There is no way back! Pesticide residues in staple foods can induce Alzheimer's disease

Abnormal TNFα signaling is associated with many pathologies, including cancer, rheumatoid arthritis, psoriasis, multiple sclerosis, and immune, inflammatory, and neurodegenerative diseases

On July 28, 2022, the Arizona State University research team published a paper at the Journal of Neuroinflammation titled "Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders.

Figure 1 Research results (Source: [1])

The study, which involved 48 mice (24 males and females), explored whether glyphosate penetrated the brain and increased TNFα levels

Figure 2 Study design (Source: [1])

The results found:

01 Glyphosate exposure leads to simultaneous detection of glyphosate and its metabolites in the brain

Glyphosate exposure dose had a significant main effect on the measurement of glyphosate in the brain, and increasing the dose led to an increase in glyphosate levels in the brain (P <0.

02 Glyphosate exposure increases peripheral plasma and brain TNFα levels in a dose-dependent manner

Glyphosate exposure doses had significant main effects on TNFα levels in brain, hippocampal, and cortical homogenates, and TNFα levels increased

03 Brain glyphosate levels are associated with peripheral plasma and brain TNFα levels

Glyphosate levels were significantly positively correlated with TNFα levels in the brain, peripheral plasma, and urine, with glyphosate levels associated with peripheral TNFα levels, and glyphosate levels associated with peripheral plasma and brain TNFα levels

04 Glyphosate exposure in APP/PS1-derived primary cortical neurons increases the level of soluble amyloid beta 40-42 and reduces cell viability

Aβ levels are a hallmark

05 Glyphosate exposure results in dose-dependent transcriptome dysregulation

To characterize changes in the transcriptome after glyphosate exposure, the researchers isolated RNA from mouse brains and sequenced them by 100 bp double-ended sequencing on Illumina HiSeq 2500

This study shows that glyphosate can penetrate the blood-brain barrier, penetrate into brain tissue, and lead to elevated levels of the pro-inflammatory cytokine TNFα; In addition, treating cortical neurons with dose doses of similar glyphosate detected in vivo mouse brains was able to increase Aβ40-42 levels and reduce in vitro cell viability of primary cortical neurons; Glyphosate in the brain is associated with elevated levels of TNFα, suggesting that exposure to this herbicide may trigger neuroinflammation in the brain, which may lead to changes that occur in neurodegenerative diseases; This is further supported by the RNAseq findings, which show dysregulation

Glyphosate exposure may lead to early onset or accelerated progression

Resources:

[1] Winstone JK, Pathak KV, Winslow W, et al.