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Zebrafish Whole Brain Transcriptional Atlas Reveals Molecular Regulation Rules of Neuronal Phenotype
Time of Update: 2021-12-28
In this study, researchers from the Center for Excellence in Brain Intelligence of the Chinese Academy of Sciences completed single-cell sequencing of the whole brain, brain region specificity, specific neuromodulator / neurotransmitter neurons of the juvenile zebrafish, and mapped the juvenile zebrafish.
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Abnormal Ca2+ signaling of IP3R in adipocytes is related to inflammation and metabolic disorders in obesity
Time of Update: 2021-12-28
Inflammation caused by obesity in vitro or in vivo can lead to increased abundance and activity of IPthreePhosphorylation of Rs and CaTwo+-The dependent kinase CaMKII in adipocytes is dependent on the kinase JNK .
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Uveal melanoma-PLCβ4 related mutations constitutively activate and promote melanocyte proliferation and tumorigenesis
Time of Update: 2021-12-28
It was found that these mutations constitutively activated PLCβ4 and related subtypes, and the proliferation of melanocytes expressing these mutants was enhanced .
These results are consistent with PLCβ4 (D630Y) driving oncogenic signals downstream of GαQ11.
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The first patient-specific zebrafish model for arrhythmic cardiomyopathy
Time of Update: 2021-12-28
By introducing a mutation in a gene called phosphoprotein (PLN) pa arg14del in zebrafish, they were able to reproduce the human form of the disease .
"By using this drug, we were able to restore certain heart cell changes caused by PLN mutations," Carmel said .
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"Cell Stem Cell" so far the most complicated stomach organ was born, and human transplantation will be realized within 10 years!
Time of Update: 2021-12-28
This research developed the most complex stomach organ to date, which has unique glands and nerve cells that can control smooth muscle contraction .
Therefore, the germ layer components isolated from pluripotent stem cells can be used in tissue engineering to generate complex human organoids .
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Study on Regulation of Hyperimmune Disease Related Gene CCL17
Time of Update: 2021-12-28
Figure: A group of scientists from the University of Texas recently clarified the complex CCL17/TARC chemokine regulation pathway, revealing insights that can help us design new therapies for immune system-related diseases .
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Lang Zhaobo's research group developed an efficient dicot adenine single-base editor
Time of Update: 2021-12-28
In addition, the researchers have also expanded the Cas9 variant system of the single-base editor driven by pSlEF1α , which can also achieve precise editing of some NG PAM sites in dicotyledonous plants such as Arabidopsis, tomato, and soybean .
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There is a new understanding of why exercise is good for the brain
Time of Update: 2021-12-28
They also found that after 6 months of physical exercise intervention, the levels of cluster protein in the plasma of 20 patients with mild cognitive impairment increased .
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Nature Sub-Journal: Looking for new channels to selectively target pests
Time of Update: 2021-12-28
Figure: Schematic diagram of Slo in the Ca2+ non-activated conformation (left) and Ca2+ combined activation conformation (right) The common slow poke potassium ion channels in Drosophila are huge and complex proteins located in the cell membrane.
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Young people got Parkinson's disease after contracting the new crown!
Time of Update: 2021-12-28
In the journal ACS Chemical Neuroscience under the American Chemical Society, researchers found that the N protein of the new coronavirus can interact with α-synuclein to accelerate the formation of amyloid deposits .
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Scientists use ostrich egg antibodies to develop new crown masks
Time of Update: 2021-12-28
Science and Technology Daily, Beijing, December 14 (Intern reporter Zhang Jiaxin) According to recent news from Japan’s "Japan Times" and British "Daily Mail", the development team chaired by Yasuhiro Tsukamoto, president of Kyoto Prefecture University in Japan, used antibodies extracted from ostrich eggs to develop A mask to detect the new crown virus has been developed .
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mRNA therapy: the development of an HIV vaccine reduces the risk of infection in rhesus monkeys by 79%
Time of Update: 2021-12-28
Experiment with neutralizing antibody levels in rhesus monkeys over time (Source: Nature Medicine)The research team tested the Env-Gag VLP mRNA vaccine on rhesus monkeys .
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Second successful pig kidney xenotransplantation
Time of Update: 2021-12-28
Less than two months after the first breakthrough operation, the New York University Langone Health Center performed a second experimental xenotransplantation using genetically engineered pig kidneys .
He transplanted a pig kidney lacking the alpha-galactose gene to a donor who had recently passed away on a ventilator .
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How food intake changes the gut
Time of Update: 2021-12-28
Today, by using different mouse models in combination with human intestinal biopsies, they have deciphered the molecular mechanisms that control this surprising organ plasticity and found that increasing the amount of food can improve the absorption surface and function of the intestine .
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Better treatment options for patients with advanced colorectal cancer
Time of Update: 2021-12-28
The City of Hope, a world-renowned cancer research and treatment organization in California, today announced the results of a phase II clinical trial, demonstrating that sotorasib monotherapy has good anti-tumor effects in severely treated patients with advanced colorectal cancer Activity and good yield .
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It is expected to change the treatment model of first-line lymphoma Roche ADC combination reduces the risk of disease progression by 27%
Time of Update: 2021-12-28
On December 14, 2021, Genentech, a Roche subsidiary, announced that the "first-in-class" CD79b-targeted antibody-conjugated drug (ADC) Polivy (polatuzumab vedotin) will be linked to a treatment program called R-CHP It has been used in the first-line treatment of patients with diffuse large B-cell lymphoma (DLBCL) in Phase 3 clinical trials with positive results .
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Breakthrough success!
Time of Update: 2021-12-28
Image source: The University of Hong KongThe research results will be published in the "Journal of Chemical Engineering" on November 25, 2021, entitled "Anti-pathogen stainless steel combating COVID-19" .
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Cell Rep: Improved drug choice for patients with colorectal cancer
Time of Update: 2021-12-28
Now, Assistant Professor Salk and internal medicine scientist Edward Stites uses computer modeling and cell research to find that more patients can be helped by a common targeted therapy, which is more than previously thought .
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Chronic obstructive pulmonary disease: a genetic mutation confirmed as a predisposing factor
Time of Update: 2021-12-28
In this context, scientists from the Paris Pasteur Institute (Université de Paris, CNRS, Inserm, Reims-Champaign-Ardenne), Reims University Hospital (Reims University Hospital) and French Pasteur de Lille Institute (Institut Pasteur de Lille) proved that replacing a single nucleotide in the gene encoding the nicotine acetylcholine receptor can cause changes in the function of airway cells and cause symptoms similar to COPD, independent of smoking .
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Nature Cancer: How to keep tumor cells dormant?
Time of Update: 2021-12-28
Researchers found that after adding this collagen to the environment around the cells, they can force the cells to stay dormant and prevent tumor recurrence .
This study shows that increasing the type III collagen in the tumor microenvironment can prevent cancer metastasis by activating tumor cell dormancy .
