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Rare cells, transiently activate cell regeneration
Time of Update: 2021-09-12
Benham Pyle said that when genes rich in these cell types are knocked out, "we found that they all promote regeneration in different ways, being activated at different times and in different parts of the body .
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"Cell Stem Cell" Small cell populations play an important role in triggering silent cases of hereditary MDS
Time of Update: 2021-09-12
In genetic mouse models, the biallelic DDX41 mutation causes the death of blood progenitor cells, leading to bone marrow failure and spleen atrophy .
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A high-fat diet destroys the biological clock, which may be the root cause of obesity
Time of Update: 2021-09-11
When mice are fed high-fat foods, they disrupt the brain's biological clock that normally controls satiety, leading to overeating and obesity .
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Demonstration of wrong nuclear DNA!
Time of Update: 2021-09-11
"Mesoscale phase separation of chromatin in the nucleus" by Gaurav Bajpai, Daria Amiad Pavlov, Dana Lorber, Talila Volk and Samuel Safran, 4 May 2021, eLife.
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Telomere dysfunction and chromosomal instability in cancer cells
Time of Update: 2021-09-11
Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells".
The authors found that treatment of cancer cells with Pt-cpym, Pt-vpym, Pt-ttpy or Pt-tpy will induce telomere dysfunction, leading to high chromosome instability .
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Unlike other primates, the reason why humans don’t eat insects raw
Time of Update: 2021-09-11
In order to use leaves as a new source of protein, the ancestors of large primates (including humans) developed umami taste receptors as glutamate receptors .
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The team from the Second Hospital of Zhejiang University found a potential target for the treatment of gastric mucosal injury
Time of Update: 2021-09-11
They found that ANKRD22 inhibition can drive the rapid proliferation of Lgr5+ gastric epithelial progenitor cells and reduce the inflammatory response after gastric mucosal injury .
Subsequent analysis showed that in the case of gastric mucosal injury, the absence of ANKRD22 promoted the rapid proliferation of Lgr5+ gastric epithelial progenitor cells (Figure 1) .
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Why does asthma worsen at night
Time of Update: 2021-09-11
Many behavioral and environmental factors, including exercise, air temperature, posture, and sleep environment, are thought to affect the severity of asthma.
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Can polygenic risk score predict schizophrenia?
Time of Update: 2021-09-11
They found that a commonly used tool in research to assess a person’s genetic risk of a certain disease, the polygenic risk score, is no better than a written report in predicting the outcome of a patient’s disease over time .
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"Nature Genetics" Investigation of Lung Cancer without a Smoking History
Time of Update: 2021-09-11
"Researchers including scientists from the National Institute of Environmental Health Sciences and other institutions published an article in the journal Nature Genetics entitled "Never Smokers Lung Cancer "Genomic and evolutionary classification of lung cancer in never smokers" paper, they concluded in the article, "Our findings indicate the development process of LCINS and possible new treatments .
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Nature Genetics releases large-scale eQTL analysis results, which help explain complex phenotypes
Time of Update: 2021-09-11
Joseph Powell, co-senior author and associate professor of the Gavin Institute of Medical Research, said: "In this study, we have deeply revealed how genes and diseases are related, providing a new perspective on gene regulation .
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TOP10 failed clinical studies in August 2021
Time of Update: 2021-09-11
Key research data (Source: Theravance)This multicenter, randomized, double-blind, placebo-controlled phase IIb dose exploration induction study (NCT03758443) aims to evaluate the clinical efficacy of oral Izencitinib once a day in the treatment of moderate to severe active ulcerative colitis in adults .
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Vaccination has entered a "critical period", what key points need to be paid attention to?
Time of Update: 2021-09-11
"In response to the implementation of two-code joint inspections of health codes and vaccination codes in some areas, measures to find people who have not been vaccinated as effectively as possible.
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Nature Sub-Journal: The first "Atlas" of human melanocytes
Time of Update: 2021-09-11
When further analyzing the atlas data, the researchers found that there are different types of melanocytes, including the origin cells of acral melanoma, which is a subtype of melanoma that mainly affects people of color .
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Nature Genetics: Reveal the origin of lung cancer in never-smokers
Time of Update: 2021-09-11
A genome analysis of lung cancer patients without a history of smoking found that most of these tumors are caused by the accumulation of mutations caused by natural processes in the body .
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Single-cell multi-omics analysis of plasma and immune cell metabolism changes related to the severity of COVID-19
Time of Update: 2021-09-11
After examining the blood samples of nearly 200 COVID-19 patients, the researchers discovered potential metabolic changes that regulate immune cells' response to the disease .
"The researchers collected 374 blood samples—two blood samples from each patient in the first week after the diagnosis of SARS-CoV-2 infection—and analyzed their plasma and individual immune cells .
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Tsinghua University Science published a paper, reporting the mechanism of RNA editing and regulation of kinases
Time of Update: 2021-09-11
Ou Guangshuo's laboratory used nematode cilia as the research object, and conducted research on over-activated protein kinases, and found that RNA editing can regulate over-activated ciliary kinases .
Genetic suppressor screening identified mutations in the adenosine deaminase responsible for RNA editing in the nucleus, which can rescue the cilia of DYF-5CA .
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Sun Yat-sen University: Improve the efficacy of refractory colorectal cancer, prolong survival, and optimize treatment strategies
Time of Update: 2021-09-11
As a clinical study of immunotherapy (PD-1 monoclonal antibody) combined with targeted therapy (regorafenib) in Chinese patients with microsatellite stable or low-grade unstable metastatic colorectal cancer, the research results have been published recently In Cell Reports Medicine, Professor Xu Ruihua is the corresponding author, and Chief Physician Wang Feng, Attending Physician He Mingming, Dr.
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Sinopharm submits new coronary pneumonia vaccine enhancement injection plan
Time of Update: 2021-09-11
He told reporters that Sinopharm China's bio-related experiments also showed that six months after the company completed the double-dose vaccine immunization program, enhanced vaccination can increase the antibody level of subjects by 5-10 times, which can be greatly improved .
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Some patients will be at risk of sequelae of COVID-19
Time of Update: 2021-09-11
But this optimistic view also brings a big problem: In some cases, COVID-19 can cause long-term complications, including breathing difficulties, fatigue and brain fog, and symptoms may last for at least a few months .
