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Picture: Cancer (purple) patients are exposed to chemotherapy.
Certain types of chemotherapy eliminate cancer cells by destroying their DNA
Led by ICREA researcher Dr.
"In this work, we are particularly interested in identifying mutations caused by chemotherapy in healthy cells and understanding whether the onset of AML is before or after exposure to patient chemotherapy," said Dr.
Specifically, researchers were able to identify the "footprint" of platinum-based chemotherapy (cisplatin, oxaliplatin, and carboplatin) in the blood cells of patients with secondary AML
Clonal hematopoiesis and secondary AML
Clonal hematopoiesis is very common in the elderly.
"Our research allows us to distinguish whether clonal hematopoiesis has already begun before chemotherapy, thereby establishing a temporal relationship," said Dr.
Atlas of genetic changes caused by chemotherapy
In 2019, the Biomedical Genomics Laboratory (Biomedical Genomics Laboratory) published a paper that identified the "footprints" left by the six therapies commonly used to treat cancer in healthy cells
The study was successful because the patients and their families agreed to use the samples for scientific research
DOI
10.
The evolution of hematopoietic cells under cancer therapy
