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These insights will help unravel the mystery of lung cancer in people without a history of smoking, and may guide the development of more precise clinical treatments
"What we see is that there are different subtypes of lung cancer in never-smokers with different molecular characteristics and evolutionary processes," said epidemiologist Maria Teresa Randy, MD, PhD in the Department of Integrated Tumor Epidemiology.
Lung cancer is the leading cause of cancer-related deaths worldwide
Environmental risk factors, such as exposure to second-hand smoke, radon, air pollution, and asbestos, or previous lung disease, can explain some lung cancers among never-smokers, but scientists still don’t know most of the causes of these cancers
In this large-scale epidemiological study, researchers used whole-genome sequencing to describe genomic changes in tumor tissues and matched normal tissues from 232 never-smokers (mainly European descent) who were diagnosed as non-small cells Lung cancer
Researchers combed the mutation characteristics of tumor genomes, which are mutation patterns related to specific mutation processes, such as damage caused by human natural activities (such as DNA repair defects or oxidative stress) or exposure to carcinogens
As expected, because the study was limited to people who had never smoked, the researchers did not find any mutations that were previously associated with direct exposure to tobacco
Dr.
Genomic analysis also revealed three new subtypes of lung cancer in non-smokers.
"We are starting to distinguish between subtypes that may have different prevention and treatment methods," Dr.
One of the future directions of this research is to study people of different ethnic backgrounds and geographic locations, and have a good description of their history of exposure to lung cancer risk factors
"We are just beginning to understand how these tumors evolved," Dr.
Dr.
Original search:
DOI
10.
Genomic and evolutionary classification of lung cancer in never smokers
