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Yipinhong's wholly-owned subsidiary obtained the registration certificate of bromhexine hydrochloride injection
Time of Update: 2021-09-18
According to the approved drug instructions, the company's bromhexine hydrochloride injection is used for patients with chronic bronchitis and other respiratory diseases such as asthma, bronchiectasis, and silicosis who are difficult to cough up when oral administration is difficult .
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CRISPR gene editing therapy aimed at functional cure of HIV infection is about to start phase 1 clinical trial
Time of Update: 2021-09-18
EBT-101 is a CRISPR-based candidate therapy designed to functionally cure chronic type 1 human immunodeficiency virus (HIV-1) infection .
Reference materials:[1] Excision Receives FDA Clearance of IND for Phase 1/2 Trial of EBT-101 CRISPR-Based Therapeutic for Treatment of HIV.
Retrieved September 15, 2021, from https:// /09/15/2297456/0/en/Excision-Receives-FDA-Clearance-of-IND-for-Phase-1-2-Trial-of-EBT-101-CRISPR-Based-Therapeutic-for-Treatment-of -HIV.
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"Current Biology" hopes that all cows will learn to control the urination reflex to help reduce greenhouse gas emissions
Time of Update: 2021-09-18
"People usually think that cows have no ability to control defecation or urination," said co-author Jan Langbein (@niebgnal), an animal psychologist at the German Institute of Farm Animal Biology (FBN), but he and his team question this Idea .
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Xue Yongbiao's research group collaborates to reveal that wheat-specific transposons reshape the regulatory network of wheat environmental adaptation
Time of Update: 2021-09-18
Institute of Genetics and Developmental Biology Research Group Xueyong Biao, Zhang Jing Fudan University research group and the Chinese Academy of Sciences Innovation Center of Excellence in Molecular Plant Science / Shanghai Research Center for Plant Stress Biology Research Group Long Zhao Bo and Zhang Wenli, Nanjing Agricultural University research team used DNA pro and purified and sequenced ( the DAP-SEQ ) technology to obtain 53 genome environmental responsive transcription factor high binding pattern (FIG.
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A special subset of immune cells can reduce kidney damage
Time of Update: 2021-09-18
For example, special cells called mononuclear phagocytes (MNPs) play an important role in absorbing and processing damaged cells, removing invasive pathogens and other foreign bodies, and regulating immune responses .
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Huang Jianyong's research group from the School of Engineering has made progress in the treatment of bacterial infections by regulating the stiffness of the matrix
Time of Update: 2021-09-18
Jianyong Huang from the School of Engineering of Peking University published an online research paper entitled " Extracellular matrix stiffness modulates host-bacteria interactions and antibiotic therapy of bacterial internalization " in Biomaterials , revealing it from the perspective of mechanics and biology.
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Cancer immunotherapy gets the energy source of PIP
Time of Update: 2021-09-18
The researchers wrote: "Considering the potential of combination therapy in overcoming the current limitations of cancer immunotherapy, there is an increasing need for small molecule modulators that recognize immune cells that can enhance programmed cell death protein 1 (PD- 1) The effect of the blockade, which leads to better cancer treatment .
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Mortality rates for patients with opioid use disorders are similar to heart attacks
Time of Update: 2021-09-18
A new study from Oregon Health & Science University shows that hospitalized patients with opioid use disorder have a mortality rate equal to those with heart attacks within a year after discharge .
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Wu Bian's research group published a traceless protein enzymatic synthesis method at NSR
Time of Update: 2021-09-18
Figure 1 The current mainstream peptide splicing method leaves a "scar" at the connection site (gray amino acid in the figure) The team of researcher Wu Bian from the Institute of Microbiology, Chinese Academy of Sciences has long been engaged in the analysis and design reconstruction of the mechanism of microbial carbon and nitrogen bond-forming enzymes based on calculations .
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Scientists reveal the effects of chemotherapy on healthy cells
Time of Update: 2021-09-18
Núria López-Bigas, researchers at the IRB Barcelona Biomedical Genomics Laboratory found that in cases of acute myeloid leukemia (AML), platinum-based chemotherapy leaves a “footprint” (in the form of DNA mutations).
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Multi-center study of stem cell treatment of congenital heart disease
Time of Update: 2021-09-18
Richard Ohyi, director of cardiac surgery at the hospital and co-director of the Congenital Heart Center, said: "Research shows that stem cell therapy may have the potential to strengthen and improve the heart function of children who have no other treatment options .
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Roche and Novocure reach clinical collaboration for first-line treatment of pancreatic cancer
Time of Update: 2021-09-18
Novocure today announced that it has reached a clinical trial collaboration with Roche, combining Tumor Treating Fields (TTFields) with the anti-PD-L1 antibody Tecentriq for the first-line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC) .
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Cancer Research: Shanghai Institute of Medicine discovered a new mechanism for hypercholesterolemia to promote the development of bladder cancer
Time of Update: 2021-09-18
The research paper “aggressiveness by promoting cancer stemness” reports the mechanism by which oxidized low-density lipoprotein (ox-LDL) caused by hypercholesterolemia regulates the stemness of tumor cells and promotes the progression of bladder cancer .
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Science: Low-dose Moderna Covid-19 vaccine can trigger a long-lasting immune response
Time of Update: 2021-09-18
Sette said that the new study showed a strong CD8+ T cell response to the low-dose Moderna Covid-19 vaccine, similar to the response of patients to natural SARS-CoV-2 infection .
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Science Sub-Journal: Immune system neutrophils and macrophages cooperate to trap and kill bacteria
Time of Update: 2021-09-18
Researchers at the Vanderbilt Institute of Infection, Immunology and Inflammation hope that the newly discovered antibacterial mechanism can inspire new antiviral strategies against Staphylococcus aureus and other extracellular bacterial pathogens .
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New method makes 3D microscope imaging of human organs possible
Time of Update: 2021-09-18
Researchers at Umeå University in Sweden have now demonstrated a method by which specific cell types in human organs can be studied with micron-level precision .
Using this new method, researchers were able to demonstrate previously unrecognized anatomical and pathological features of the human pancreas, including areas with extremely high pancreatic islet density .
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"Unable to be a drug" target finally becomes history KRAS inhibitor breakout contest kicks off
Time of Update: 2021-09-18
Picture: AMG510Data source AmgenIn May 2021, Amgen's AMG510 (Sotorasib) was approved by the FDA for marketing, breaking the curse of KRAS "not a drug", and its indication is the second-line treatment of non-small cell lung cancer with KRAS G12C mutation .
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Science Signaling: These proteins have defeated emerging and recurring viruses
Time of Update: 2021-09-18
However, Shan-Lu Liu, professor of virology in the Department of Veterinary Biological Sciences at Ohio State University and senior research author, said that revealing that a protein has an enhanced effect on the necessary antiviral cell signaling pathways during host cell infection is completely different.
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One year of effective AIDS prevention therapy with a single medication, early clinical results are positive
Time of Update: 2021-09-14
Based on this positive result, Merck will launch a phase 2 clinical trial to further explore the potential of islatravir subcutaneous implants as long-acting pre-exposure prophylaxis (PrEP) therapy .
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For the first time, it has been shown that silent mutations can predict the development of cancer cells
Time of Update: 2021-09-13
In the current study, based on about 3 million mutations in the cancer genomes of 9915 patients, researchers tried to determine the type of cancer and predict the probability of survival 10 years after the initial diagnosis-based only on silent mutations .
