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Parkinson's disease (PD) is the second most common neurodegenerative disease of the central nervous system, with an incidence of about 1%-2% in people over the age of 65, and the number of patients has continued to increase in recent year.
Researchers from the Beijing Institute of Encephalopathy, Capital Medical University, wrote a review summarizing the risk factors for PD, including genes, environment, aging, and TB.
Research result
The relationship between hypoxia and PD risk factors
The ability of nerve tissue to use oxygen decreases with age, while brain tissue requires more oxygen to meet its actual need.
Figure 1 Classification of hypoxia
Risk factors for hypoxia
From a pathophysiological point of view, hypoxia includes hypoxic hypoxia, blood hypoxia, and circulatory hypoxi.
Impaired oxygen utilization, also known as hypoxia, results from a decrease in the ability of cells and tissues to utilize oxyge.
α-Syn Pathology in PD
The etiology of PD is complex and there are many risk factors, but all of these risk factors may contribute to the occurrence of α-syn patholog.
Direct evidence of hypoxia and α-Syn pathology
Among these risk factors that directly contribute to PD pathology, there are disturbances in oxygen intake or utilizatio.
Hypoxia promotes α-Syn modification and aggregation and disseminatio.
Figure 2 Hypoxia is involved in the pathogenesis of α-synuclein (α-syn) and promotes its spread
However, sufficient attention and systematic research are still lacking in this field, and there are many unanswered questions: (1) the effect of hypoxia on the pathological proliferation of α-syn is not clear; (2) the degree, duration and pattern of hypoxia are still unclear Whether the differences in the results will affect the results; (3) whether it is possible to intervene in PD by resisting hypoxia or improving hypoxia toleranc.
Original link:M, Ji X and Liu J (2022) Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Diseas.
Reviewer: Simon (Brainnews Editorial Office)
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