-
Neurology: Inherited frontotemporal dementia, how does long-term cognitive function change?
Time of Update: 2022-08-19
They conducted a 5-year follow-up study to investigate baseline and longitudinal differences in neuropsychological test performance among C9orf72, GRN, MAPT pathogenic variant carriers and control participants, as measured by the CDR® NACC FTLD total score Pathogenic variant carriers were stratified .
-
Front.aging.neurosci- and α-synuclein are inseparable from the pathological progression of Parkinson's disease
Time of Update: 2022-08-19
Described the transformation process of α-syn in PD pathogenesis, including phosphorylation modification, aggregation and proliferation, and emphasized the important role of hypoxia in promoting α-syn pathology, aiming to interpret the role of hypoxia in PD development from a new perspective.
-
Current Biology: Why does using your brain make you tired?
Time of Update: 2022-08-19
Three years ago, research by Mathias Pessiglione's team, also published in Current Biology, showed that excessive exercise can also lead to mental fatigue, causing a decrease in activity including in the prefrontal cortex of the brain, an area critical for decision-making .
-
European Radiology: Are unenhanced CT signs that can indicate the progression of intracranial hematoma really reliable?
Time of Update: 2022-08-19
15 physicians and trainees (stroke neurology, interventional and diagnostic neuroradiology) were trained and identified 6 densities (Barras density, black hole, mixed, low density, liquid level, vortex) and 3 densities using standardized definitions Shapes (Barras shapes, islands, satellites) extended markers .
-
Movement Disordres - New PD Drugs Targeting Synuclein, How Effective?
Time of Update: 2022-08-19
The safety/tolerability and single-dose and multiple-dose PK of UCB0599 and its metabolites were investigated in two Phase 1 studies in healthy participants (HPs), in which food effects and its association with itraconazole (ITZ) were evaluated ) of possible interactions (UP0030 [randomized, placebo-controlled, dose-escalation, crossover study, N = 65] and UP0078 [open-label study, N = 22]) .
-
Two children die of liver failure after being treated with most expensive gene therapy drug Zolgensma, cause under investigation
Time of Update: 2022-08-19
On August 11, 2022, two children died of acute liver failure under further investigation after treatment with Novartis' (NYSE: NVS) gene therapy drug Zolgensma (onasemnogene abeparvovec) for spinal muscular atrophy in Russia and Kazakhstan .
-
Stroke, the leading cause of death among adults in my country, how to prevent it?
Time of Update: 2022-08-19
2. Scoring according to CHA2DS2-VASc: Stroke, commonly referred to as "stroke", is the second leading cause of death globally, after cardiovascular disease (CVD) .
2. Scoring according to CHA2DS2-VASc: Stroke, commonly referred to as "stroke", is the second leading cause of death globally, after cardiovascular disease (CVD) .
-
Tsinghua University Reveals the Important Function of the Mechano-receptor Piezo1 in the Mechanosensing of the Central Nervous System
Time of Update: 2022-08-19
" "Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions", revealed that Piezo1, as a mechanosensor of astrocytes, can convert mechanical signals into chemical signals, and participate in the regulation of adult hippocampus by affecting ATP release The important role of neurogenesis and cognitive function provides evidence for the involvement of mechanosignaling in regulating brain tissue homeostasis .
-
Changes in retina may be linked to part of brain at risk of Alzheimer's disease in healthy subjects
Time of Update: 2022-08-19
Video applet like, double-tap to cancel the like and watch, double-tap to cancel the view Correlations between the retina and various brain structures that are altered by the disease, such as the entorhinal cortex, the lingual gyrus, and the hippocampus, have been found in cognitively healthy subjects with high genetic risk for Alzheimer's disease.
-
The latest research progress of tDCS technology security, improving learning ability and cognitive ability
Time of Update: 2022-08-19
In a study of the safety of children's EEG devices at the University of Michigan School of Medicine, it was found that current densities exceeding a threshold are at risk of causing epilepsy .
-
Neurology case: isolated unilateral hypoglossal nerve palsy due to a meningioma at the base of the skull
Time of Update: 2022-08-19
Video applet like, double-tap to cancel the like and watch, double-tap to cancel the view A 73-year-old woman presented with intermittent slurred speech, drooling, and aspiration for 6 months .
-
Nature: Rewrite the textbook!
Time of Update: 2022-08-19
Video applet like, double-tap to cancel the like and watch, double-tap to cancel the view Water and food have rewarding properties, primarily because they satisfy the body's intrinsic needs .
-
Annals Neurology: Tau mediates synergistic effects of vascular risk and Aβ on cognitive decline
Time of Update: 2022-08-19
Previous studies have shown that higher baseline vascular risk and Aβ are synergistically associated with increased tau burden in the inferior temporal cortex (ITC) of older CU adults .
-
JAMA: Professor Chen Huisheng's team found that remote ischemic adaptation can improve functional outcomes in patients with acute and moderate ischemic stroke (RICAMIS study)
Time of Update: 2022-08-19
On August 16, 2022, a multi-center, randomized controlled study (RICAMIS study) led by Professor Chen Huisheng, director of the Department of Neurology of the Northern Theater General Hospital and chairman of the Liaoning Provincial Cerebrovascular Disease Clinical Medicine Collaborative Innovation Alliance (CDCIA), was conducted in the American Medical College.
-
Movement Disordres: α-synuclein V15A variant in familial Parkinson's disease exhibits weaker lipid-binding properties
Time of Update: 2022-08-19
V15A (hereafter referred to as V15A) from three affected individuals in two separate Japanese families of Parkinson's disease, a group found in a Caucasian population of potentially pathogenic variants 18 .
-
Express treatment of "ALS", stem cell therapy is about to submit a marketing application
Time of Update: 2022-08-19
▲If you have any business needs, please long press to scan the QR code above, or▎Edited by WuXi AppTec Content TeamToday, BrainStorm Cell Therapeutics announced that it plans to submit a Biologics License Application (BLA) to the U.
-
Science Advances: The most painful trigeminal neuralgia in humans, the therapeutic target is here
Time of Update: 2022-08-15
. This study shows that reactive oxygen species (ROS) accumulate in the cerebrospinal fluid of patients with trigeminal neuralgia, and they directly activate the pain ion channel TRPA1, which further identifies the NRF2 transcriptional network as a potential therapeutic target for trigeminal neuralgia .
-
Summary of Alzheimer's disease drug development pipeline
Time of Update: 2022-08-15
Drugs in Clinical Trials for Alzheimer's Disease in 2021 Clinical Phase III There are a total of 31 drugs in 47 Phase III trials (Figures 1 and 2, Table 1) .
6%) drugs in phase II trials were DMTs, including 26 biologics and 45 small molecules Seventy-one (86.
-
Cereb Cortex︱Pattern rigidity, the role of temporal dynamics in the ventromedial prefrontal cortex on rumination and depression
Time of Update: 2022-08-15
. Subsequently, the study investigated the spatial characteristics and temporal dynamic patterns of the DMN according to the data analysis process shown in Figure 1, and explored how the intraregional neural activity of the DMN affected rumination tendency and depression risk.
-
Brain Tumors in Children: New England Journal of Medicine Review
Time of Update: 2022-08-15
BRAF oncogene alterations in childhood low-grade gliomas* Poor response, especially when BRAF mutations are combined with homozygous deletion of the tumor suppressor gene CDKN2A .
BRAF oncogene alterations in childhood low-grade gliomas* Poor response, especially when BRAF mutations are combined with homozygous deletion of the tumor suppressor gene CDKN2A .
