A high-fat diet destroys the biological clock, which may be the root cause of obesity

When mice are fed high-fat foods, they disrupt the brain's biological clock that normally controls satiety, leading to overeating and obesity

Since 1975, the number of obese people worldwide has almost tripled (1)

This new research may be the cornerstone of future clinical research that may restore the normal function of the biological clock in the brain and avoid overeating

Historically, people thought that the main biological clock was only located in the hypothalamus of the brain

Specifically, DVC has been shown to control food intake by inducing satiety

Studies have also shown that in obese people, the rhythm of daily food intake and the release of diet-related hormones will weaken or disappear

However, it is still unclear whether the failure of the brain center that controls appetite is the cause or the result of obesity

This new study, conducted by the Jagiellonian University of Krakow in collaboration with the University of Bristol, found that before the rats began to gain weight, the rats fed on a high-fat diet showed changes in the rhythm of DVC's daily neurons and the effects of these neurons on appetite hormones.

Therefore, the researchers proposed that the timing disorder of DVC leads to obesity, not the result of being overweight

The study was conducted on two groups of rats: one group was fed a balanced controlled diet (10% kcal fat), and the other group was fed a high-fat diet (70% kcal fat)

In order to simulate the impact of unhealthy diets on humans, the researchers introduced a new diet to adolescent rats (four weeks old), and monitored their food intake over a 24-hour period for four consecutive weeks

The changes of DVC neuron activity in 24h were measured by electrophysiological recording

Although the brainstems of humans and mice share common characteristics, the main limitation of the direct transformation of this study to humans is that it was conducted on nocturnal animals (mouse)

This study provides a new research opportunity to try to establish a DVC's biological clock function recovery strategy, thereby helping to solve the problem of obesity

Dr.

"I am very excited about this research because it offers the possibility to solve the growing health problem of obesity

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DOI

10.
1113 / JP281838

Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high-fat diet-implications for daily control of satiety