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Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting more than 4 million people worldwide
Figure 1: Paper cover image
Interestingly, the spatial progression of α-Syn pathology follows a stereotyped pattern in PD brains
Several epidemiological studies have found that exposure to air pollution is highly correlated with the onset and progression of PD
Shockingly, chronic exposure to high levels of air pollution led to the accumulation of α-Syn in the human brain and increased levels of oligomeric α-Syn in the cerebrospinal fluid
In addition, children living in polluted areas of Mexico City were at increased risk of developing anosmia, one of the early symptoms of PD
In this way, Xin Yuan et al.
Figure 2: The results of the paper
They found that PM2.
In transgenic mice expressing the human A53T mutant α-Syn (α-Syn A53T mice), intracerebral injection or intranasal infusion of PM2.
These results suggest that PM2.
