-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Written by ︱Chen Nannan ︱Wang Sizhen, Lu Yizhiban ︱Zha Jiaxue Synapses are the connections between neurons in the nervous system and the basis for the formation of behavioral plastici.
There are a large number of proteins in the synaptic region, among which the phosphorylated protein Ca2+/CaMKII (calmodulin-dependent protein kinase II) accounts for about 2% of the total protein in the central nervous system [1], and plays a key role in the formation of behavioral plastici.
role [2-
Studies have shown that the 3'-UTR (three prime untranslated region) of both mammalian CaMKII2A and Drosophila CaMKII contains key regulators of neuronal activity-dependent synaptic plasticity that can occur postsynaptic [5,6] and presynaptic terminal [7,
However, the mechanism of formation of superabundant CaMKII enrichment in synaptic regions and its role in the nervous system is a completely unexplored top.
On May 10, 2022, the team of Leslie.
Griffith and Nannan Chen of the Department of Biology, Brandeis University, USA published a paper entitled "Local translation provides the asymmetric distribution of CaMKII required for associative memory in Current Biolo.
Formation" article, elucidating the mechanism of asymmetric distribution of CaMKII in neurons and its key role in synaptic plasticity and memory formati.
The authors used CRISPR/Cas9 technology to insert green fluorescent protein GFP in situ into the CaMKII gene, and found that in the Drosophila brain, CaMKII protein was actively enriched in the synaptic region of neurons, while the content in the soma region of neurons was very l.
The authors segmented the 3'UTR region of CaMKII according to the degree of conservation across species; and found that the highly conserved distal region in the 3'UTR is a homeopathic regulator of CaMKII synaptic enrichme.
Interestingly, there was no difference in the total amount of RNA and RNA content in the synaptic region in the Drosophila brain, suggesting that this homeopathic regulator specifically regulates translation in the synaptic region, rather than RNA transport (F.
Figure 1 The distal region of the 3'UTR of CaMKII is a cis-acting factor that enhances translation in the axonal region (Source: N Chen, et .
, Curr Biol, 202
By screening for RNA-binding proteins in this recognition region, the authors It was found that the RNA-binding protein Mub, which is specifically expressed in the mushroom body of the Drosophila brain memory center, can specifically recognize and bind to a 23-base recognition region in the homeopathic regulat.
Downregulation of Mub or knockdown of this recognition region can significantly reduce the expression of CaMKII prote.
Further, the authors used CRISPR/Cas9 technology to knock out the recognition region in situ and mushroom body region-specifically, and found that the synaptic expression of CaMKII protein was significantly reduced, the synaptic plasticity of neurons was destroyed, and the level of associative learning and memory was also reduc.
significantly reduced (Figure
These findings suggest that RNA-binding proteins regulate the regional translation of synaptic proteins in the synaptic region, and this regional translation plays a key role in the formation of neuroplastici.
Figure 2 Deletion of Mub recognition regions impairs neuronal plasticity and memory (Source: N Chen, et .
, Curr Biol, 2022) Figure 3 Summary of work: translation of synaptic regions causes asymmetric distribution of CaMKII protein, and its The role in memory formation (Image source: N Chen, et .
, Curr Biol, 2022) Conclusion and discussion, inspiration and prospect In summary, the author constructed a series of in situ CaMKII gene through CRISPR/Cas9 technology In a transgenic Drosophila line, a 23-base synaptic region located on the 3'UTR was found to have a homeopathic factor with enhanced translation, and the RNA-binding protein Mub was found to bind this factor and enhance translation (F.
This translational regulation in synaptic regions is the basis for the enrichment of CaMKII synaptic regions, and also plays a crucial role in the formation of neural plasticity and associative learning and memory (F.
Synaptic translation is an efficient and specific translation mechanism, and many RNA-binding proteins can play various roles in this process, such as translation enhancement/translation inhibition/RNA degradati.
Disturbances in the function of RNA-binding proteins can contribute to the development of neurological diseas.
At the same time, due to the low content of RNA in the synaptic region and the low signal-to-noise ratio of imaging, its identification has always been a difficult problem to overco.
In the future, with the development and maturity of more technologies, it is hoped that the regulatory mechanism of RNA in the synaptic region will be further studi.
In conclusion, this study found that the RNA-binding protein Mub enhances the translation of CaMKII in the synaptic region, which is necessary for the formation of associative learning and memory (F.
Original link: https://autho.
elsevi.
com/c/1f2ob3QW8R~cbw This article was supported by NIH R37 NS112810 (Leslie.
Griffith) and NIH R01 DA043195 (Leslie.
Griffith) fun.
The first author is Chen Nannan (the second from the left in the upper row), and the corresponding author Leslie.
Griffith (the first from the left in the upper ro.
He received his .
from the Institute of Biophysics, Chinese Academy of Scienc.
After graduation, he did post-doctoral research in the Griffith Laboratory of Brandeis Universi.
About the Communications Lab: The Griffith Lab (https:// at Brandeis University in suburban Boston is dedicated to studying the biochemical and cellular basis of behavi.
The laboratory is currently recruiting postdoctoral fellows, and applications from aspirants are welco.
Talent recruitment[1] "Logical Neuroscience" is looking for an associate editor/editor/operation position (online office) Selected articles from previous issues[1] Review of Front Aging Neurosci︱Fan Dongsheng's team focuses on peripheral and central immunity in amyotrophic lateral sclerosis Interaction of systems 【2】NPP︱Wei Lu’s team revealed a new mechanism of phosphorylation of auxiliary subunits of GABAA receptors to regulate neural behavior 【3】Cereb Cortex︱Pattern rigidity, temporal dynamics of ventromedial prefrontal cortex affect rumination and depression The role of [4] Front Aging Neurosci︱PTAFR as a novel biomarker to assist in the diagnosis and treatment of Alzheimer's disease [5] PNAS︱ Feng Guoping's laboratory reveals the important role of front thalamic circuits in working memory [6] Mol Psychiatry︱ Keqiang Ye’s group reveals that inflammation-activated C/EBPβ/AEP signaling pathway mediates high-fat diet-induced diabetes and Alzheimer’s disease 【7】PNAS︱ Changhe Wang’s group reveals synaptic exocytosis-endocytosis balance New Mechanism【8】Autophagy︱Ye Yihong’s research group revealed a new molecular mechanism of neuronal ceroid lipofuscin deposition: DNAJC5/CSPα gene mutation leads to lysosomal homeostasis imbalance【9】J Neuroinflammation | New evidence on the relationship of cerebral small vessel disease [10] Science︱Neural mechanism of non-cued goal-directed behavior High-quality scientific research training course recommendation [1] Academic paper writing practical training course (Live: 20221~22) [2] Single cell Symposium on Sequencing and Spatial Transcriptomics Data Analysis (Tencent Online Conference on June 11-12) [3] Symposium on Patch Clamp and Optogenetics and Calcium Imaging Technologies May 21-22 Tencent Conference Academic Symposium [1] Symposium Series︱Inside the Brain: Imaging Research References for Amygdala Circuits (swipe up and down to read) 1, Erondu, NE, and Kennedy, MB (198
Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat bra.
.
Neuros.
5, 3270–327 https://d.
org/11523/jneuros.
05-12-03271982, Griffith, LC, Verselis, LM, Aitken, KM, Kyriacou, CP, Danho,.
, and Greenspan, RJ (199
Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plastici.
Neuron 10, 501–50 https://d.
org/11016/0896-6273(93)90337.
3, Silva, AJ, Paylor,.
, Wehner, JM, and Tonegawa,.
( 199
Impaired spatial learning in a-calcium-calodulin kinase II mutant mi.
Science 257, 206–21 https://d.
org/11126/scien.
1321494, Bayer, KU, and Schulman,.
(2019.
CaM kinase: still inspiring at 4 Neuron 103, 380–39 https://d.
org/11016.
neur.
2010035, Aakalu,.
, Smith, WB, Nguyen,.
, Jiang,.
, and Schuman, EM (200
Dynamic visualization of local protein synthesis in hippocampal neuro.
Neuron 30, 489–50 https://d.
org/11016/s0896-6273(01)00295-6,Miller,.
, Yasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaste.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleYasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https ://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleYasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https ://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleJones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/ s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neurosc.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https:/ /d.
org/11523/JNEUROS.
1313-1201 End of this articleJones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/ s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neurosc.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https:/ /d.
org/11523/JNEUROS.
1313-1201 End of this article(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org /11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (2017.
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 This paper Finish(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org /11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (2017.
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 This paper FinishDisruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016/.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3 'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paperDisruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016/.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3 'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper1016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Cel.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https ://d.
org/11523/JNEUROS.
1313-1201 End of article1016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Cel.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https ://d.
org/11523/JNEUROS.
1313-1201 End of article, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper
There are a large number of proteins in the synaptic region, among which the phosphorylated protein Ca2+/CaMKII (calmodulin-dependent protein kinase II) accounts for about 2% of the total protein in the central nervous system [1], and plays a key role in the formation of behavioral plastici.
role [2-
Studies have shown that the 3'-UTR (three prime untranslated region) of both mammalian CaMKII2A and Drosophila CaMKII contains key regulators of neuronal activity-dependent synaptic plasticity that can occur postsynaptic [5,6] and presynaptic terminal [7,
However, the mechanism of formation of superabundant CaMKII enrichment in synaptic regions and its role in the nervous system is a completely unexplored top.
On May 10, 2022, the team of Leslie.
Griffith and Nannan Chen of the Department of Biology, Brandeis University, USA published a paper entitled "Local translation provides the asymmetric distribution of CaMKII required for associative memory in Current Biolo.
Formation" article, elucidating the mechanism of asymmetric distribution of CaMKII in neurons and its key role in synaptic plasticity and memory formati.
The authors used CRISPR/Cas9 technology to insert green fluorescent protein GFP in situ into the CaMKII gene, and found that in the Drosophila brain, CaMKII protein was actively enriched in the synaptic region of neurons, while the content in the soma region of neurons was very l.
The authors segmented the 3'UTR region of CaMKII according to the degree of conservation across species; and found that the highly conserved distal region in the 3'UTR is a homeopathic regulator of CaMKII synaptic enrichme.
Interestingly, there was no difference in the total amount of RNA and RNA content in the synaptic region in the Drosophila brain, suggesting that this homeopathic regulator specifically regulates translation in the synaptic region, rather than RNA transport (F.
Figure 1 The distal region of the 3'UTR of CaMKII is a cis-acting factor that enhances translation in the axonal region (Source: N Chen, et .
, Curr Biol, 202
By screening for RNA-binding proteins in this recognition region, the authors It was found that the RNA-binding protein Mub, which is specifically expressed in the mushroom body of the Drosophila brain memory center, can specifically recognize and bind to a 23-base recognition region in the homeopathic regulat.
Downregulation of Mub or knockdown of this recognition region can significantly reduce the expression of CaMKII prote.
Further, the authors used CRISPR/Cas9 technology to knock out the recognition region in situ and mushroom body region-specifically, and found that the synaptic expression of CaMKII protein was significantly reduced, the synaptic plasticity of neurons was destroyed, and the level of associative learning and memory was also reduc.
significantly reduced (Figure
These findings suggest that RNA-binding proteins regulate the regional translation of synaptic proteins in the synaptic region, and this regional translation plays a key role in the formation of neuroplastici.
Figure 2 Deletion of Mub recognition regions impairs neuronal plasticity and memory (Source: N Chen, et .
, Curr Biol, 2022) Figure 3 Summary of work: translation of synaptic regions causes asymmetric distribution of CaMKII protein, and its The role in memory formation (Image source: N Chen, et .
, Curr Biol, 2022) Conclusion and discussion, inspiration and prospect In summary, the author constructed a series of in situ CaMKII gene through CRISPR/Cas9 technology In a transgenic Drosophila line, a 23-base synaptic region located on the 3'UTR was found to have a homeopathic factor with enhanced translation, and the RNA-binding protein Mub was found to bind this factor and enhance translation (F.
This translational regulation in synaptic regions is the basis for the enrichment of CaMKII synaptic regions, and also plays a crucial role in the formation of neural plasticity and associative learning and memory (F.
Synaptic translation is an efficient and specific translation mechanism, and many RNA-binding proteins can play various roles in this process, such as translation enhancement/translation inhibition/RNA degradati.
Disturbances in the function of RNA-binding proteins can contribute to the development of neurological diseas.
At the same time, due to the low content of RNA in the synaptic region and the low signal-to-noise ratio of imaging, its identification has always been a difficult problem to overco.
In the future, with the development and maturity of more technologies, it is hoped that the regulatory mechanism of RNA in the synaptic region will be further studi.
In conclusion, this study found that the RNA-binding protein Mub enhances the translation of CaMKII in the synaptic region, which is necessary for the formation of associative learning and memory (F.
Original link: https://autho.
elsevi.
com/c/1f2ob3QW8R~cbw This article was supported by NIH R37 NS112810 (Leslie.
Griffith) and NIH R01 DA043195 (Leslie.
Griffith) fun.
The first author is Chen Nannan (the second from the left in the upper row), and the corresponding author Leslie.
Griffith (the first from the left in the upper ro.
He received his .
from the Institute of Biophysics, Chinese Academy of Scienc.
After graduation, he did post-doctoral research in the Griffith Laboratory of Brandeis Universi.
About the Communications Lab: The Griffith Lab (https:// at Brandeis University in suburban Boston is dedicated to studying the biochemical and cellular basis of behavi.
The laboratory is currently recruiting postdoctoral fellows, and applications from aspirants are welco.
Talent recruitment[1] "Logical Neuroscience" is looking for an associate editor/editor/operation position (online office) Selected articles from previous issues[1] Review of Front Aging Neurosci︱Fan Dongsheng's team focuses on peripheral and central immunity in amyotrophic lateral sclerosis Interaction of systems 【2】NPP︱Wei Lu’s team revealed a new mechanism of phosphorylation of auxiliary subunits of GABAA receptors to regulate neural behavior 【3】Cereb Cortex︱Pattern rigidity, temporal dynamics of ventromedial prefrontal cortex affect rumination and depression The role of [4] Front Aging Neurosci︱PTAFR as a novel biomarker to assist in the diagnosis and treatment of Alzheimer's disease [5] PNAS︱ Feng Guoping's laboratory reveals the important role of front thalamic circuits in working memory [6] Mol Psychiatry︱ Keqiang Ye’s group reveals that inflammation-activated C/EBPβ/AEP signaling pathway mediates high-fat diet-induced diabetes and Alzheimer’s disease 【7】PNAS︱ Changhe Wang’s group reveals synaptic exocytosis-endocytosis balance New Mechanism【8】Autophagy︱Ye Yihong’s research group revealed a new molecular mechanism of neuronal ceroid lipofuscin deposition: DNAJC5/CSPα gene mutation leads to lysosomal homeostasis imbalance【9】J Neuroinflammation | New evidence on the relationship of cerebral small vessel disease [10] Science︱Neural mechanism of non-cued goal-directed behavior High-quality scientific research training course recommendation [1] Academic paper writing practical training course (Live: 20221~22) [2] Single cell Symposium on Sequencing and Spatial Transcriptomics Data Analysis (Tencent Online Conference on June 11-12) [3] Symposium on Patch Clamp and Optogenetics and Calcium Imaging Technologies May 21-22 Tencent Conference Academic Symposium [1] Symposium Series︱Inside the Brain: Imaging Research References for Amygdala Circuits (swipe up and down to read) 1, Erondu, NE, and Kennedy, MB (198
Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat bra.
.
Neuros.
5, 3270–327 https://d.
org/11523/jneuros.
05-12-03271982, Griffith, LC, Verselis, LM, Aitken, KM, Kyriacou, CP, Danho,.
, and Greenspan, RJ (199
Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plastici.
Neuron 10, 501–50 https://d.
org/11016/0896-6273(93)90337.
3, Silva, AJ, Paylor,.
, Wehner, JM, and Tonegawa,.
( 199
Impaired spatial learning in a-calcium-calodulin kinase II mutant mi.
Science 257, 206–21 https://d.
org/11126/scien.
1321494, Bayer, KU, and Schulman,.
(2019.
CaM kinase: still inspiring at 4 Neuron 103, 380–39 https://d.
org/11016.
neur.
2010035, Aakalu,.
, Smith, WB, Nguyen,.
, Jiang,.
, and Schuman, EM (200
Dynamic visualization of local protein synthesis in hippocampal neuro.
Neuron 30, 489–50 https://d.
org/11016/s0896-6273(01)00295-6,Miller,.
, Yasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaste.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleYasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https ://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleYasuda,.
, Coats, JK, Jones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https ://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of articleJones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/ s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neurosc.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https:/ /d.
org/11523/JNEUROS.
1313-1201 End of this articleJones,.
, Martone, ME, and Mayford,.
(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/ s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neurosc.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https:/ /d.
org/11523/JNEUROS.
1313-1201 End of this article(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org /11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (2017.
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 This paper Finish(200
Disruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org /11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (2017.
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 This paper FinishDisruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016/.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3 'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paperDisruption of dendritic translation of CaMKIIa impairs stabilization of synaptic plasticity and memory consolidati.
Neuron 36, 507–51 https://d.
org/11016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Ce.
Neuros.
76, 33–4 https://d.
org/11016/.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3 'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper1016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Cel.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https ://d.
org/11523/JNEUROS.
1313-1201 End of article1016/s0896-6273(02)00978-7, Nesler, KR, Starke, EL, Boin, NG, Ritz,.
, and Barbee, SA (201
Presynaptic CamKII regulates activity-dependent axon terminal grow.
M.
Cel.
Neuros.
76, 33–4 https://d.
org/11016.
m.
2010008, Kuklin, EA, Alkins,.
, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https ://d.
org/11523/JNEUROS.
1313-1201 End of article, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper, Bakthavachalu,.
, Genco, MC, Sudhakaran,.
, Raghavan, KV, Ramaswami,.
, and Griffith, LC (201
The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogast.
.
Neuros.
37, 10554–1056 https://d.
org/11523/JNEUROS.
1313-1201 End of paper
