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The Lancet: Of 57 major diseases, 16 are associated with smaller total brain volume!

 Last Update: 2022-05-26
 Source: Internet
 Author: User

Individual disease and brain volume

Of the 57 major disorders, 16 were associated with smaller total brain volume, 14 were associated with smaller gray matter volume, 6 were associated with smaller hippocampal volume, and four major disorders were associated with higher white matter height adjusted for all other disorders Signal (WMH) load correlation

Multimorbidity and Brain Volume

Multiple-morbidity patterns were identified using the six-class model that yielded the lowest CAIC (19, 118 3)

All other patterns were associated with smaller total brain, gray matter and hippocampus volumes and higher WMH load compared with the relatively healthy multimorbid pattern

Multimorbidity, defined by the number of major diseases, was associated with smaller total brain, gray matter and hippocampal volumes and larger WMH volumes

Higher multimorbidity scores were associated with smaller total brain, gray matter and hippocampus and higher WMH load

Higher multimorbidity scores were associated with smaller total brain, gray matter and hippocampus and higher WMH load
.
The variance of total brain volume explained by the multimorbidity score was 0.
0537 ( Table 4 )
.
In a multivariate adjusted analysis (Model 3), the coefficients for total brain, gray matter, hippocampus, and WMH volume associated with each standard deviation increment of the multimorbidity score were -2 6 (-3 3, -2 0) ml, −3 2 (−3 6, −2 8) ml, −12.
6 (−17 1, −8 1) μl and 0.
10 (0 09, 0.
11) ml ( Table 4 )
.

Taken together, this study found that obesity, diabetes, high blood pressure, high cholesterol and depression were associated with smaller brain volume
.
In addition to these conventional diseases, CVD (heart failure, atrial fibrillation, other heart diseases and peripheral vascular disease), mental/psychiatric disorders (alcohol problems, psychoactive substance abuse and schizophrenia), chronic obstructive pulmonary disease (COPD), CKD , breast cancer, rectal cancer and some eye diseases were associated with smaller brain volumes independently of all other diseases
.
The multi-morbidity pattern associated with CMD may pose a risk of brain volume loss
.
The associations between multimorbidity and brain volume were stronger in men than in women, stronger in younger people than in older people, and stronger in those with less education than those with higher education
.

In all, this study identified more than 20 known and emerging disorders associated with smaller brain size
.
The multimorbid pattern associated with CMD is associated with a reduction in brain volume
.
Both the multi-morbidity and multi-morbidity scores, defined by the number of diseases, strongly predicted brain volume
.
Men or young adults with multi-morbidity need more care to prevent brain volume loss
.

Original source:

Xianwen Shang, et al.
Association of a wide range of individual chronic diseases and their multimorbidity with brain volumes in the UK Biobank: A cross-sectional study.
eClinicalMedicine 2022;47: 101413 Published online xxx https://doi.
org/10.
1016 /j.
eclinm.
2022.
101413

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