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JAMA sub-journal: Alzheimer's disease progression and longitudinal cognitive changes in patients with childhood genetic disease "Down syndrome"
Time of Update: 2022-08-15
This study found a high-risk association between the development of symptomatic AD and progressive cognitive decline in patients with DS, informing clinical trials for AD prevention in adults with DS .
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How to choose the treatment drugs for migraine in the acute phase?
Time of Update: 2022-08-15
▌ Commonly used criteria for the efficacy of acute treatment of migraine: ① Painless after 2 hours; ② Pain improved after 2 hours, from moderate to severe pain to mild or no pain (or VAS decreased by more than 50%); ③ The effect is repeatable, 3 times 2 or more attacks were effective; ④ There was no recurrence of headache within 24 hours after successful treatment or no need to take medicine again .
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After 3 years, NICE updated guidelines: diagnosis and initial management of stroke and transient ischemic attack in people over 16 years of age World Stroke Prevention Day
Time of Update: 2022-08-15
In April 2022, the UK National Institute for Health and Clinical Excellence (NICE) updated guidelines for the diagnosis and initial management of stroke and transient ischemic attack in people over 1
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Light illuminates the "source of imagination": the secret of neuron visualization
Time of Update: 2022-08-15
. After more than ten years of research and development and optimization, fMOST technology has the advantages of high resolution, high throughput, and high definition, and automatic imaging can quickly, efficiently and accurately obtain neuronal morphological information, which can be used for subsequent reconstruction and analysis of neurons in the whole brain.
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Brain watershed infarction classification knowledge card
Time of Update: 2022-08-15
Yimaitong Introduction In 2019, the editor launched the "Knowledge Card" column, which organizes some clinical disease-related knowledge points in a simple and easy-to-save form, so that clinicians can use fragmented time to review the past and learn, which is very popular among doctor readers.
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Science: Cortical inhibitory microcircuits maintain memory consolidation in REM sleep
Time of Update: 2022-08-15
Two-photon in vivo calcium imaging revealed decreased soma activity in dorsal prefrontal cortex (dPFC) pyramidal neurons during REM, whereas However, the apical dendritic activity was increased, indicating the existence of sleep-related neuronal cell body activity and dendritic activity decoupling changes .
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Do you know the diagnosis and treatment of clinically isolated syndrome?
Time of Update: 2022-08-15
Clinically isolated syndrome (CIS) refers to the first occurrence of an inflammatory demyelinating event in the central nervous system (CNS), with related symptoms and objective signs lasting at leas
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Science︱Reversible CD8 T cell-neuron interaction: an important mechanism by which aging inhibits nerve regeneration
Time of Update: 2022-08-15
CD8 T cell-neuron cross-talk: a hallmark of axonal regenerative decline Author︱Luming Zhou and Simone Di Giovanni (Department of Brain Sciences, Imperial College London, Division of Neuroscience, London, United Kingdom) Editor-in-Chief︱Sizhen WangAssociate Editor︱Yi LuEditor︱Jiaxue Zha Aging has been linked to an increased prevalence of axonal injuries, which are characterized by inadequate regeneration and significant impairment [1-4].
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Neurology: How A-beta and Vascular Risk Factors Affect Brain Atrophy?
Time of Update: 2022-08-15
vascular hypertension cholesterol diabetesFigure 1: Paper cover imageFigure 1: Paper cover imageStudies have identified vascular risk and Aβ deposition as independent predictors of brain atrophy, suggesting that these two processes are associated with overlapping and distinct patterns of brain atrophy quantified by magnetic resonance imaging (MRI) .
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The most beautiful leading readers-the editor-in-chief interprets the "Guidelines for the Prevention and Treatment of Senile Dementia in China"
Time of Update: 2022-08-15
Rehabilitation of dementia mainly includes a series of comprehensive rehabilitation methods and intervention measures for the core symptoms of dementia such as cognition, behavior and social function state, following the principle of "tailor-made", to improve the patient's cognitive and living ability as much as possible, and improve the quality of life and self-efficacy to maintain their independence in life .
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15-year-old girl suddenly blurred vision, what is the reason?
Time of Update: 2022-08-15
AQP4-IgG negative or NMOSD diagnostic criteria of unknown AQP4-IgG status (1) In 1 or more clinical episodes, at least 2 core clinical features and all of the following conditions are met: ① At least 1 core clinical feature is optic neuritis, acute long segment Transverse myelitis or medullary zone retal syndrome .
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Cell sub-journal: Social isolation affects brain gene expression, disrupts brain development
Time of Update: 2022-08-15
Recently, Sarah Kocher's team at Princeton University (first author Wang Yan, now an assistant professor at the University of Washington) published a research paper entitled: Isolation disrupts social interactions and destabilizes brain development in bumblebees in Current Biology, a sub-journal of Cell .
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Neurobiol Dis︱Jin Yu's group reveals the neuroprotective role of microglia GPR55 in anxiety-depression-like behaviors
Time of Update: 2022-08-15
, Neurobiol Dis. 2022) Conclusion and discussion, inspiration and prospect This study shows that the decreased expression of hippocampal G protein-coupled receptor 55 (GPR55) is associated with chronic social frustration stress (CSDS) Activation of GPR55 reversed the detrimental effects of CSDS in relation to the social avoidance deficits induced .
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How to diagnose and treat refractory epilepsy with "negative" imaging?
Time of Update: 2022-08-15
From the perspective of seizure symptoms, the onset of protrusions, vocalization, shouting, twitching of one side of the face and limbs, and rapid spread of discharges quickly lead to generalized seizures, which are more in line with focal seizures from the frontal lobe .
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PNAS︱Feng Guoping's lab reveals the important role of frontal thalamic circuits in working memory
Time of Update: 2022-08-15
Written by ︱ Ying Zhang editor in charge ︱ Plate made by Wang Sizhen ︱ Jiaxue Zha The global population is entering an aging stage, and the number and proportion of the elderly population in almost e
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Biol Psychiatry︱ Tianming Gao's team reveals the regulation of astrocytes on adult hippocampal neurogenesis and memory through acetylcholine receptor M1
Time of Update: 2022-08-15
, Biol Psychiatry, 2022) Conclusion and discussion, inspiration and prospect Transgenic mice specifically knocked out muscarinic acetylcholine receptor M1 (Chrm1) on glial cells, combined with immunofluorescence staining, retroviral labeling, primary astrocyte culture, electrophysiology, western blotting, and behavior From the molecular, cellular and overall levels, it has been revealed that astrocytes sense cholinergic signals mediated by Chrm1, thereby regulating the neurogenesis of the adult hippocampus, and the mechanism may be through the release of BDNF ( Figure 8) .
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Curr Biol︱Chen Nannan et al reveal that translation of synaptic region causes asymmetric distribution of CaMKII protein and its role in memory formation
Time of Update: 2022-08-15
Written by ︱Chen Nannan ︱Wang Sizhen, Lu Yizhiban ︱Zha Jiaxue Synapses are the connections between neurons in the nervous system and the basis for the formation of behavioral plasticity . There are a
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What are the differences between the Japanese guidelines for mechanical thrombectomy and those in my country?
Time of Update: 2022-08-15
. 1) For early acute ischemic stroke, in addition to drug therapy including intravenous infusion of rt-PA (alteplase), it is recommended that patients who meet all of the following conditions use a stent extractor or suction within 6 hours of onset.
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Front Aging Neurosci︱PTAFR as a Novel Biomarker for Alzheimer's Diagnosis and Treatment
Time of Update: 2022-08-15
Written by Liu Junxiu, edited by Liu Mingyan, plate made by Wang Sizhen, Zha Jiaxue Alzheimer's Disease (AD), as an age-related neurodegenerative disease, seriously endangers the life of the elderly[
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Lp(a) Master Class No. 12｜Professor Liu Liping: The causal relationship between Lp(a) and stroke
Time of Update: 2022-08-15
In the last issue of the Lp(a) Masterclass Microclass, we detailed the latest evidence on Lp(a) and cardiovascular disease (CVD) and Lp(a) research areas such as Lp(a) and CVD management latest devel
