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Correlations between the retina and various brain structures that are altered by the disease, such as the entorhinal cortex, the lingual gyrus, and the hippocampus, have been found in cognitively healthy subjects with high genetic risk for Alzheimer's diseas.
"Neuroscience News" July 26 news
This is the main conclusion of a study led by the Ramón Castroviejo Institute of Ophthalmology (IIORC) at the Complutense University of Madrid (UCM.
The novelty of the study, published in the journal Alzheimer's Research & Therapy, is that, for the first time, it examines the areas of the retina and those most affected in Alzheimer's diseas.
The study was published in the journal "Alzheimer's Research & Therapy" (latest impact factor: 823) on June 4, 2022
"This means that the retina is an accessible tissue that may provide information about the state of the brain and the changes taking place within it," noted IIORC researcher Inés López-Cuenca, lead author of the stud.
The San Carlos Clinical Hospital and the Technical University of Madrid (UPM) participated in the UCM study as part of the COGDEM stud.
Next Steps: Study Vision
For the study, the researchers selected a group of patients whose father or mother had Alzheimer's disease and who had a mutation in the ApoEɛ4 gene that predisposes them to Alzheimer's diseas.
The IIORC performed eye examinations on them, including optical coherence tomography (OCT.
"We've seen that these participants have shown changes in certain areas of the retina measured with OCT, while MRI of the brain remains normal," López-Cuenca sai.
In addition to the structure of the retina, the UCM team is collecting data on patients' vision to discover how the visual network works during these still asymptomatic stages of the diseas.
references
Source: Complutense University of Madrid
Changes in the retina can be linked to parts of the brain of healthy subjects at risk of Alzheimer's
Reference:
López-Cuenca, .
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