-
In the genes related to growth, scientists have seen the dawn of human history
Time of Update: 2021-09-28
Gokcumen, associate professor of biological sciences at the University of Buffalo College of Arts and Sciences, said: “We think this variant is beneficial during hunger, which is the evolution of most humans .
-
3D tumor model is expected to achieve precise treatment of pancreatic cancer
Time of Update: 2021-09-28
David Osuna de la Peña, the first author of this article, said: "There are two main obstacles to the treatment of pancreatic cancer-the presence of high density of stromal cells and extracellular matrix and highly drug-resistant cancer stem cells (CSC) .
-
Why do apes have no tails?
Time of Update: 2021-09-28
According to a report in "Science" magazine, they found that a 300 base pair Alu element was inserted into the non-coding region of the TBXT gene in all great apes, but monkeys did not .
-
Childhood liver cancer actually originates from hepatoblasts!
Time of Update: 2021-09-28
Researchers at Hiroshima University analyzed molecular studies of nearly 160 cases of childhood liver cancer and discovered molecular markers that help understand and treat differences in prognosis .
This, coupled with the IGF2 methylation pattern similar to that of fetal liver, indicates that the "origin cell" is the hepatoblast .
-
Commemorating the 20th Anniversary of Human Genome Sequencing: Fu Qiaomei uses ancient DNA to decode human history
Time of Update: 2021-09-28
In 2010, the publication of three ancient genome drafts (namely Neanderthals, Denisovans, and a 4000-year-old modern man from Greenland) marked a new era in aDNA research .
In Eurasia, genome data was obtained from early modern humans as early as about 45,000 years ago .
-
Tumor models grown in the laboratory can improve the treatment of pancreatic cancer
Time of Update: 2021-09-28
Image: Confocal microscope showing pancreatic ductal adenocarcinoma (PDAC) cells, macrophages and pancreatic stellate cells embedded and grown in an engineered matrixAuthor: Professor Alvaro Mata, University of NottinghamAn international team of scientists created a three-dimensional (3D) pancreatic cancer tumor model in the laboratory, which combines a bioengineered matrix and patient-derived cells, which can be used to develop and test targeted therapies .
-
Newly discovered cause of hereditary heart disease
Time of Update: 2021-09-28
A research team led by University College London has discovered a new gene that can cause hypertrophic cardiomyopathy, an inherited heart disease that affects one in 500 people .
-
How does poxvirus turn genes into proteins?
Time of Update: 2021-09-28
A global vaccination campaign using vaccinia strains eventually led to the World Health Organization's announcement of the elimination of smallpox in 1980-this is the first time in human history that an infectious disease has been defeated on a global scale .
-
The Nobel Prize weather vane is here!
Time of Update: 2021-09-28
Clinical Medicine Research AwardClinical Medicine Research AwardReasons for the award: Katali Karikó from BioNTech and Drew Weissman from the University of Pennsylvania received the Lasker Clinical Medical Research Award .
-
Nature Cancer: Dual-target immunotherapy can effectively control neuroblastoma
Time of Update: 2021-09-28
Researchers at the Reinberg Comprehensive Cancer Center at the University of North Carolina recently reported a newly developed immunotherapy that uses modified immune cells to lock and attack two antigens or foreign substances on cancer cells at the same time, which is useful for implanting human nerves.
-
This intestinal bacterium promotes canceration of colon polyps
Time of Update: 2021-09-28
Bacteroides fragilis from polyp patients activates NF-κB through toll-like receptor 4, induces pro-inflammatory responses, and is rich in genes related to LPS biosynthesis .
Compared with bacterial isolates from healthy control patients, cells transfected with TLR4/MD2 and NF-κb-dependent firefly luciferase reporter gene, Bacteroides fragilis from polyp patients can activate TLR4 more significantly .
-
New small molecules can effectively reduce neuroinflammation in the brain and glial cells
Time of Update: 2021-09-28
"In the current study, co-authors with King, Nabors and Filippova, "SRI-42127, a new small molecule inhibitor of the RNA regulator HuR, effectively attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation," They are Rajeshwari Chellappan, Abhishek Guha, Ying Si, Thaddaeus Kwan, Xiuhua Yang, Anish S.
-
Gaofu team Cell Reports publishes research on new mechanism of GITR/GITRL identification
Time of Update: 2021-09-28
The complex structure of GITR/GITRL and the “DIV/KFS” motif that determines the binding specificity of GITR In recent years, the team has carried out a series of research work on the ligand recognition mechanism of immune checkpoint receptor molecules and the mechanism of antibody drug action.
-
Artemisinin-resistant malaria has emerged in Africa
Time of Update: 2021-09-28
Pascal Ringwald said that although the WHO has launched an active campaign to eliminate drug-resistant parasites in Southeast Asia through the rapid deployment of artemisinin-based combination therapies in affected individuals, it is considered that the disease is in The degree of spread in sub-Saharan Africa is unrealistic in the same way .
-
The enhancement of Sonic Hedgehog signaling prevents the sequelae of Parkinson's disease drugs
Time of Update: 2021-09-28
A new study led by the City University of New York shows that drugs that enhance sonic hedgehog (Shh) signaling can inhibit levodopa-induced dyskinesia .
Lauren Malave, the first author of this article, said: “In rodent and non-human primate models, the combined use of levodopa and sonic hedgehog agonists reduces the appearance of LID .
-
Boan Biotech brings CD3+ T-cell Engager patent platform and CEA/CD3 research results to the World Bispecific Antibody Summit
Time of Update: 2021-09-28
Boston, September 26, 2021/PRNewswire/ - Luye Pharmaceutical Group's holding subsidiary Boan Bio will present its CD3+ T- in the form of an oral report at the World Bispecific Summit 2021 (World Bispe
-
Improved microbial therapy obtains clinical proof-of-concept for the treatment of genetic and metabolic diseases
Time of Update: 2021-09-28
Recently, Synlogic announced that its microbial therapies SYNB1618 and SYNB1934 modified by synthetic biology have achieved positive results in a phase 2 clinical trial for the treatment of patients with phenylketonuria (PKU).
-
Science: Twist single domain antibody is effective against most COVID-19 variants
Time of Update: 2021-09-28
Twist Bioscience recently reported that the candidate antibody TB202-3 (CoVIC-094) found internally can effectively bind to a variety of new coronavirus (SARS-CoV-2) variants, including those with E484K, N501Y, D614G, Y453F and K417N mutant strains indicate that this therapeutic antibody may be effective against a variety of COVID-19 mutant strains .
-
Eating spinach has a significant anti-cancer effect through intestinal bacteria
Time of Update: 2021-09-28
The study found that in the rat colon polyp model through multi-omics techniques, eating spinach has a significant anti-cancer effect .
After feeding Pirc rats with freeze-dried spinach for 26 weeks, the research team observed significant anticancer activity in the colon and small intestine .
-
Nature Immunology: The fate of antibody-producing B cells may be "destined"
Time of Update: 2021-09-28
Another gene regulatory protein, OCA-B, triggers the genomic positions marked by OCT2 to become active, turning them into "super enhancers" and driving the rest of the B cell maturation regulatory network .
