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Growing data suggest that vascular risk factors, such as obesity, hypertension , high cholesterol , and diabetes , are not only risk factors for cardiovascular disease, but also risk factors for dementia in Alzheimer's disease (A.
Growing data suggest that vascular risk factors, such as obesity, hypertension , high cholesterol , and diabetes , are not only risk factors for cardiovascular disease, but also risk factors for dementia in Alzheimer's disease (A.
Figure 1: Paper cover image
Figure 1: Paper cover imageStudies have identified vascular risk and Aβ deposition as independent predictors of brain atrophy, suggesting that these two processes are associated with overlapping and distinct patterns of brain atrophy quantified by magnetic resonance imaging (MR.
Studies have identified vascular risk and Aβ deposition as independent predictors of brain atrophy, suggesting that these two processes are associated with overlapping and distinct patterns of brain atrophy quantified by magnetic resonance imaging (MR.
Vascular risk factors were primarily associated with atrophy in frontal and temporal regions, whereas Aβ deposition was most frequently associated with preferential cortical thinning in medial parietal and temporal regio.
Furthermore, it remains unclear whether vascular risk factors exacerbate brain atrophy through white matter changes, or whether this occurs through an independent pathw.
Here, Jennifer.
Brain atrophy was longitudinally quantified with structural magnetic resonance imaging over a median duration of 50 (±26) yea.
Figure 2: The results of the paper
Figure 2: The results of the paperIn a subsequent model, they adjusted for markers of white matter damage to determine whether vascular risk accelerated brain atrophy independently of spread and FLAIR-based marke.
In a subsequent model, they adjusted for markers of white matter damage to determine whether vascular risk accelerated brain atrophy independently of spread and FLAIR-based marke.
The significance of the study is the finding that higher vascular risk and elevated Aβ burden interact to predict more severe atrophy in the frontal and temporal lobes, thalamus and striat.
Higher Aβ burden, but not vascular risk, was associated with more severe atrophy of the parietal and occipital lobes and hippocamp.
Adjusting for diffusion- and FLAIR-based markers of white matter damage had little effect on these associatio.
The significance of the study lies in the discovery of an interaction between elevated vascular risk and higher Aβ burden and longitudinal brain atrophy, which in turn affects cognitive decli.
Original source:
Original source:Rabin JS, Pruzin J, Scott M, et .
Rabin JS, Pruzin J, Scott M, et .
Association of β-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrop.
_Neurolog.
2022;99(3):e270-e28 doi:[11212/W.
0000000000200551]( https://d.
org/11212/W.
0000000000200551) Association of β-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrop.
_Neurolog.
2022;99(3):e270-e28
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