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How is methylcobalamin used?
Time of Update: 2022-04-21
Expert consensus on the diagnosis and treatment of diabetic neuropathy (2021 version) Recommendation: Expert consensus on the diagnosis and treatment of diabetic neuropathy (2021 version) Recommendation: consensus Mecobalamin injection 500-1000 μg/d intramuscular injection or intravenous drip for 2-4 weeks, and then given Methylcobalamin tablets 500 μg, orally three times a day, for at least 3 months .
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FDA approves GABA receptor allosteric modulator ganaxolone
Time of Update: 2022-04-21
S. Food and Drug Administration has approved Ztalmy (ganaxolone) oral suspension for the treatment of seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency (CDD) in patients over two years of age .
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Neurology: 25-year follow-up study finds cardiac structure and function associated with cognition in middle age
Time of Update: 2022-04-21
These abnormalities are common and mostly underdiagnosed ; therefore, the question of whether alterations in cardiac structure and function may be a risk factor for cognitive impairment has major public health implications and may reveal another important heart-brain connection .
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New breakthrough in "brain-computer interface"!
Time of Update: 2022-04-21
This technology uses artificial intelligence chips to be implanted in the skull, intracranial electrodes are implanted into the brain, and the EEG rhythm is monitored day and night without interruption.
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Alzheimers Dementia: A blood amyloid marker that predicts long-term dementia risk
Time of Update: 2022-04-21
In this large cohort of MCI subjects, they found a threshold for the plasma Aβ1-42/Aβ1-40 ratio that might identify patients at low risk of converting to dementia within 3 years .
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Lancet: Listening but not understanding: a case report of speech-auditory agnosia caused by brainstem lesions
Time of Update: 2022-04-21
A special condition of inability to understand language despite hearing pure tones and complete language comprehension, known as speech auditory agnosia (or word deafness) ; only speech loses meaning, possibly because of its rapidly changing acoustics The processing of the content is compromised.
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Stroke: The relationship between early childhood development and the risk of cerebrovascular disease in adults
Time of Update: 2022-04-21
The findings suggest that the timing of childhood weight gain has important implications for the development of cardiovascular disease risk in women .
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JAHA: Oral anticoagulant therapy and dementia risk in patients with atrial fibrillation
Time of Update: 2022-04-21
arrhythmia stroke _Researchers compared the incidence of dementia between oral anticoagulant (OAC) users and non-users in a large cohort of primary care patients with atrial fibrillation .
In patients with atrial fibrillation, the use of OACs may reduce the incidence of dementia compared with treatment with warfarin or no anticoagulant .
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Radiology: Preoperative brain MRI staging has no effect on prognosis in patients with stage IA asymptomatic NSCLC
Time of Update: 2022-04-21
of Seoul National University published a research article in the journal Radiology to explore whether preoperative brain MRI examination can benefit asymptomatic patients with early-stage non-small cell lung cancer .
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JPD: Parkinson's patients, depressive state predicts future neurological disorders
Time of Update: 2022-04-21
Depression and autonomic dysfunction (AuD) are common and often debilitating non-motor symptoms (NMS) of Parkinson's disease that affect more than 50% of Parkinson's patients and portend a poor prognosis .
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The magical "beard sign", you know?
Time of Update: 2022-04-21
May show uneven near-ground glass-like changes;In the early and advanced stages of the disease, the X-ray features are mainly multilocular cystic shadows with sparse trabecular bone, most of which are clearly demarcated.
Bilateral expansive multilocular cystic mass with symmetrical involvement of the mandible and maxilla
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Neuroradiology: Endovascular treatment strategies for infected aneurysms
Time of Update: 2022-04-21
C. Lateral DSA showing coil embolization of the IIA and parent artery (including the distal dilated segment):62 IIAs (30 ruptures) were diagnosed in 31 patients .
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Antioxidative effect of traditional Chinese medicine in Parkinson's disease
Time of Update: 2022-04-21
Parkinson's disease (PD) is the second progressive neurodegenerative disease and the most common chronic disease in the world after Alzheimer's disease (AD) . Neuroprotection in Traditional Chinese M
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Neurology: Unhappy after a stroke?
Time of Update: 2022-04-21
Quality of LifeTo determine sociodemographic and clinical factors associated with early, late, and persistent clinically meaningful symptoms of depression in the first year after stroke .
0000000000200058Measures Associated With Early, Late, and Persistent Clinically Significant Symptoms of Depression 1 Year After Stroke in the AFFINITY Trial.
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Circulation: Statins for the prevention of cardiovascular disease, benefit more than 10 years!
Time of Update: 2022-04-21
Results showed that the policy, compared with ASSIGN 20, lowered the risk threshold for statin initiation to 10%, expanding eligibility from 804,000 (32% of adults ≥40 years of age without cardiovascular disease) to 1,445,500 (58 %) .
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"The Lancet Health and Longevity": Elderly people participating in choirs can significantly improve Alzheimer's and depression
Time of Update: 2022-04-21
COVID-19The primary endpoint obtained from 20 nursing home units (214 residents) demonstrated a beneficial effect of RCS (mean difference -4.
The primary endpoint obtained from 20 nursing home units (214 residents) demonstrated a beneficial effect of RCS (mean difference -4.
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JNNP: Tau-PET imaging predicts cognitive decline and progression of brain atrophy in patients with early Alzheimer's disease
Time of Update: 2022-04-21
In the present study, we aimed to explore whether regional tau binding measured at baseline is associated with the rate of AD progression after 2 years of follow-up, based on (a) cognitive decline in specific cognitive domains and (b) regional The progression of brain atrophy was assessed .
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American Journal of Psychiatry: Cognitive deficits and hippocampal atrophy in midlife in long-term marijuana users
Time of Update: 2022-04-21
published a research article in the American Journal of Psychiatry titled Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife to investigate whether there is greater cognition in middle-aged and older adults with a long history of smoking Defects and differences in brain structure .
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JNNP: Imaging of late window stroke after thrombectomy, results of a multicenter meta-analysis
Time of Update: 2022-04-21
statisticsDistribution of mRS at 90 days across the entire cohort and in the perfusion and collateral circulation cohortsOf the 608 patients, 379 (62.
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Lancet: Repeated intravenous cardiomyocyte-derived cell therapy in advanced Duchenne muscular dystrophy (HOPE-2): a multicenter, randomized, double-blind, placebo-controlled phase 2 trial
Time of Update: 2022-04-21
In the HOP Phase 1 clinical study, CAP-1002 showed an acceptable level of safety, with CAP-1002 appearing to preserve upper extremity and cardiac function after a one-time coronary infusion in 13 patients with Duchenne muscular dystrophy .
