Telomere dysfunction and chromosomal instability in cancer cells

Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells".

The destruction of telomeres in drug therapy can lead to the specific instability of linear HAC

In this study, they used dual hac to analyze platinum-derived G4 ligand Pt-tpy and its five derivatives: Pt-cpym, Pt-vpym, Pt-ttpy, Pt-tpy and Pt-bisq

The increase in CIN after treatment with these compounds is related to the induction of double-strand breaks, which are mainly concentrated in telomeres, reflecting telomere-related DNA damage

These tripyridinplatin-derived G4 ligands are promising compounds for cancer treatment

Dr.

Telomerase/telomere targeted therapy is considered to be a potential cancer treatment, because even transient telomere dysfunction may cause chromosomal instability in human cells

Telomerase can lengthen telomeres, maintain the balance of telomere length, and prevent telomeres from becoming very short

In particular, the formation of G4s at telomeres will hinder the recognition of telomerase, inhibit telomere elongation, and cause telomere shortening

Therefore, telomeres are expected to be the target of discovering ligands that stabilize telomeres G4s, thereby disrupting telomere maintenance and causing genome instability

The authors found that treatment of cancer cells with Pt-cpym, Pt-vpym, Pt-ttpy or Pt-tpy will induce telomere dysfunction, leading to high chromosome instability

The Larionov/Kouprina research team concluded in their Oncotarget research output, “Using our dual-hac analysis, we identified three terpyridine platinum compounds, Pt-tpy, Pt-vpym and Pt-cpym, which are similar to those previously reported.

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