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Stroke: The influence of the occlusion site on the safety and efficacy of intravenous alteplase

 Last Update: 2021-12-26
 Source: Internet
 Author: User

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Recent experiments have shown that suitable for intravenous alteplase and blood vessels within the thrombus resection of the anterior circulation large vessel occlusion patient, individual treatment thrombectomy with the bridge considerably
.

Vascular Thrombosis

Recently, a research article was published in Stroke, an authoritative journal in the field of cardiovascular disease.
In this study, researchers aimed to evaluate whether the occlusion site would change the effect of intravenous injection of alteplase before thrombectomy
.

This is a pre-determined subgroup analysis of a randomized trial that assessed the risks and benefits of intravenous alteplase before thrombectomy
.

Among 658 randomized patients, 640 patients with baseline occlusion location information were included

Stroke

Compared with combination therapy, the overall adjusted common odds ratio of thrombectomy alone was 1.
08 (95% CI 0.
82-1.
43), and there was no significant interaction between treatment and occlusion site (P=0.
47)
.

In a subgroup based on the location of the occlusion, the researchers found an adjusted common odds ratio: internal carotid artery occlusion was 0.

It can be seen that in the pre-designated subgroup of this randomized trial, the researchers found no evidence that the occlusion position can provide intravenous alteplase for patients eligible for endovascular treatment
.

In the pre-designated subgroup of this randomized trial, the researchers found no evidence that the location of the occlusion can provide intravenous alteplase for patients eligible for endovascular treatment
.

Original source:

Yu Zhou.

Effect of Occlusion Site on the Safety and Efficacy of Intravenous Alteplase Before Endovascular Thrombectomy: A Prespecified Subgroup Analysis of DIRECT-MT in this message

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