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Annals Neurology: Tau mediates synergistic effects of vascular risk and Aβ on cognitive decline

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Figure 1: Paper cover image

Elevated vascular risk and cerebrovascular disease are very common with age, often coexist with AD pathology, and are increasingly recognized as important factors in AD-related cognitive declin.

With this, Wai-Ying .

They included 175 older adults (age 75±0 years) without cognitive impairmen.

Figure 2: The results of the paper

Elevated baseline FHS-CVD and Aβ had a significant interaction (P=004) with increased ITC tau accumulation, even in individuals with Aβ burden below the conventional threshold for amyloid positivit.

The significance of this study lies in the discovery that vascular risk interacts with subthreshold levels of Aβ to promote cognitive decline, in part by accelerating early neocortical tau accumulatio.

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