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Sci Transl Med︱GABAB receptor may rescue visual processing abnormalities in autism
Time of Update: 2022-03-08
The authors found that differences in the GABA pathway are responsible for abnormal visual processing in ASD patients, and high doses of GABAB receptor agonists abolish these differences, which has important implications for the development of personalized interventions based on sensory differences in ASD .
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Chinese Voice: How do inflammatory cytokines change in hyperacute stroke?
Time of Update: 2022-03-08
Main findings ➤Compared with healthy controls, the expression levels of plasma IL-1β, IL-2, IL-2R, IL-5, IL-10, CD40L, HGF, MIP-3α and MMP-1 in patients with AIS were significantly up-regulated , while IL-16 was down-regulated .
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Break through the restricted area!
Time of Update: 2022-03-08
On February 9, 2022, local time in the United States, at the International Stroke Congress in New Orleans, Japanese researchers announced the results of the RESCUE-Japan LIMIT trial, the first randomized controlled trial to demonstrate the efficacy of endovascular therapy for large core infarctions .
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[JAMA Sub-Journal] New research - "good" bacteria in the gut play a key role in brain health?
Time of Update: 2022-03-08
People with a better balance of bacteria in their gut are more likely to perform well on tests of standard thinking skills including concentration, flexibility, self-control and memory, new research shows .
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Gaze, visual field defect, see how international experts use NIHSS scores
Time of Update: 2022-03-08
Figure 6 NIHSS Gaze Score Middle cerebral artery lesions, which can also lead to visual field defects .
Figure 7 Visual field defect due to middle cerebral artery disease (adapted from speaker's PPT) Brainstem Lesion Stroke at the brainstem site can lead to cranial neuropathy .
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"Neurology": Clinical research on the gut-brain axis of the research team in Taiwan Province, Treasure Island, China!
Time of Update: 2022-03-08
201: A breakthrough in "Foreword to Immunology" by Yang Yuexin and others from China Disease Control and Prevention, a large clinical sample study found that oatmeal can improve blood lipids in patients with hypercholesterolemia through intestinal flora | Jun Weekly Issue 200: "Neurology" intestinal bacteria affect the brain!
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Science Wang Liping/Min Bin/Tang Shiming Reveal the Geometric Structure of Sequence Working Memory Representation in the Macaque Brain
Time of Update: 2022-03-08
The iNature human brain processes sequence information all the time, whether it is language communication, action implementation or episodic memory, all of which essentially involve the representatio
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Innovative technology vs intractable disease, leading gene editing is expected to prevent Alzheimer's disease doctor Maimeng broke the news
Time of Update: 2022-03-08
In the study, researchers such as Jonsson evaluated a large cohort of Icelandic population by whole-genome sequencing method and found that the A673T mutation can reduce the possibility of disease progression in Alzheimer's gene carriers, which is called "protective mutation" , and the strongest "protective mutation" ever discovered in humans .
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Neuron︱Gang Cao's research group reveals a new mechanism by which the nervous system senses pathogenic infection and fine-tunes immune response
Time of Update: 2022-03-08
On February 8, 2022, Professor Cao Gang's research group from Huazhong Agricultural University published an article "Neuron-derived neuropeptide Y fine-tunes the splenic immune responses" in Neuron, finding that the nervous system senses pathogenic infection, up-regulates neuropeptide NPY gene expression, and fine-tunes the splenic immune responses.
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Comprehensible machine learning model for multimodal data and its preliminary application in the study of neuronal cells in the brain
Time of Update: 2022-03-08
Paper information: Nam D Nguyen, Jiawei Huang, Daifeng Wang, A deep manifold-regularized learning model for improving phenotype prediction from multi-modal data, Nature Computational Science, 2, 38–46, 2022.
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"Developed limbs, simple mind" overturned!
Time of Update: 2022-03-08
The authors believe that selenoproteins produced during exercise are key to helping the brain grow new neurons, and humans may be able to use dietary selenium supplementation to reverse cognitive decline caused by aging and brain damage .
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Voice of China: What is the 5-year outcome of endovascular treatment for acute ischemic stroke with large vessel occlusion?
Time of Update: 2022-03-08
CONCLUSIONS: This study shows that patients with acute anterior circulation LVO who received EVT mostly had good outcomes after 5 years, but the mortality and stroke recurrence rates were also higher .
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What is the effect of intensive blood pressure control on stroke risk in patients with mild cognitive impairment?
Time of Update: 2022-03-08
Risk of the primary outcome was assessed by SPRINT randomization (intensive versus standard BP), and Cox models were adjusted for patient age, race, sex, baseline blood pressure, atrial fibrillation, diabetes, and smoking for the primary outcome .
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Voice of China: Balloon angioplasty combined with drug therapy vs drug therapy alone, who is better?
Time of Update: 2022-03-08
The primary objective of this study was to determine whether intracranial balloon angioplasty combined with aggressive medical therapy is superior to aggressive medical therapy alone for the prevention of ischemic stroke (≥70%) in patients with neurovascular stenosis.
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[Study] Pain makes people fat!
Time of Update: 2022-03-08
"This finding may shed light on the physiological mechanisms linking chronic pain to changes in eating behavior that may contribute to obesity , " said Paul Geha, PhD, lead author of the research paper .
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【ADV SCI】The world's first - artificial spinal cord implant is expected to restore the paralyzed to stand and walk!
Time of Update: 2022-03-08
For the first time, researchers at Tel Aviv University's Sagol Center for Regenerative Biotechnology have engineered 3D human spinal cord tissue and implanted it in a laboratory model of long-term chronic paralysis .
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New drug for migraine preventive treatment, the latest EU approval!
Time of Update: 2022-03-08
The incidence of adverse reactions of eptinezumab is extremely low, which may be related to the high selectivity and target specificity of eptinezumab itself; and as the first anti-migraine antibody drug administered by intravenous injection, eptinezumab can be in the blood Therapeutic levels are reached immediately, with efficacy on the day of infusion .
, Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2.
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J Neuroinflammation︱Jinfang Ge/Qingrong Xia's research group reveals part of the therapeutic mechanism of bone marrow mesenchymal stem cell exosomes on Alzheimer's disease
Time of Update: 2022-03-08
The results showed that injection of BMSC-exos into the lateral ventricle could reduce the protein and mRNA expression levels of inflammatory factors IL-1β, IL-6 and TNF-α in the hippocampus of AD mice (Fig.
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Is the patent foramen ovale a "time bomb" for stroke?
Time of Update: 2022-03-08
This article is from the NEJM Journal Watch Review of Refining Treatment Decisions for Patent Foramen Ovale Associated with Stroke by Seemant Chaturvedi, MD Patient Characteristics and Patent Foramen Ovale (PFO) The characteristics of the patients affect the likelihood of patients benefiting from PFO closure .
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Voice of China: Endovascular treatment for acute basilar artery occlusion, with or without alteplase, which is better?
Time of Update: 2022-03-08
This study aimed to compare the functional outcomes of EVT with and without intravenous thrombolysis (IVT) in patients with BAO-induced acute ischemic stroke (AIS) .
CONCLUSIONS: This study demonstrates that EVT prior to standard IVT is associated with better functional outcomes compared with direct EVT in BAO patients treated within 24 hours of onset .
