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Click on the blue word to follow us Rapid Eye Movement (REM) sleep is associated with the consolidation of emotional memory: activation of specific neuronal populations in the cortex and hippocampus during sleep enhances synaptic plasticity and dendritic activity, ultimately consolidating memory trac.
However, memory forgetting also occurs during sleep, which is associated with pruning of dendritic spines and weakening of synaptic function in the prefrontal cort.
Local microcircuits exist in the prefrontal cortex: parvalbumin (PV) interneurons exert feedforward inhibition by innervating pyramidal neuron cell bodies; vasoactive intestinal peptide (VIP) interneurons selectively inhibit growth arrest The synapses of SST neurons are mainly located on the dendrites of pyramidal neuro.
On May 13, 2022, the research team of Antoine Adamantidis, Department of Neurology and Neurology, University Hospital of the Island of Bern, Switzerland revealed that local inhibitory microcircuits in the dorsal prefrontal cortex maintain memory consolidation during sle.
Decoupling changes in pyramidal neuron soma and dendrites in the dPFC region sustain sleep-related memory consolidati.
Two-photon in vivo calcium imaging revealed decreased soma activity in dorsal prefrontal cortex (dPFC) pyramidal neurons during REM, whereas However, the apical dendritic activity was increased, indicating the existence of sleep-related neuronal cell body activity and dendritic activity decoupling chang.
Figure 1: Changes in inhibitory microcircuits in the dPFC region during REM Further by calcium imaging, it was found that the activities of PV and VIP neurons in the dPFC region increased during REM, and the activity of SST neurons was weakened, indicating that the dorsal forehead was altered during R.
Local inhibitory/excitatory balance in leaf cort.
The dendrite activity of pyramidal neurons was also significantly decreased after photoinhibition of VIPergic neurons in the dPFC region during REM, indicating that VIPergic neurons caused the disinhibition of pyramidal neuron dendrit.
Mice undergoing sound-cued fear training had increased stiffness rates after hearing sound stimu.
However, after inhibiting the activity of VIPergic neurons in the dPFC during REM, the rigidity rate of mice did not increase after hearing sound stimuli, and they could not correctly identify sound cues; while after PV neurons were inhibited, mice heard sound stimu.
Post-rigidity was higher, indicating an enhanced ability to recognize vocal cu.
In vitro electrophysiological experiments found that the AMPA/NMDA ratio of pyramidal neurons in the dPFC region of photoinhibited VIPergic neuron activity was significantly reduced, indicating the inhibitory effect of local synaptic plasticity; while the AMPA/NMDA ratio after inhibition of PVnergic neuron activity markedly increased, indicating an enhancement of local synaptic plastici.
The mechanism of synaptic plasticity explained that inhibition of VIPergic neuron activity during REM weakened memory, and inhibition of PVergic neurons enhanced memo.
Two Neural Circuits Regulating REM-related Local Inhibitory/Excitatory Transitions Through virus tracer experiments, we found that PV neurons in the dPFC region received neurons from the centromedial thalamus (CM), the granule-deficient area of the retrograde cortex, and the retrograde cort.
The neurons in the granular area and primary somatosensory barrel cortex innervate single synapses, and VIPergic neurons receive input from most areas of the whole brain, but receive very little input from the CM area; pyramidal neurons do not receive input from the CM ar.
Figure 2: The thalamic projection to the dPFC circuit regulates the local inhibitory circu.
Optogenetic activation of CM axons projecting to the dPFC elicits excitatory postsynaptic currents in PV neuro.
Two-photon in vivo calcium imaging further revealed enhanced axonal calcium activity from neurons in the CM region projecting to the dPFC during R.
To further confirm that the CM region neurons regulate the local microcircuits in the dPFC brain region, after photoinhibition of the CM region neuron activity during REM, two-color two-photon in vivo calcium imaging found that the activity of PV neurons in the dPFC brain region was reduced and pyramid.
Neuronal activity increased, suggesting that CM neurons regulate local microcircuits in the dPFC brain regi.
Collectively, decoupling of somatic and dendritic activity in the dorsal prefrontal cortex during REM sleep sustains the memory consolidation process, which relies on changes in the local inhibitory/excitatory balance in this regi.
【References】 Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep
However, memory forgetting also occurs during sleep, which is associated with pruning of dendritic spines and weakening of synaptic function in the prefrontal cort.
Local microcircuits exist in the prefrontal cortex: parvalbumin (PV) interneurons exert feedforward inhibition by innervating pyramidal neuron cell bodies; vasoactive intestinal peptide (VIP) interneurons selectively inhibit growth arrest The synapses of SST neurons are mainly located on the dendrites of pyramidal neuro.
On May 13, 2022, the research team of Antoine Adamantidis, Department of Neurology and Neurology, University Hospital of the Island of Bern, Switzerland revealed that local inhibitory microcircuits in the dorsal prefrontal cortex maintain memory consolidation during sle.
Decoupling changes in pyramidal neuron soma and dendrites in the dPFC region sustain sleep-related memory consolidati.
Two-photon in vivo calcium imaging revealed decreased soma activity in dorsal prefrontal cortex (dPFC) pyramidal neurons during REM, whereas However, the apical dendritic activity was increased, indicating the existence of sleep-related neuronal cell body activity and dendritic activity decoupling chang.
Figure 1: Changes in inhibitory microcircuits in the dPFC region during REM Further by calcium imaging, it was found that the activities of PV and VIP neurons in the dPFC region increased during REM, and the activity of SST neurons was weakened, indicating that the dorsal forehead was altered during R.
Local inhibitory/excitatory balance in leaf cort.
The dendrite activity of pyramidal neurons was also significantly decreased after photoinhibition of VIPergic neurons in the dPFC region during REM, indicating that VIPergic neurons caused the disinhibition of pyramidal neuron dendrit.
Mice undergoing sound-cued fear training had increased stiffness rates after hearing sound stimu.
However, after inhibiting the activity of VIPergic neurons in the dPFC during REM, the rigidity rate of mice did not increase after hearing sound stimuli, and they could not correctly identify sound cues; while after PV neurons were inhibited, mice heard sound stimu.
Post-rigidity was higher, indicating an enhanced ability to recognize vocal cu.
In vitro electrophysiological experiments found that the AMPA/NMDA ratio of pyramidal neurons in the dPFC region of photoinhibited VIPergic neuron activity was significantly reduced, indicating the inhibitory effect of local synaptic plasticity; while the AMPA/NMDA ratio after inhibition of PVnergic neuron activity markedly increased, indicating an enhancement of local synaptic plastici.
The mechanism of synaptic plasticity explained that inhibition of VIPergic neuron activity during REM weakened memory, and inhibition of PVergic neurons enhanced memo.
Two Neural Circuits Regulating REM-related Local Inhibitory/Excitatory Transitions Through virus tracer experiments, we found that PV neurons in the dPFC region received neurons from the centromedial thalamus (CM), the granule-deficient area of the retrograde cortex, and the retrograde cort.
The neurons in the granular area and primary somatosensory barrel cortex innervate single synapses, and VIPergic neurons receive input from most areas of the whole brain, but receive very little input from the CM area; pyramidal neurons do not receive input from the CM ar.
Figure 2: The thalamic projection to the dPFC circuit regulates the local inhibitory circu.
Optogenetic activation of CM axons projecting to the dPFC elicits excitatory postsynaptic currents in PV neuro.
Two-photon in vivo calcium imaging further revealed enhanced axonal calcium activity from neurons in the CM region projecting to the dPFC during R.
To further confirm that the CM region neurons regulate the local microcircuits in the dPFC brain region, after photoinhibition of the CM region neuron activity during REM, two-color two-photon in vivo calcium imaging found that the activity of PV neurons in the dPFC brain region was reduced and pyramid.
Neuronal activity increased, suggesting that CM neurons regulate local microcircuits in the dPFC brain regi.
Collectively, decoupling of somatic and dendritic activity in the dorsal prefrontal cortex during REM sleep sustains the memory consolidation process, which relies on changes in the local inhibitory/excitatory balance in this regi.
【References】 Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep
