HUMAN BRAIN MAPPING: Alzheimer's disease neuropsychiatric symptoms associated with multimodal brain networks

Neuropsychiatric symptoms (NPS) are frequently observed in mild cognitive impairment (MCI) and Alzheimer's disease (AD), involving 80% of AD patients

Concomitant neuropsychiatric symptoms are associated with accelerated progression of Alzheimer's disease (AD)

Recently, HUMAN BRAIN MAPPING published a research article by Kaicheng Li et al.

(2) Assess between-group differences in these identified regions;

(3) Evaluate the predictive ability of identified brain patterns to cognitive changes;

(4) Identify common and unique multimodal attributes of the four neuropsychiatric sub-syndromes (psychotic, affective symptoms, hyperactivity, apathy)

On the basis of AD continuum, with NPS total score as reference, a supervised learning strategy was used to guide four-way multimodal neuroimaging fusion (Amyloid, Tau, gray matter volume, brain function)

Flowchart of NPS-guided multimodal fusion and predictive analysis

The result is as follows:

The determined joint components were referred to the total NPS score

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Correlations between imaging feature load and cognitive scores in all subjects

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Determining the combined components using the NPS sub-syndromic score as a reference

Multimodal brain regions associated with neuropsychiatric symptoms (NPS) and their predictiveness in cognitive progression

In conclusion, NPS is associated with multimodal imaging patterns involving complex neuropathology and can effectively predict longitudinal cognitive decline

Original source:

Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease

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