-
Nat Neurosci He Yanlin/Xu Yong team discovered and revealed a new regulatory mechanism of anorexia nervosa
Time of Update: 2022-05-28
The research team then used chemogenetics to selectively inhibit the DAVTA→5-HTDRN neural circuit and found that it partially reversed symptoms of anorexia while improving survival in mice with anorexia nervosa model .
-
Mol Psychiatry︱Hu Shaohua/Song Xueqin/Nie Chao team made new progress in the study of the brain-gut axis mechanism of bipolar disorder
Time of Update: 2022-05-28
Mol Psychiatry, 2022) The α-diversity of gut microbes in the BD patient group decreased, while the β-diversity increased, and the structural composition and functional characteristics were also changed, mainly manifested as Streptococcaceae and Bacteroidaceae The abundance levels of Akkermansia muciniphila and Faecalibacterium prausnitzii decreased, and there were also significant intergroup differences in metabolic pathways involving amino acid metabolism and vitamin synthesis, suggesting that BD depressive episodes have gut microbial disturbances (Fig.
-
Nature: These immune cells are all over the brain, and their origin and function have just been discovered…
Time of Update: 2022-05-28
Using cutting-edge single-cell analysis techniques, cell fate tracking, and cell-specific transgenic mouse models, the researchers labelled different types of brain macrophages and their progenitors to confirm these Specialized macrophages and microglia distributed in the meninges, blood vessels, etc.
-
PNAS Liu Chunqiao's team reveals a new mechanism for protein transport in the outer segment of photoreceptors
Time of Update: 2022-05-28
Recently, Chunqiao Liu from Zhongshan Ophthalmology Center of Sun Yat-sen University jointly published a research paper Tmem138 is localized to the connecting cilium essential for rhodopsin localization and outer segment biogenesis in PNAS, Proceedings of the National Academy of Sciences .
-
"Posting is human nature" mechanism found!
Time of Update: 2022-05-28
Until recently, a study published in Science revealed the important role of the PROK2-PROKR2 neural pathway in the transmission of pleasurable touch.
Defects in the PROK2-PROKR2 signaling pathway cause mice to be reluctant to engage in social contact, similar to the early behavioral characteristics of some autistic patients.
-
Neurosci Biobehav Rev︱ Hongyan Bi's research group reveals similarities and differences in neural mechanisms of dyslexia children with different writing systems
Time of Update: 2022-05-28
, Nat Revs Neurosci, 2015) Recently, Bi Hongyan's research group from the Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences published a paper entitled "Comparative research on neural dysfunction in Neuroscience & Biobehavioral Reviews" Children with dyslexia under different writing systems: A meta-analysis study", which aims to study the common and specific neural mechanisms of alphabetic language and Chinese dyslexia children .
-
Harvard scientists propose new indicator of Alzheimer's disease that can predict the time and severity of onset
Time of Update: 2022-05-28
Lei Liu and colleagues at Harvard's Brigham and Women's Hospital found that lower Aβ37/Aβ42 ratios in cerebrospinal fluid were associated with earlier onset of symptoms in familial Alzheimer's disease associated with more severe cognitive impairment in sporadic Alzheimer's disease .
-
Science Sub-Journal: Neural Circuit Mechanisms of Chronic Pain-Induced Anxiety
Time of Update: 2022-05-28
Overall, we found that chronic pain can enhance the excitability of CARTergic neurons in the ovBNST brain region of the BNST subregion, and induce anxiety-like behaviors through a local inhibitory loop regulating the adBNST → LH loop .
-
A Brief History of Facial Paralysis: From Bell's Palsy to Hunt's Syndrome
Time of Update: 2022-05-28
It is worth noting that Lacy emphasized that patients need to avoid light and rest in a dark room, which is very similar to today's treatment principles, because if the orbicularis oculi muscle is paralyzed, the eyes cannot be closed for a long time, and if the lacrimal gland secretion is blocked, it will be affected.
-
Courier crosses the blood-brain barrier, and innovative therapy for ALS enters phase 2 clinical trials
Time of Update: 2022-05-27
▎WuXi AppTec Content Team Editor Recently, Denali Therapeutics announced that its partner, Sanofi, has started a Phase 2 clinical trial to test the efficacy and safety of SAR443820 (DNL788) in the treatment of amyotrophic lateral sclerosis (ALS) .
-
Progress in the Nature Neuroscience series: CSF contributes to the construction of the immune "firewall" of the brain!
Time of Update: 2022-05-27
In general, the brain can directly flow into the skull bone marrow through the cerebrospinal fluid, and through its components play the function of recruiting and migrating immune cells to regulate its own immune response .
-
Metformin turned into a "God Assist" in the treatment of Alzheimer's disease!
Time of Update: 2022-05-27
Based on this, the research team of Yang Lichao used the interaction between host and guest molecules to prepare an Aβ-responsive dual-drug inclusion complex (MPD), which not only has superior biological stability and targeted release, but also It has synergistic anti-dementia effect by increasing the clearance rate of Aβ and inhibiting the activity of AchE .
-
STAR Protocols︱A protocol for fluorescence in vivo imaging of postembryonic development of C. elegans
Time of Update: 2022-05-27
On April 19, 2022, Zou Yan's research group from the School of Life Science and Technology, ShanghaiTech University published a research proposal paper titled "Live imaging of postembryonic developmental processes in C.
Fluorescence real-time microscopy imaging of neuronal migration and dendritic growth during postembryonic development in C.
-
Light sleep, the more you sleep, the more tired you are?
Time of Update: 2022-05-27
A recent study published in Nature Communications by researchers at Harvard Medical School provides a key clue to this long-standing mystery: they found that knocking out the GABAA alpha3 subunit on thalamic reticular neurons effectively enhanced mouse of deep sleep .
-
Express Detects Alzheimer's-Related Amyloid Deposits Early, FDA Approves First In Vitro Diagnostic Test Today
Time of Update: 2022-05-27
The Lumipulse G beta amyloid ratio (1-42/1-40) test developed by Fujirebio Diagnostics is intended for use in adult patients over the age of 55 who present with cognitive impairment and are being evaluated for Alzheimer's disease or other conditions that cause cognitive decline .
-
Gene therapy to reverse autism-related gene mutations in brain organoids and their effects on neurodevelopment
Time of Update: 2022-05-27
To study the impact of TCF4 gene mutations on brain development, the research team focused on Pitt-Hopkins syndrome, a form of autism caused by mutations in the TCF4 gene, in children with severe cognitive and motor impairments .
-
Cell Metabolism｜Bacteria + diet-induced high proline levels may be the killer of depression
Time of Update: 2022-05-27
Using data from three cohorts, combined with multi-omics analysis and experiments in mice and Drosophila, the researchers deeply explored the relationship between the microbiome and depression, revealing the role of microbiome-dependent changes in proline metabolism in depression.
-
What do people see before they die?
Time of Update: 2022-05-27
Figure 1 Zdzislaw Beksinski's paintings based on near-death memories (Source: Zdzislaw Beksinski's public works) With the continuous development of medical technology, many people who have been "dead" for a few minutes or even hours are fortunate enough to return to the world and have the opportunity to Answer a question - what kind of experience does a person experience when he is on the verge of death?
-
13 tricks to "perfect" stroke prevention!
Time of Update: 2022-05-27
2% of the stroke burden could be avoided by controlling risk factors, and stroke is a highly preventable disease!
③ For patients with non-valvular atrial fibrillation, if they are 65-75 years old and have no vascular risk factors, it is recommended to take aspirin or oral anticoagulants (INR 2.
-
Blood test for Alzheimer's disease?
Time of Update: 2022-05-27
By reanalysing mononuclear transcriptome data from multiple cohorts, the researchers observed a continuous increase in astrocyte PHGDH expression levels, either as AD pathology progressed from inception or as symptoms worsened .
