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A 21-year-old man with daily episodes of sexual changes in consciousness, why?
Time of Update: 2022-03-09
In this patient, transient cerebral hypoperfusion due to syncope/presyncope should be considered given the visual and sensory disturbances and brief duration of TAA onset, but syncope is usually accompanied by abnormal motor activity .
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Nat Neurosci︱VTA dopaminergic neurons are involved in encoding social prediction error and social reinforcement learning
Time of Update: 2022-03-09
Written by ︱ Nie Lutunan Editor ︱ Sizhen Wang Whether it is a rodent or a human, social behavior means cooperation among the same species, and cooperation is beneficial to avoid predators . Most soc
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Non-viral delivery technology + gene editing: Sarepta collaborates to develop innovative neuromuscular disease therapy Maimeng
Time of Update: 2022-03-09
Preliminary trial results from a collaboration between Sarepta and GenEdit have demonstrated the potential of polymer nanoparticles to deliver therapeutics to specific muscle tissues following systemic administration, allowing targeted gene drug delivery independent of viral vectors .
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PNAS︱Chun Han's group reveals a new mechanism of neuronal degeneration caused by external phagocytosis
Time of Update: 2022-03-09
Here, in order to explore whether PS valgus is regulated by the WD pathway, the authors used high-intensity lasers to damage dendrites of Sarm knockout neurons and Nmnat fusion protein WldS-overexpressing neurons, respectively, and found that PS valgus on damaged dendrites Both phenomena and debris-like changes were suppressed (Fig.
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Why do you need to sleep?
Time of Update: 2022-03-09
The study provides a detailed explanation of why sleep is needed at the single-cell level: During wakefulness, the accumulation of DNA damage in neurons increases sleep stress, and a protein called Parp1 senses this increasing DNA damage stress , and issue a sleep signal .
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Analysis of the etiology of acute bilateral cerebellar infarction, this article explains it thoroughly
Time of Update: 2022-03-09
Figure 3 (Photo source Professor Zhang Xiongwei PPT) Gaida-Hoernick[6] et al confirmed a case of bilateral symmetric cerebellar hemisphere infarction caused by occlusion of the common trunk segment of the posterior inferior cerebellar artery originating from the common trunk by DSA and CTA for the first time.
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Express Oral Alzheimer's Therapy Phase 2 Results Positive, Significantly Improved Biomarker Levels
Time of Update: 2022-03-09
▎WuXi AppTec Content Team Editor Alzheon announced today that its oral therapy ALZ-801 (valiltramiprosate) for the treatment of patients with early Alzheimer's disease has achieved positive biomarker results in a Phase 2 clinical trial .
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Neuron: The beloved son of his parents has far-reaching plans!
Time of Update: 2022-03-09
Further whole-brain c-FOS neuron activity labeling technology revealed the preoptic area, suprachiasmatic nucleus, zona indeterminate area, amygdala, ventrolateral area The periaqueductal gray matter and the reticular structure of the brainstem can satisfy the above two conditions at the same time, and become the downstream target brain regions for CART-positive neurons in the EA region to regulate nesting behavior .
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Voice of China: What is the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with moderate defect?
Time of Update: 2022-03-09
Endovascular therapy (EVT) compared with standard medical therapy (SMT) alone in patients with acute basilar artery occlusion and moderate functional impairment (National Institutes of Health Stroke Scale [NIHSS] score of 10-20) How effective and safe they are is not yet known .
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Clearing senescent stem cells from the brain enhances neurogenesis and cognitive function
Time of Update: 2022-03-09
In this study, the research team tested the negative impact of increased aging in the neural stem cell niche (Stem cell niche) on normal stem cell function and adult neurogenesis in middle-aged mouse brains .
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Courier for Huntington's disease, innovative gene therapy expands clinical development
Time of Update: 2022-03-09
▎WuXi AppTec's content team editor, uniQure, today announced that its investigational gene therapy AMT-130 for Huntington's disease has been dosed in the first two patients in a Phase 1b/2 clinical trial in Europe .
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Rare disease ushered in a new milestone!
Time of Update: 2022-03-09
February 9, 2022 / eMedClub News / -- Recently, Astellas announced positive interim data from a Phase 1/2 clinical trial of its AAV gene replacement therapy AT845, which provides functional alpha-glucosidase ( GAA) gene for the treatment of late-onset Pompe disease (LOPD) .
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Use of the Dizziness/Vertigo Scale, Super-Comprehensive
Time of Update: 2022-03-09
Currently commonly used dizziness/vertigo-related scales include assessment of vertigo severity, assessment of disability or quality of life in patients with vertigo, comprehensive assessment of vertigo, assessment of vertigo combined with mental and psychological disorders, assessment of fall risk in patients with dizziness, and diagnosis of vestibular disease.
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Chinese Voice: What is the effect of collateral circulation compensation on endovascular treatment of basilar artery occlusion?
Time of Update: 2022-03-09
The effect of collateral circulation compensation on endovascular therapy (EVT) for basilar artery occlusion (BAO) is currently unclear .
STUDY INTRODUCTION Eligible participants with a composite collateral score collected in the Endovascular Treatment of Acute Basilar Artery Occlusion Study were included in the study .
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Nature Wang Jing's team discovered the underlying molecular mechanism of "satiated food and lustful desires"
Time of Update: 2022-03-08
Here, the study explores the context in which priorities between feeding and courtship are determined and addresses the molecular and neuronal mechanisms that facilitate the transition from feeding to courtship in Drosophila .
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PPPD 1: Persistent Posture-Perceived Dizziness Has Three Subtypes
Time of Update: 2022-03-08
Figure 3 Three subtypes of PPPD and their corresponding exacerbating factors 03Third Step: Demographic and clinical characteristics What is the use of finding subtypes of PPPD?
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Nature Bread or Love?
Time of Update: 2022-03-08
This enteric neuropeptide, Diuretic hormone 31 (Dh31), is induced and released by amino acids in food and acts on two independent neural pathways in two brain regions that express Dh31 receptors, shutting down the neural pathways that control feeding behavior, and at the same time Open the neural pathway of courtship behavior and realize fast behavior switching .
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Courier to treat common Alzheimer's disease, $64 million to help develop potential 'first-in-class' therapy
Time of Update: 2022-03-08
Retrieved February 10, 2022, from https:// arkuda-bags-64m-to-test-drug-frontotemporal-dementia-2023[2] ARKUDA THERAPEUTICS RAISES $64 MILLION SERIES B FINANCING TO ADVANCE PIPELINE OF PROGRAMS TARGETING LYSOSOMAL BIOLOGY TO TREAT NEURODEGENERATIVE DISEASES.
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NIHSS scoring in practice: limb movement and ataxia, listen to what the experts say?
Time of Update: 2022-03-08
In the NIHSS score, the range of the upper and lower limb movements on each side is 0-4 points, and the letter X (the domestic record number 9) is recorded in special cases, as shown in Figure 1 .
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Voice of China: What is the 5-year outcome of endovascular treatment for acute ischemic stroke with large vessel occlusion?
Time of Update: 2022-03-08
CONCLUSIONS: This study shows that patients with acute anterior circulation LVO who received EVT mostly had good outcomes after 5 years, but the mortality and stroke recurrence rates were also higher .
