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FDA approves donepezil transdermal patch for Alzheimer's disease
Time of Update: 2022-04-21
The patch stabilizes and slows donepezil, while the transdermal system delivers the drug through the skin at regular intervals, reducing adverse effects associated with gastrointestinal absorption .
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JNNP: A study of acute ischemic stroke associated with SARS-CoV-2 infection
Time of Update: 2022-04-21
Modified Rankin ScaleGrotta bar mRS scores were: (A) age-based total sample size; COVID-19 severity; and (C) hypercoagulable status .
COVID-19 ThrombosisStratified analysis of mortality using determinants of inflammation severity (NLR) and hypercoagulable state (D-dimer) For comparative analysis, three historical control groups were selected .
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JNNP: thalamic nerve stimulation improves seizure control in idiopathic generalized epilepsy
Time of Update: 2022-04-21
About 10%–40% of these patients never achieve adequate epilepsy control with medication, and generalized tonic-clonic (GTC) seizures and myoclonic seizure types increase the risk of drug resistance, with significant adverse effects on quality of life and health .
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JPD: What are the early manifestations of patients with multiple system atrophy?
Time of Update: 2022-04-21
Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study.
3233/JPD- 213039Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study.
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PNAS: Lead pollution is harming human IQ
Time of Update: 2022-04-21
In a research article titled Half of US population exposed to adverse lead levels in early childhood published in PNAS by Michael J.
In a research article titled Half of US population exposed to adverse lead levels in early childhood published in PNAS by Michael J.
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Neurology: Women's health low tide needs more attention: women with neurological comorbidities (WWN) have a higher risk of complications in first childbirth and higher readmission rates!
Time of Update: 2022-04-21
Centers for Disease Control and Prevention (CDC) Severe Maternal Morbidity Indicator (SMM) adjusted odds were higher for women with previous stroke: AOR 8.
Centers for Disease Control and Prevention (CDC) Severe Maternal Morbidity Indicator (SMM) adjusted odds were higher for women with previous stroke: AOR 8.
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JNNP: A review of cerebral cavernous malformations, a comparison of treatments
Time of Update: 2022-04-21
The aim was to clearly define (1) bleeding, (2) mortality, and (3) morbidity, as well as which sites (not only the brainstem, but also lobar, deep, and cerebellar CCMs) and whether gender and prior bleeding history were associated with bleeding risk level correlation .
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Alzheimers Dementia: Poor lung function, greatly increased risk of long-term dementia
Time of Update: 2022-04-21
To test this hypothesis, they aimed to explore(1) Association of PF with MCI risk and its progression to dementia,(2) To explore the association of PF with AD and cerebral vascular lesions using data from a long-term community cohort study, including assessment of brain pathology in participants who died during follow-up .
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Neurosurgery: Postoperative functional recovery in patients with degenerative cervical spondylotic myelopathy is associated with restoration of brain neural structures
Time of Update: 2022-04-21
Restoration of microstructural integrity of the corticospinal tract and other sensorimotor pathways, and supraspinal reorganization of microstructural connections in sensory- and motor-related regions are associated with improved neurological function after surgical decompressionoriginal sourceoriginal sourceWang C, Ellingson BM, Salamon N, Holly LT.
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Lancet: Safety and Efficacy Study of Aspirin, Unfractionated Heparin During Endovascular Stroke Treatment (MR CLEAN-MED): Increased Risk of Symptomatic Intracranial Hemorrhage, No Evidence of Beneficial Functional Outcomes!
Time of Update: 2022-04-21
guide In the current study, the Netherlands Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke (MR CLEAN-MED), investigators sought to evaluate the initiation of endovascular therapy with intravenous aspirin, unfractionated heparin, both, or neither.
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JPD: What are the characteristics of the prodromal symptoms of Parkinson's disease?
Time of Update: 2022-04-21
In the Parkinson's Risk Syndrome (PARS) study, hypoglycemic subjects had higher numbers of other nonmotor symptoms (anxiety, RBD, and constipation) than normal subjects, who were approximately 64 years old .
Prevalence of Prodromal Symptoms of Parkinson's Disease in the Late Middle-Aged Population.
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JPD: Are IQ and educational attainment related to future risk of Parkinson's disease?
Time of Update: 2022-04-21
Diagnosed higher intelligence, education, and physical height confer a higher risk of PD, independent of age at onsetIntelligence was inversely associated with mortality in men with and without PD .
3233/JPD-213102)Associations of Young Adult Intelligence, Education, Height, and Body Mass Index with Subsequent Risk of Parkinson's Disease and Survival: A Danish Cohort Study.
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JPD: Zhejiang University: Neuroimaging Assists Deep Brain Stimulation for Parkinson's Disease
Time of Update: 2022-04-21
To date, there are several methods of electrode implantation, including preoperative imaging guidance, intraoperative test-assisted microelectrode recording (MER), and methods for intraoperative computed tomography (CT) or magnetic resonance imaging (MRI) validation .
Implantation was performed by direct magnetic resonance imaging (MRI)-based localization preoperatively, with intraoperative MER and macrostimulation testing .
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JPD: Exhaled gas analysis of patients with Parkinson's disease, helpful for disease diagnosis and classification
Time of Update: 2022-04-21
Breath testing distinguishes PD patients from healthy control participants and correlates with disease stageOnline (clinic) systems showed similar results, but with lower correlations ranging from 33.
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Nutrients: How important is it to enrich the basket?
Time of Update: 2022-04-15
Age 65-79 years old, male, urban residents, higher education level, pensioner, married, living with family members, smoking, drinking alcohol, exercising regularly, wearing dentures, higher BMI, less digestive system no ADL Impairment and lower eye disease severity were predictors for the high-to-high group .
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JNNP: Development of a cerebrospinal fluid biomarker analysis method for C9orf72-related frontotemporal dementia and amyotrophic lateral sclerosis
Time of Update: 2022-04-15
An immunoassay was developed using the single-molecule array (Simoa) platform to measure the poly(GP) dipeptide repeat protein (DPR) generated by C9orf72 repeat expansion in the cerebrospinal fluid (CSF) of C9orf72-related FTD/ALS patients .
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Talking about Treatable (Reversible) Dementia Syndrome
Time of Update: 2022-03-09
Author: darkpigx Source: "I can still eat a small fish and worm" public account Before 1927, when penicillin was not invented, neurosyphilis was considered an incurable disease . But over the next f
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Repeated brain hemorrhage?
Time of Update: 2022-03-09
➤ Probable CAA-related bleeding: age = 55 years; multifocal hemorrhage limited to lobar, cortical, or subcortical (including cerebellum) by clinical presentation and findings on MRI or CT; other causes of hemorrhage excluded .
Cerebral amyloid angiopathy-related brain disease Clinical study of bleeding[J].
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[Cell Sub-Journal] Reversing memory decline?
Time of Update: 2022-03-09
com/ajcn/article/104/2/406/4564605 According to recent research from the University of Queensland, selenium - a mineral found in many foods - can reverse the effects of stroke on cognition effects and improve learning and memory in the aging brain .
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What makes Cell "defend the territory"?
Time of Update: 2022-03-09
Collectively, this study identifies differentially expressed genes in four Esr1+-expressing populations in different sexes or estrus states, as well as functional signatures of specific cell types that mediate social behavior in male or female mice .
