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Lysosomal dysfunction exists in the brains of patients with Parkinson's disease, while the accumulation and aggregation of α-syn is the main pathogenesis of PD
1.
As the second largest neurodegenerative disease in the world, there are more than 6.
However, the clinical use of this therapy cannot completely stop the progression of PD
2.
Synuclein is a 143 amino acid long neuron-specific presynaptic protein
A 1997 study showing a genetic link between the A53T mutation of α-syn and heritable forms of PD reinforces the hypothesis that α-syn is a key player in PD
3.
The proteasome system typically degrades proteins with shorter half-lives, while proteins with half-lives greater than 10 hours are degraded by the autophagy-lysosomal pathway
Figure 1: Autophagy-Lysosome Pathway
4.
Autophagy-lysosomal pathway (ALP) impairment is increasingly recognized as a key pathological event in neurodegenerative diseases
Therefore, scientists believe that lysosomal dysfunction may be the link between specific neuronal susceptibility, amyloidosis, and aging in PD
references:
Wildburger NC, Hartke AS, Schidlitzki Aand Richter F (2020) Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms.
Compilation Author: Level 10 Fatty (Brainnews creative team)
Reviewer: Simon (Brainnews Editorial Office)
