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How the protein tangled in "Neuron" kills brain cells step by step and induces Alzheimer's disease
Time of Update: 2021-11-01
"The tau aggregates seem to isolate splicing-related RNA and proteins, disrupt their normal functions, and impair the cell's ability to make proteins," Lester said .
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Two "Nature" published together! How much do we still don't know about the new crown?
Time of Update: 2021-11-01
▲The serum of patients with severe COVID-19 will inhibit the function of natural killer cells in a TGFβ-dependent form (picture source: reference [1])Research and analysis found that in the first week of infection of the new crown in severely ill patients, they will produce a large number of TGFβ molecules in their bodies .
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Science journal: Osteocalcin hormone-mediated mechanism of oligodendrocyte myelination
Time of Update: 2021-11-01
A research team led by Li Xiang, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, revealed the molecular mechanism of OCN-mediated myelination of oligodendrocytes in the central nervous system .
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Researchers have discovered a new way to mark inpatient pharmacy orders
Time of Update: 2021-11-01
, New York University’s Technology Management and Innovation Professor Jingmai, Chen Ji, Eduardo Iturrate and Yindalon Aphinyanaphongs of New York University Grossman College (Grossman) and New York University Langone College (NYU Langone), developed a machine learning model that uses only provider behavior and others It may reflect the contextual characteristics of these new sources of inefficiency, rather than the patient’s medical records, to identify drug orders that require drug intervention .
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The first in 5 years!
Time of Update: 2021-11-01
On the 23rd, Roche announced that the US FDA has approved Susvimo for the treatment of patients with wet age-related macular degeneration (AMD) .
Retrieved October 22, 2021, from https:// news-release/2021/10/22/2319366/0/en/FDA-approves-Roche-s-Susvimo-a-first-of-its-kind-therapeutic-approach-for-neovascular-or-wet-age- related-macular-degeneration-nAMD.
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incredible! The unprecedented complex appearance of living bacteria
Time of Update: 2021-11-01
This research was published today (October 25, 2021) in "PNAS" and was completed in collaboration with scientists from the National Physical Laboratory, King's College London, Oxford University and Princeton University, revealing the bacteria with a protective layer- Gram-negative bacteria-there may be stronger spots and weaker spots on the surface .
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PLoS Biology: Artificial intelligence helps quantify enzyme activity
Time of Update: 2021-11-01
Image: A schematic diagram of the process of predicting the Michaelis constant of an enzyme using a deep learning method .
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Solid, liquid or gas?
Time of Update: 2021-11-01
Researchers at the Massachusetts Institute of Technology are analyzing images of tumors growing in the laboratory and patient biopsies to identify cellular fingerprints to indicate whether the tumor is more like a solid, liquid or gas .
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ASHG 2021: Male infertility may be related to these new mutations
Time of Update: 2021-11-01
Miguel Xavier, a postdoctoral researcher at the Institute of Biological Sciences at Newcastle University, said: "In the past, male infertility was studied under a recessive genetic model, but according to this method, a large part of the cases still cannot find the cause .
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Researcher Gao Peng’s group from the Quantum Materials Science Center of the School of Physics uses low-dose atomic imaging to reveal the structure and decomposition path of organic-inorganic hybrid perovskites
Time of Update: 2021-11-01
9" >Researcher Gao Peng’s research group and collaborators from the Quantum Materials Science Center and Electron Microscopy Laboratory of Peking University School of Physics used low-dose imaging technology to achieve the structural characterization of hybrid perovskite (CH 3 NH 3 PbI 3 ) on the atomic scale and reveal it The decomposition path .
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A study found that intake of essential amino acids can prevent dementia
Time of Update: 2021-11-01
In a study recently published in the journal Science Advances, Japanese researchers showed that a low-protein diet can accelerate brain degeneration in a mouse model of Alzheimer's disease .
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Research reveals potential new ways to fight urinary tract infections
Time of Update: 2021-11-01
Mysorekar said: "Through the UTI animal model, we proved that DMF can activate NRF2, suppress the immune response, limit the damage caused by bacteria to urothelial cells, and promote the activation of RAB27B, thereby removing bacteria from the bladder .
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EU approves Merck's Keytruda combined with chemotherapy for triple-negative breast cancer
Time of Update: 2021-11-01
KEYNOTE-355 (NCT02819518) is a randomized, placebo-controlled phase 3 trial that evaluated Keytruda in locally recurring unresectable or metastatic triple-negative breast cancer (TNBC) patients who had not previously received chemotherapy for advanced disease.
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New understanding of the genesis of the lower crustal high-speed body in the northeastern part of the South China Sea
Time of Update: 2021-11-01
The published two-dimensional active source seabed seismograph ( OBS ) deep exploration research results , using the Kriging interpolation method, obtained the quasi-three-dimensional velocity structure model of the northeastern South China Sea, and discussed the spatial distribution characteristics of the crustal velocity in the northeastern South China Sea.
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99% of people confuse bladder cancer and urothelial cancer...
Time of Update: 2021-11-01
According to the anatomical location, UC is divided into upper urinary tract urothelial cancer (renal pelvis, ureter) and lower urinary tract urothelial cancer (bladder, urethra).
In fact, in addition to bladder urothelial carcinoma, the pathological types of bladder cancer also include: squamous cell carcinoma, adenocarcinoma, clear cell carcinoma, small cell carcinoma, etc.
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Qi Yijun's research group from the School of Life Sciences discovered the function of tRNA-derived small RNAs in plant antifungal defense responses
Time of Update: 2021-11-01
Qi Yijun’s group from the School of Life Sciences, Tsinghua University used a newly developed small RNA sequencing method to systematically analyze the 5′ tRNA halves and 5′ tsRNAs in the model plant Arabidopsis thaliana, and found that 5′ tsR-Ala regulates the expression of the target gene CYP71A13 and The synthesis of phytoalexins, thereby regulating the plant's antifungal defense response .
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Why does immunotherapy fail frequently?
Time of Update: 2021-11-01
Yan Qin of Yale University School of Medicine and other scientists discovered a class of enzymes that play a key role in the immune escape of cancer cells: histone demethylase family KDM5 .
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PNAS: The clearest structure diagram of live E. coli so far released
Time of Update: 2021-11-01
The resulting molecular structure image on the surface of the bacteria shows that the entire outer membrane of the bacteria is packed with micropores formed by proteins that allow nutrients to enter but prevent toxins from entering .
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Nanomedicine based on ferritin for targeted leukemia treatment
Time of Update: 2021-11-01
Image: CD71 expression in leukemia cells, construction of As@Fn and analysis of targeting ability Researchers from the Institute of Process Engineering of the Chinese Academy of Sciences, Peking University and Zhujiang Hospital of Southern Medical University have developed a ferritin (Fn)-based nanomedicine for targeted delivery of arsenic (As) and effective treatment of multiple types of leukemia .
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Researchers have discovered that carnivores may adjust their schedules to avoid each other
Time of Update: 2021-11-01
Nakabayashi said: "Information about the temporal activity patterns of animals is essential to assess the response to human disturbance and implement appropriate protective measures .
