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In a new study, researchers from research institutions including the German Centre for Cardiovascular Research, the University of Munich, the University of Rome I, and the IRCCS Institute in Italy have found a link between atherosclerotic plaques and the central nervous system.
In a new study, researchers from research institutions including the German Centre for Cardiovascular Research, the University of Munich, the University of Rome I, and the IRCCS Institute in Italy have found a link between atherosclerotic plaques and the central nervous system.
Plaques composed of accumulation of cholesterol , fibrous tissue, and immune cells are typical features of atherosclerosis
Plaques composed of accumulation of cholesterol , fibrous tissue, and immune cells are typical features of atherosclerosis
The new study looked at experimental models and human tissues
Co-author Professor Daniela Carnevale, from the Department of Vascular Neurology and Translational Medicine at the IRCCS Institute, said: "When there is atherosclerotic plaque, aggregates of immune cells also accumulate in the outer connective tissue of blood vessels -- called arteries.
The authors reconstructed the entire pathway from nerve fibers to the central nervous system
Atherosclerosis-associated axonal neogenesis in ATLO
Atherosclerosis-associated axonal neogenesis in ATLO
This is a real circuit, and these are called artery-brain circuits (ABC)
Considering that atherosclerotic plaque stability is one of the most clinically relevant features for assessing disease severity, and in this study, components of the ABC were also present in isolated atherosclerotic human arteries were identified, so these findings have very important translational potential
Co-author Professor Giuseppe Lembo, Head of the Department of Vascular Neurology and Translational Medicine at the IRCCS Institute, said, "This is a fresh perspective that paves the way for new curricula and previously unforeseen treatment strategies
References:
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Atherosclerotic plaques 'talk' with the brain
https://medicalxpress.
com/news/2022-04-atherosclerotic-plaques-brain.
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