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Whether endovascular therapy (EVT) can improve outcomes in patients with acute basilar artery occlusion (BAO) remains controversial
.
This study aimed to compare the functional outcomes of EVT with and without intravenous thrombolysis (IVT) in patients with BAO-induced acute ischemic stroke (AIS)
.
The authors of the study are professors Nie Ximing and Liu Liping from Beijing Tiantan Hospital affiliated to Capital Medical University.
The results of the study will be presented in the form of oral abstracts at the 2022 International Stroke Congress (ISC 2022)
.
The author of this article: Yimaitong ISC report group compiled and organized by Yimaitong, please do not reprint without authorization
.
STUDY INTRODUCTION We enrolled patients with BAO-induced AIS who received EVT within 24 hours of onset in this multicenter cohort study to compare the efficacy and safety of IVT+EVT versus direct EVT
.
The primary outcome was functional independence at 90 days (modified Rankin Scale 0-2)
.
All outcomes were assessed using the adjusted odds ratio (aOR) of multivariate logistic regression
.
In addition, a meta-analysis of all recently published pivotal studies was performed and included studies of functional independence after EVT in BAO patients
.
Main findings: ➤ Of the 310 BAO patients enrolled, 241 (78%) received direct EVT and 69 (22%) received IVT+EVT
.
➤ Direct EVT was associated with poorer functional outcomes (aOR, 0.
46 [95% CI, 0.
25-0.
87]; P=0.
02)
.
IVT+EVT was associated with a lower proportion of patients requiring ≥3 stent retrievals (10.
14% vs 20.
75%)
.
➤Meta-analysis regression showed a potential positive association between IVT bridging first and functional independence (r, 0.
14 [95%CI: 0.
05-0.
24]; P<0.
01)
.
CONCLUSIONS: This study demonstrates that EVT prior to standard IVT is associated with better functional outcomes compared with direct EVT in BAO patients treated within 24 hours of onset
.
Yimaitong compiled from: Endovascular Treatment With Or Without Intravenous Alteplase For Acute Ischemic Stroke Due To Basilar Artery Occlusion.
ISC2022.
.
This study aimed to compare the functional outcomes of EVT with and without intravenous thrombolysis (IVT) in patients with BAO-induced acute ischemic stroke (AIS)
.
The authors of the study are professors Nie Ximing and Liu Liping from Beijing Tiantan Hospital affiliated to Capital Medical University.
The results of the study will be presented in the form of oral abstracts at the 2022 International Stroke Congress (ISC 2022)
.
The author of this article: Yimaitong ISC report group compiled and organized by Yimaitong, please do not reprint without authorization
.
STUDY INTRODUCTION We enrolled patients with BAO-induced AIS who received EVT within 24 hours of onset in this multicenter cohort study to compare the efficacy and safety of IVT+EVT versus direct EVT
.
The primary outcome was functional independence at 90 days (modified Rankin Scale 0-2)
.
All outcomes were assessed using the adjusted odds ratio (aOR) of multivariate logistic regression
.
In addition, a meta-analysis of all recently published pivotal studies was performed and included studies of functional independence after EVT in BAO patients
.
Main findings: ➤ Of the 310 BAO patients enrolled, 241 (78%) received direct EVT and 69 (22%) received IVT+EVT
.
➤ Direct EVT was associated with poorer functional outcomes (aOR, 0.
46 [95% CI, 0.
25-0.
87]; P=0.
02)
.
IVT+EVT was associated with a lower proportion of patients requiring ≥3 stent retrievals (10.
14% vs 20.
75%)
.
➤Meta-analysis regression showed a potential positive association between IVT bridging first and functional independence (r, 0.
14 [95%CI: 0.
05-0.
24]; P<0.
01)
.
CONCLUSIONS: This study demonstrates that EVT prior to standard IVT is associated with better functional outcomes compared with direct EVT in BAO patients treated within 24 hours of onset
.
Yimaitong compiled from: Endovascular Treatment With Or Without Intravenous Alteplase For Acute Ischemic Stroke Due To Basilar Artery Occlusion.
ISC2022.
