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About one-fifth of this number is in the United States, where 1 million people with epilepsy are diagnosed with idiopathic generalized epilepsy (IGE)
.
About 10%–40% of these patients never achieve adequate epilepsy control with medication, and generalized tonic-clonic (GTC) seizures and myoclonic seizure types increase the risk of drug resistance, with significant adverse effects on quality of life
Diagnosing generalized tonic-clonic (GTC) seizures and myoclonic seizure types increases the risk of drug resistance with significant adverse effects on quality of life
A previous case report from the Administering FDA showed that a patient with IGE who received RNS in the CM area had significantly reduced seizure frequency and severity at 18 months
Subjects had drug-resistant epilepsy (a common diagnosis of IGE) and underwent thalamic RNS implantation as recommended by the Multidisciplinary Epilepsy Surgery Conference
.
Subjects were retrospectively studied through the Institutional Review Board (IRB)-approved Epilepsy Surgery Database, to which they agreed to be included
Subjects had drug-resistant epilepsy (a common diagnosis of IGE) and underwent thalamic RNS implantation as recommended by the Multidisciplinary Epilepsy Surgery Conference
Patient implant location and EEG recording
Patients experienced a reduction in seizure duration and severity (Engel 1B, IC, IIA, and IIIA) and a significant improvement in quality of life
.
Results are durable after at least 2 years of treatment
Patients experienced a reduction in seizure duration and severity (Engel 1B, IC, IIA, and IIIA) and a significant improvement in quality of life
Seizure Trends
The first IGE patients to undergo closed-loop thalamic stimulation were implanted and seizure outcomes were assessed over 2 years of treatment
.
By reducing seizure frequency and severity, CM-RNS produced a robust and durable treatment response in all patients in this cohort, resulting in a marked improvement in quality of life
The first IGE patients to undergo closed-loop thalamic stimulation were implanted and seizure outcomes were assessed over 2 years of treatment
SistersonND ,KokkinosV ,UrbanA SistersonNDSisterson KokkinosVKokkinos UrbanAUrban, et alResponsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: initial case seriesJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:25 February 2022 .
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