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Neurology: Higher baseline total tau and neurofilament light chains in plasma are associated with higher stroke risk

 Last Update: 2022-05-25
 Source: Internet
 Author: User

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Stroke and dementia are common neurological disorders in the elderly and often co-occur in the same patient

To clarify whether Alzheimer's disease-related pathology or neurodegeneration plays a role in stroke etiology, the effects of plasma β- amyloid (Aβ) , total tau , and neurofilament light chain (NfL) levels on stroke and stroke were determined .

Between 2002 and 2005 , the research team measured plasma Aβ40 _, Aβ42 , total _tau and NfL in 4661 stroke-free participants in Rotterdam .

Between 2002 and 2005 , the research team measured _plasma Aβ4040 , _Aβ4242 , total tau and _NfLin 4661 stroke-free participants in _Rotterdam.

The study found:

After a mean follow-up of 10.

Association of plasma _Aβ40 , Aβ42 , total Tau and _NfL with stroke risk

_{Association of}plasma Aβ40 , Aβ42 , total Tau and _NfLwith stroke risk ₄₀₄₂

Baseline Total Baseline Total tau and NfL and NfL Participants with higher risk of stroke and several stroke subtypes were at higher risk of stroke and several stroke subtypes .

original source

Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study.

Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study.
Neurology Apr 2022, 98 (17) e1729-e1737; DOI: 10.
1212/WNL.
0000000000200004 Plasma β-Amyloid , Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study.
Neurology Apr 2022, 98 (17) e1729-e1737; DOI: 10.
1212/WNL.
0000000000200004

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