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Is the patent foramen ovale a "time bomb" for stroke?
Time of Update: 2022-03-08
This article is from the NEJM Journal Watch Review of Refining Treatment Decisions for Patent Foramen Ovale Associated with Stroke by Seemant Chaturvedi, MD Patient Characteristics and Patent Foramen Ovale (PFO) The characteristics of the patients affect the likelihood of patients benefiting from PFO closure .
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Voice of China: Balloon angioplasty combined with drug therapy vs drug therapy alone, who is better?
Time of Update: 2022-03-08
The primary objective of this study was to determine whether intracranial balloon angioplasty combined with aggressive medical therapy is superior to aggressive medical therapy alone for the prevention of ischemic stroke (≥70%) in patients with neurovascular stenosis.
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New drug for migraine preventive treatment, the latest EU approval!
Time of Update: 2022-03-08
The incidence of adverse reactions of eptinezumab is extremely low, which may be related to the high selectivity and target specificity of eptinezumab itself; and as the first anti-migraine antibody drug administered by intravenous injection, eptinezumab can be in the blood Therapeutic levels are reached immediately, with efficacy on the day of infusion .
, Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2.
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Express Delivers Positive Results from Pivotal Clinical Trial of Oral CGRP Receptor Antagonist for Migraine Patients in Asia Pacific
Time of Update: 2022-03-07
▎WuXi AppTec Content Team Editors On February 14, 2022, Biohaven Pharmaceutical and Pfizer announced positive top-line results from a Phase 3 clinical trial of rimegepant in adults with acute migraine .
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World Epilepsy Day: An article on the diagnosis and differential diagnosis of epilepsy
Time of Update: 2022-03-07
The absence of epileptiform discharges on EEG during seizures and the ineffectiveness of antiepileptic drug treatment are the keys to distinguish it from epilepsy.
The episodic psychiatric symptoms, transient loss of consciousness and limb twitches it causes should be differentiated from automatisms, absence seizures and generalized seizures of epilepsy, respectively .
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[Study] Behind the "good mutation": Gene variant can prevent Alzheimer's disease?
Time of Update: 2022-03-07
Recent studies have found that mutations in the brain's immune cells play an active role in protecting people against Alzheimer's disease .
"The PLCG2 P522R mutation is known to increase Alzheimer's disease risk variant TREM2 downstream signaling, so it would be very interesting to investigate the effect of TREM2-stimulating antibodies on microglia-T cell crosstalk," Davtyan said.
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Complex and diverse?
Time of Update: 2022-03-07
Diagnosis Basis ➤ Middle-aged and elderly people with risk factors for cerebrovascular disease, mostly male; ➤ Acute onset and rapid progression, with ischemic lesions in two or more parts of the brainstem, diencephalon and posterior cerebral artery innervation Symptoms and signs; ➤Clinical manifestations include varying degrees of disturbance of consciousness, eye movement disorders and pupil abnormalities, with motor and sensory abnormalities, hemianopia or cortical blindness, behavioral abnormalities and memory impairment, etc.
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New way to prevent dementia?
Time of Update: 2022-03-07
To explore the relationship between obesity and cognitive function, the researchers performed bioelectrical impedance analysis on 9,166 participants to measure their body fat percentage and 6,773 people with magnetic resonance imaging to assess their vascular brain damage, and their visceral fat volume was measured; participants' cognitive function was assessed using the Digital Sign Substitution Test (DSST) and Montreal Cognitive Assessment (MoCA) scale; and cardiovascular risk was assessed using the INTERHEART Risk Score .
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Food induces sexual desire: Chinese scientists "Nature" published an article to reveal the aphrodisiac effect of protein
Time of Update: 2022-03-07
▲The transition from eating to mating requires Dh31 and Dh31 receptors in the gut (image source: Reference [1]) and after entering the brain, Dh31 can activate two types of neurons that express Dh31 receptors, and then through two Separate neural pathways influence Drosophila behavior: One type of neurons inhibits feeding; another promotes courtship .
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Dajia Online: How to manage blood pressure in patients with cerebral hemorrhage
Time of Update: 2022-03-07
For example, the "Expert Consensus on Diagnosis and Treatment of Emergency Hypertension in China" [7] pointed out that for patients with spontaneous cerebral hemorrhage with a systolic blood pressure of 150-220 mmHg and no contraindications to acute antihypertensive treatment, it is safe to reduce the systolic blood pressure to 140 mmHg in the acute phase .
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Is thrombectomy beneficial for extra-window anterior circulation stroke?
Time of Update: 2022-03-07
STUDY INTRODUCTION We conducted a systematic review and meta-analysis of individual case data of randomized controlled trials of endovascular treatment of acute ischemic stroke with onset over 6 hours between January 1, 2010, and March 1, 2021 .
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Cerebral amyloid angiopathy may increase the risk of recurrent cerebral hemorrhage?
Time of Update: 2022-03-07
Studies have shown that patients with cerebral amyloid angiopathy (CAA) are at increased risk of recurrent intracerebral hemorrhage (ICH) .
Survival analyses were performed to assess the incidence of recurrent intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and acute ischemic stroke (AIS) in the propensity-matched group .
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Eating more of these foods can greatly reduce the risk of death from Parkinson's disease
Time of Update: 2022-03-07
Table: Apple intake is associated with reduced risk of PD in men Not just a 2012 study, but a study published last year in Neurology showed that eating at least half a serving of flavonoids such as strawberries, oranges, peppers, and apples per day People who are high in food may have a reduced risk of cognitive decline by up to 20% .
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PNAS: Zhao Bingqiao's team from Fudan University revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke
Time of Update: 2022-03-07
Bingqiao Zhao from the Institute of Brain Science of Fudan University/State Key Laboratory of Medical Neurobiology published a research paper titled "The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice" online in the Proceedings of the National Academy of Sciences "PNAS".
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How does the brain do arithmetic?
Time of Update: 2022-03-07
In simple terms, this experiment involves implanting tiny electrodes in the MTL (hippocampus and its cortex) region of the brain, allowing volunteers to add and subtract to test their neuronal activity .
These neurons selectively increase firing after a computational command (ie, add or subtract) .
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Chinese scientists "Science" published an article to reveal the encoding mechanism of brain sequence memory
Time of Update: 2022-03-07
In a new study published in "Science", Tang Shiming's group from Peking University School of Life Sciences and Wang Liping's group from the Center for Excellence in Brain Science and Intelligent Technology (Institute of Neuroscience), Chinese Academy of Sciences, Shanghai Brain Science and Brain-like Research Center Researcher Min Bin collaborated to uncover the coding mechanism of neurons storing sequence memory in rhesus monkeys .
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Cereb Cortex︱Cui Fang/Liu Jie/Gu Ruolei's research group collaborated to reveal the neural mechanism of resource scarcity inhibiting prosocial behavior
Time of Update: 2022-03-07
Liu Jie from the School of Psychology, Shenzhen University, and researcher Gu Ruolei from the University of Chinese Academy of Sciences published a paper entitled "How The paper resource sharing resists scarcity: the role of cognitive empathy and its neurobiological mechanisms" explores this issue, elaborating on the neural mechanisms underlying the reduction in prosocial sharing behavior and its relationship to empathy in resource-poor settings .
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Cell first, Nature later: After 9 years, the experts in the field of gut microbiota have solved the anxiety mystery of the brain-gut axis!
Time of Update: 2022-03-07
Animal experiments have shown that the gut microbiota modulates the brain's production of neurotransmitters such as dopamine, norepinephrine, serotonin, and gamma-aminobutyric acid, which in turn affects brain development and myelination, as well as social, emotional, and anxiety-like behaviors .
4EP-positive mice treated with clemastine fumarate ameliorated anxiety-like behavioral disorders while promoting oligodendrocyte maturation .
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How to manage aphasia after stroke, see the latest Chinese expert consensus
Time of Update: 2022-03-07
Clinical management process ➤ PSA screening by a neurologist or neurosurgeon within 24 hours of stroke onset; after the condition is stable, a speech therapist will conduct a systematic rehabilitation assessment for PSA patients .
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Nat Genet's new discovery of the brain-gut axis, Dr. Qin Youwen and other large cohort multi-omics reveal the potential pathogenic bacteria of depression
Time of Update: 2022-03-07
On February 3, 2022, Guillaume Méric of Baker Heart and Diabetes Institute, Australia, in collaboration with Michael Inouye (first author is Qin Youwen) published the article Combined effects of host genetics and diet on human gut microbiota and incident disease in a Nature Genetics single population cohort, revealing that specific gut bacteria are potential causative factors of depression [1] .
