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Neurology: Clinically relevant changes in cognitive outcomes in the preclinical and prodromal cognitive phases: implications for clinical Alzheimer's disease trials
Time of Update: 2022-09-07
Recently, a study published in Neurology attempted to establish the smallest clinically important differences (MCIDs) for commonly used cognitive tests using anchor-based and distribution-based methods, with the secondary goal of investigating compound cognitive measurements that best predict the smallest changes in the sum of clinical dementia scoring boxes (CDR-SB).
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How important are diet and physical activity to people with Parkinson's disease?
Time of Update: 2022-09-07
Recently, a blockbuster research paper was published in JAMA Network Open, pointing out that a healthy eating pattern and an active lifestyle are associated with a lower risk of all-cause mortality in patients with Parkinson's disease .
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Neurology: Ketamine for treatment of refractory status epilepticus in newborns and children
Time of Update: 2022-09-07
Recently, a study published in Neurology aimed to describe the effects of ketamine on RSE in children and newborns.
Recently, a study published in Neurology aimed to describe the effects of ketamine on RSE in children and newborns.
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There is no way back! Pesticide residues in staple foods can induce Alzheimer's disease
Time of Update: 2022-09-07
These results suggest that when performed in vitro testing using primary cortical neurons derived from APP/PS1 mice, the level of glyphosate exposure detected in the brain in vivo was sufficient to increase Aβ40-42 levels and reduce cell viability in a dose-dependent manner.
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How does an injured brain recover on its own? Science: Scientists successfully constructed the world's first spatio-temporal atlas of brain regeneration
Time of Update: 2022-09-07
On September 2, 2022, BGI Life Sciences Research Institute, together with the team of Professor Fei Jifeng of Guangdong Provincial People's Hospital and the team of Professor Chen Liang of Wuhan University, published a research paper entitled "Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration" in science, a top international academic journal 。 The study mapped the first spatial-temporal atlas of salamander brain regeneration, which is also the world's first spatio-temporal atlas of brain regeneration.
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PNAS alert!
Time of Update: 2022-09-07
However, most studies have examined the effects of chronic ethanol exposure on the hippocampus and brain, and little is known about the acute neuronal correlates of key risk factors such as first-time intoxication .
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Drinking wine once can change your brain for a long time! PNAS: A single drunkenness can alter neurons, or develop into "alcohol addiction"
Time of Update: 2022-09-07
People who have never drunk alcohol may have a hard time understanding people who love alcohol, "beer is bitter, white wine is spicy", what is good about wine? In fact, for thousands of years, drinki
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JNNP: The effect of natalizumab on work performance in patients with multiple sclerosis
Time of Update: 2022-09-07
Natalizumab has been shown to be highly effective in slowing disability progression and reducing disease activity in multiple sclerosis (MS) in randomized controlled trials (RCTs) 1 2 and data studies, but few studies have evaluated natalizumab Anti-influence on patient-reported outcomes, especially compared to other disease treatments (DMT) .
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The data of the first trial of AAV gene therapy for Crabber disease was released, and there was already a corporate layout in China
Time of Update: 2022-09-07
September 1, 2022 / Medical McCity News eMedClub News/ -- Recently, Forge Biologics, a biopharmaceutical company focused on gene therapy, released the treatment data of the first patient in the Phase 1/2 RESKUE clinical trial of its research product FBX-101 for Krabbe disease, which initially proved the good efficacy and safety of FBX-101.
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Still wearing glasses to prevent blue light from hurting the eyes, what about the brain and aging? Studies have found that blue light can change metabolism to denature nerves and accelerate aging!
Time of Update: 2022-09-07
On the other hand, recent studies in Drosophila melanogaster have shown that long-term exposure to BL throughout the life cycle leads to accelerated aging, manifested by shortened lifespan and neurodegeneration of the brain, suggesting that BL can damage cells and tissues that are not specifically used for light sensing.
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HUMAN BRAIN MAPPING: Alzheimer's disease neuropsychiatric symptoms associated with multimodal brain networks
Time of Update: 2022-09-06
, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, focusing on four goals: (1) to identify multimodal brain patterns associated with NPS total score in AD;(2) Assess between-group differences in these identified regions;(3) Evaluate the predictive ability of identified brain patterns to cognitive changes;(4) Identify common and unique multimodal attributes of the four neuropsychiatric sub-syndromes (psychotic, affective symptoms, hyperactivity, apathy) .
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JAMA Neuro: Different temporal trends in stroke incidence in young versus older adults
Time of Update: 2022-09-06
references:Diverging Temporal Trends in Stroke Incidence in Younger vs Older People, A Systematic Review and Meta-analysis Overall stroke incidence in high-income countries is declining, but data on temporal trends in the incidence of young stroke (ie, stroke in individuals under 55 years of age) are conflicting .
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Neurology: E-type apolipoprotein and markers of cerebrovascular disease in patients with cerebral hemorrhage
Time of Update: 2022-09-06
0000000000200851 A study published in Neurology investigated the relationship between neuroimaging markers of apolipoprotein E-type (APOE), intracerebral hemorrhage (ICH), and cerebral amyloid angiopathy (CAA) .
0000000000200851 A study published in Neurology investigated the relationship between neuroimaging markers of apolipoprotein E-type (APOE), intracerebral hemorrhage (ICH), and cerebral amyloid angiopathy (CAA) .
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European Radiology: 3T MR neuroimaging of the lumbosacral plexus with ATTRv-PN
Time of Update: 2022-09-06
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
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Neurology: What do you know about gait disturbances in Parkinson's disease patients and compensation strategies?
Time of Update: 2022-09-06
from the University of Nijmegen, The Netherlands, assessed the efficacy of five different compensatory strategies: external cues, internal cues, movement observation, motor imagery, and adoption of new walking patterns .
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Nature sub-journal: Anti-aging vaccine coming?
Time of Update: 2022-09-06
Recently, a research team from Juntendo University in Japan published a research paper entitled: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice in the journal Nature Aging [2] .
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Hypertension: Association of blood pressure fluctuations during hospitalization for ischemic stroke with 3-month clinical outcomes
Time of Update: 2022-09-06
CONCLUSIONS: Larger blood pressure fluctuations during hospitalization were associated with an increased risk of adverse outcomes 3 months after the onset of ischemic stroke, independent of mean blood pressure .
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Movement disorders: Gender frequency differences in glucosidase variant carriers and familial Parkinson's disease
Time of Update: 2022-09-06
They assessed differences in sex-specific frequencies of GBA PD, including a subset of GBA variant severity, LRRK2 PD, and PD in the Ashkenazi Jewish cohort of idiopathic PD .
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Movement disorders: Xiangya Hospital: Can a dog sniff Parkinson's disease?
Time of Update: 2022-09-06
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study.
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Movement disorders: PM2.5 may induce Parkinson's disease
Time of Update: 2022-09-06
Air pollution exposure also induces α-Syn pathology within the OB of children and relatively young adults .
Air pollution exposure also induces α-Syn pathology within the OB of children and relatively young adults .
