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Courier's potential "first-in-class" DMD new drug Phase 2b clinical trial results published!
Time of Update: 2022-09-06
▲If you have any business needs, please long press to scan the QR code above, or▎Edited by WuXi AppTec Content TeamToday, Santhera Pharmaceuticals and ReveraGen BioPharma jointly announced the positive results of the VISION-DMD clinical 2b trial of Duchenne muscular dystrophy (DMD) investigational drug vamorolone, published in the leading journal JAMA Neurology .
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Infantile epilepsy accompanied by wandering focal seizures: clinical features, etiology, and treatment
Time of Update: 2022-09-06
[35] reported two sibling children with early-onset myoclonic encephalopathy whose parents were related by blood, and one child was detected carrying the SLC25A22 gene homozygous mutation c.
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The brain will accumulate toxins in 6 hours. These habits make the brain young!
Time of Update: 2022-09-06
. _ When the brain continues to perform high-intensity cognitive work, the potentially "harmful substance" glutamate accumulates in the brain's prefrontal cortex, affecting decision-making .
. _ When the brain continues to perform high-intensity cognitive work, the potentially "harmful substance" glutamate accumulates in the brain's prefrontal cortex, affecting decision-making .
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Molecular Psychiatry: Alcohol damages telomeres
Time of Update: 2022-09-06
Top-level multivariate-adjusted observational estimates (in 245,354 UKB participants) and 2-sample Mendelian randomization estimates (2-sample design) were used for genetically predicted alcohol consumption and the association between drinking disorders and telomere length .
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Cell Rep: Early Alzheimer's disease may have neural circuit dysfunction during sleep
Time of Update: 2022-09-06
The team led by Professor Inna Slutsky conducted a series of studies on this problem and found that in AD model mice in a awake state before cognitive impairment symptoms appeared, the hippocampal neural circuit was not damaged, but during non-REM sleep (NREM) and under general anesthesia (decreased neuronal activity), dysfunction of neural circuit homeostasis in the hippocampus .
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Movement disorders: Xiangya Hospital: Can a dog sniff Parkinson's disease?
Time of Update: 2022-09-06
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
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Nature sub-journal: Anti-aging vaccine coming?
Time of Update: 2022-09-06
Recently, a research team from Juntendo University in Japan published a research paper entitled: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice in the journal Nature Aging [2] .
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HUMAN BRAIN MAPPING: Alzheimer's disease neuropsychiatric symptoms associated with multimodal brain networks
Time of Update: 2022-09-06
, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, focusing on four goals: (1) to identify multimodal brain patterns associated with NPS total score in AD;(2) Assess between-group differences in these identified regions;(3) Evaluate the predictive ability of identified brain patterns to cognitive changes;(4) Identify common and unique multimodal attributes of the four neuropsychiatric sub-syndromes (psychotic, affective symptoms, hyperactivity, apathy) .
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Neurology: What do you know about gait disturbances in Parkinson's disease patients and compensation strategies?
Time of Update: 2022-09-06
from the University of Nijmegen, The Netherlands, assessed the efficacy of five different compensatory strategies: external cues, internal cues, movement observation, motor imagery, and adoption of new walking patterns .
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Hypertension: Association of blood pressure fluctuations during hospitalization for ischemic stroke with 3-month clinical outcomes
Time of Update: 2022-09-06
CONCLUSIONS: Larger blood pressure fluctuations during hospitalization were associated with an increased risk of adverse outcomes 3 months after the onset of ischemic stroke, independent of mean blood pressure .
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Neurology: E-type apolipoprotein and markers of cerebrovascular disease in patients with cerebral hemorrhage
Time of Update: 2022-09-06
0000000000200851 A study published in Neurology investigated the relationship between neuroimaging markers of apolipoprotein E-type (APOE), intracerebral hemorrhage (ICH), and cerebral amyloid angiopathy (CAA) .
0000000000200851 A study published in Neurology investigated the relationship between neuroimaging markers of apolipoprotein E-type (APOE), intracerebral hemorrhage (ICH), and cerebral amyloid angiopathy (CAA) .
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Movement disorders: PM2.5 may induce Parkinson's disease
Time of Update: 2022-09-06
Air pollution exposure also induces α-Syn pathology within the OB of children and relatively young adults .
Air pollution exposure also induces α-Syn pathology within the OB of children and relatively young adults .
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Movement disorders: Gender frequency differences in glucosidase variant carriers and familial Parkinson's disease
Time of Update: 2022-09-06
They assessed differences in sex-specific frequencies of GBA PD, including a subset of GBA variant severity, LRRK2 PD, and PD in the Ashkenazi Jewish cohort of idiopathic PD .
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European Radiology: 3T MR neuroimaging of the lumbosacral plexus with ATTRv-PN
Time of Update: 2022-09-06
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
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JAMA Neuro: Different temporal trends in stroke incidence in young versus older adults
Time of Update: 2022-09-06
references:Diverging Temporal Trends in Stroke Incidence in Younger vs Older People, A Systematic Review and Meta-analysis Overall stroke incidence in high-income countries is declining, but data on temporal trends in the incidence of young stroke (ie, stroke in individuals under 55 years of age) are conflicting .
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Front. Cell Dev: Bidirectional cycling between lysosomes and α-syn (top)
Time of Update: 2022-09-06
Compilation Author: Level 10 Fatty (Brainnews creative team) Reviewer: Simon (Brainnews Editorial Office) Lysosomal dysfunction exists in the brains of patients with Parkinson's disease, while the accumulation and aggregation of α-syn is the main pathogenesis of PD .
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Neurology: Association of the rate of aging as measured by blood DNA methylation with age-related cognitive impairment and dementia
Time of Update: 2022-09-06
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia [published online ahead of print, 2022 Jul 6].
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia [published online ahead of print, 2022 Jul 6].
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European Radiology: The value of DTI in the differential diagnosis of neuromyelitis optica spectrum disorders and multiple sclerosis
Time of Update: 2022-09-06
1007/s00330-022-08779-3 Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are two major inflammatory demyelinating diseases of the central nervous system, with similar clinical symptoms and imaging findings, but widely differing treatment modalities .
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Alzheimer Dementia: Effects of intensive blood pressure reduction on plasma Aβ, neurofilament light chain and total tau in dementia in the SPRINT trial
Time of Update: 2022-09-06
references:Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT) It has become a consensus that lowering blood pressure can reduce the risk of cardiovascular disease, but whether lower blood pressure is better, and what should be the ideal blood pressure lowering target?
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Cell Post-translational modification profiles of human pathological tau proteins distinguish clinical stages of Alzheimer's disease
Time of Update: 2022-09-06
Proposed model of Tau fibrosis formation based on stoichiometric PTM analysisCollectively, this study provides an unprecedented quantitative and qualitative view of the molecular characterization of pathological Tau subtypes in human disease, which is critical for rational design of antibody and small molecule therapeutics and early clinical diagnosis .
