 Home > Biochemistry News > Biotechnology News > Improved microbial therapy obtains clinical proof-of-concept for the treatment of genetic and metabolic diseases

Improved microbial therapy obtains clinical proof-of-concept for the treatment of genetic and metabolic diseases

 Last Update: 2021-09-28
 Source: Internet
 Author: User

Tags

food reduce diabetes

enzyme levels

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Recently, Synlogic announced that its microbial therapies SYNB1618 and SYNB1934 modified by synthetic biology have achieved positive results in a phase 2 clinical trial for the treatment of patients with phenylketonuria (PKU).

Phenylketonuria is an inherited metabolic disease.

Synlogic was co-founded by Dr.

The results of the phase 2 clinical trial showed that the fasting plasma phenylalanine level of patients receiving SYNB1618 treatment (dose of 1e12 live bacteria) decreased by 20% at 14 days.

▲The effect of SYNB1618 in reducing the level of phenylalanine (picture source: Synlogic official website)

SYNB1934 is an improved strain evolved from SYNB1618, which has a stronger ability to degrade phenylalanine

Image source: Synlogic's official website

Reference materials:

[1] Synlogic Announces Positive Phase 2 Data Demonstrating Reduction in Plasma Phenylalanine Levels in Patients with Phenylketonuria.

[2] Phenylketonuria Clinical Program Update 20 September 2021.

(The original text has been deleted)

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

L-Ascorbate-2-Monophosphate Feed Grade

CAS No.: 109620-90-8

Feed Grade

Potassium Sorbate from reliable manufacturer

CAS No.: 590-00-1

Food Grade

Doxycycline Hydrochloride

CAS No.: 10592-13-9

Pharmaceutical Grade

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.