Nature sub-journal: Anti-aging vaccine coming?

Written by | Wang Cong

Edit | Wang Duoyu

Typesetting | Shuichengwen

Aging is a natural process, all people will gradually age with age, it seems to be an irreversible natural law

Previous studies have shown that the aging process in life is partly due to the development of senescent cells, which have become difficult to function but have not died naturally.

In 2015, Dr.

Since then, numerous animal studies have shown that Senolytic therapy can improve aging status and prolong lifespan

Recently, a research team from Juntendo University in Japan published a research paper entitled: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice in the journal Nature Aging [2]

The study identified a target of senolytic therapy, the glycoprotein non-metastatic melanoma protein B (GPNMB), which has been shown to be enriched in senescent cells

Senolytic, a selective depletion of senescent cells, improves both normal and case changes associated with aging in mice

In this latest study, the research team identified the glycoprotein non-metastatic melanoma protein B (GPNMB) as a molecular target for senolytic therapy

GPNMB is a transmembrane protein, and analysis of transcriptomic data from senescent vascular endothelial cells revealed that GPNMB is enriched on the surface of senescent cells

As early as May 6, 2019, Song Baoliang's team from Wuhan University and Qi Wei's team from ShanghaiTech University jointly published a research paper entitled: Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance in the journal Nature Metabolism 【3】

This study shows that GPNMB is an important regulator in adipogenesis, GPNMB increases fatty acid synthesis in white adipose tissue and exacerbates diet-induced obesity and insulin resistance

The new study in Nature Aging confirmed that knocking out GPNMB can reduce metabolic abnormalities and atherosclerosis in mice fed a high-fat diet, and improve aging status

The research team then developed antibodies targeting the GPNMB protein as a vaccine

Next, the research team validated the vaccine in a mouse model of atherosclerosis, a disease caused by the accumulation of senescent cells, and in aging mice

In addition, the Senolytic vaccine also extended the lifespan of mice (by an average of 20%), especially in male mice

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