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With the help of cutting-edge computer programs, researchers at the Icahn School of Medicine at Mount Sinai looked at the genetic and medical records of more than 8,000 schizophrenia patients
"Treatment of patients with schizophrenia is a heart-wrenching experience
Schizophrenia is a life-shortening mental illness.
Although this is a highly inherited disease, most cases cannot be related to a single gene
The polygenic risk score is a commonly used method for summarizing the genetic components of a person's disease risk
"The polygenic risk score basically adds up all the characteristics associated with complex diseases
First, the researchers compared the genetic and medical records of 762 schizophrenia patients
To this end, Dr.
They found that two of the results-aggressive behavior and the need for hospitalization-were significantly associated with higher polygenic risk scores
Follow-up experiments support these results
Finally, when they analyzed the genetic and medical records of 7779 patients in the genome psychiatry cohort of a large-scale project funded by the National Institutes of Health, they found the same trend
"Our findings indicate that more work needs to be done to use the potential of genetics to improve the treatment of patients with schizophrenia," said Dr.
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"Nature Medicine", DOI: 10.
