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The immune response of COVID-19 patients is different, leading to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death
Co-first author Jihoon Lee, a graduate student at the Fred Hutchinson Cancer Research Center, said: “We know that there are a series of immune responses to COVID-19, but the biological processes of these responses are unclear
The researchers collected 374 blood samples—two blood samples from each patient in the first week after the diagnosis of SARS-CoV-2 infection—and analyzed their plasma and individual immune cells
In plasma samples, the team found that the increase in the severity of COVID-19 was related to changes in metabolites, indicating an increase in immune-related activities
"We found that metabolic reprogramming is highly specific to individual immune cell types (such as'killer' CD8+ T cells,'helper' CD4+ T cells, antibody-secreting B cells, etc.
DOI
10.
