion can provide intravenous alteplase for patients eligible for endovascular treatment .
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Alzheimer Dementia: Beijing Aging Mental Recovery Action-How to carry out early prevention of cognitive impairment?
Time of Update: 2021-12-26
Recent studies have shown that Alzheimer's disease (AD) is the most common dementia, and its pathological basis can be detected as early as 20 years before the appearance of obvious clinical symptoms .
Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.
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Research progress of endovascular treatment for high-risk non-acute internal carotid artery occlusion
Time of Update: 2021-12-26
Non-acute internal carotid artery occlusion (NA-ICAO) currently includes conservative medication, bypass surgery, carotid endarterectomy (CEA), and endovascular treatment.
The combined application of the two can more effectively improve the recanalization rate of long-segment carotid artery occlusion, and Reduce the incidence of perioperative complications .
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Tau and PQBP1: protein interaction induces inflammation in the brain
Time of Update: 2021-12-26
In a new study published in Nature Communications , researchers from Tokyo Medical and Dental University (TMDU ) revealed the role of the intracellular receptor PQBP1 in response to Tau Tau is a protein mainly found in neurons and plays a key role in the progression of neurodegenerative diseases such as Alzheimer's disease .
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JAMA Neurology: Application of Next Generation Cerebrospinal Fluid Genome Sequencing Technology in Tumor Detection
Time of Update: 2021-12-26
In non-diagnostic cytology and/or flow cytometry, 64% (95% CI, 41% to 83%) of patients had aneuploidy; in neuroinflammatory disease studies, 55% ( 95%CI, 23%~83%) patients were finally diagnosed as central nervous system malignant tumors .
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Stroke: Artificial intelligence helps the diagnosis of prehospital great vessel occlusion?
Time of Update: 2021-12-26
In the study of evaluating patients with MSU in 2 cities, the ML algorithm can accurately and quickly detect LVO using pre-hospital CTA collection .
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JAMA Sub-Journal: On the basis of aspirin, ticagrelor vs. clopidogrel DAPT has no difference in the effect of treating stroke!
Time of Update: 2021-12-26
Prevent strokeIn order to compare the effects of ticagrelor and aspirin with clopidogrel and aspirin in the prevention of recurrent stroke or death in patients with acute minor ischemic stroke or TIA, experts from the School of Epidemiology and Public Health of the University of Ottawa in Canada conducted a study The meta-analysis, and the results were published in the journal JAMA Neurology .
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Imaging diagnosis of facial nerve
Time of Update: 2021-12-26
Business (WeChat): fsslong4 Author: Xian Junfang Wang Zhenchang First Release : Head and Neck Medical Imaging Alliance Thanks to Professor Xian Junfang and Professor Wang Zhenchang for their wonderful
