Voice of China: What is the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with moderate defect?

Endovascular therapy (EVT) compared with standard medical therapy (SMT) alone in patients with acute basilar artery occlusion and moderate functional impairment (National Institutes of Health Stroke Scale [NIHSS] score of 10-20) How effective and safe they are is not yet known
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To explore the efficacy and safety of EVT and SMT in patients with acute basilar artery occlusion and moderate functional impairment, the first author of this study is Huang Jiacheng
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The findings were presented as a poster abstract at the International Stroke Congress 2022 (ISC 2022)
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The author of this article: Yimaitong ISC report group compiled and organized by Yimaitong, please do not reprint without authorization
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Research Introduction The BASILAR study is a multi-center clinical registration study jointly carried out by the clinical research team of Professor Yang Qingwu, director of the Department of Neurology at the Second Affiliated Hospital of Army Medical University (Chongqing Xinqiao Hospital), and 47 hospitals in 15 provinces, municipalities and autonomous regions across the country
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Based on NIHSS scores, the researchers divided patients from the BASILAR (Endovascular Treatment of Acute Basilar Artery Occlusion) study into three groups, including those with mild deficits (NIHSS score <10), those with moderate deficits (NIHSS score 10-20).
) patients and patients with severe deficits (NIHSS score > 20)
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Patients with moderate deficits were then divided into two groups for analysis: EVT group and SMT-only group
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The primary efficacy outcome was favorable functional outcome (modified Rankin Scale score of 0-3) at 90 days, and the safety outcome was symptomatic intracerebral hemorrhage and mortality at 90 days
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 Main findings: ➤ A total of 194 patients had moderate deficits, 47 of whom received SMT alone and 147 who received EVT
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 ➤ The proportion of patients receiving EVT with a 90-day modified Rankin Scale score ≤3 was significantly higher compared with patients in the SMT-only group (adjusted OR, 3.
36 [95% CI, 1.
14-9.
92]; P=0.
028), but There was no statistically significant difference in 90-day mortality (adjusted OR, 0.
53 [95% CI, 0.
25-1.
14]; P=0.
10), although the incidence of symptomatic intracerebral hemorrhage was higher (4 of 146 patients [2.
7] %] vs 0 [0%] of 47 patients)
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 Conclusions This study suggests that EVT may be associated with better functional outcomes in patients with acute basilar artery occlusion and moderate functional impairment
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More randomized clinical trials are needed to confirm this result in the future
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 Yimaitong compiled from: Outcome Of Endovascular Treatment For Acute Basilar Artery Occlusion With Moderate Deficit.
ISC 2022.