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The Guo Bin research group of the School of Basic Medical Sciences found that human cord blood functional hematopoietic stem cells were cultured in vitro under stress conditions...
Time of Update: 2021-09-11
Hematopoietic stem cell transplantation is currently one of the most mature and effective stem cell treatments . In 1988, the American scientist H. Broxmeyer and the French doctor E. Gluckman suc
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Scientists have discovered the mechanism of cardiac hypertrophy
Time of Update: 2021-09-11
Enrique Lara Pezzi, head of the CNIC Heart Failure Molecular Regulation Group and lead researcher, explained that these results revealed that “the protein SRSF4 binds to and stabilizes the non-coding RNA GAS5, enabling it to block the activity of glucocorticoid receptors, thereby preventing the heart Hypertrophy" .
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Telomere dysfunction and chromosomal instability in cancer cells
Time of Update: 2021-09-11
Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells".
The authors found that treatment of cancer cells with Pt-cpym, Pt-vpym, Pt-ttpy or Pt-tpy will induce telomere dysfunction, leading to high chromosome instability .
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Demonstration of wrong nuclear DNA!
Time of Update: 2021-09-11
"Mesoscale phase separation of chromatin in the nucleus" by Gaurav Bajpai, Daria Amiad Pavlov, Dana Lorber, Talila Volk and Samuel Safran, 4 May 2021, eLife.
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Nature Sub-Journal: There is a link between cell characteristics and childhood cancerous neuroblastoma
Time of Update: 2021-09-11
"In our study, we studied single-cell sequencing of healthy adrenal tissues from fetuses, infants, and older children, and compared them with tumor tissues from different neuroblastoma risk groups," Solner Said Susanne Schlisio, associate professor of microbiology, tumor and cell biology at Karolinska Institutet .
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New Israeli study: Inoculation of new crown vaccine booster significantly reduces the risk of infection
Time of Update: 2021-09-11
Xinhua News Agency, Beijing, September 7 (Reporter Zhang Ying) Two preprinted research papers recently published by Israeli researchers show that the third dose of Pfizer's new crown vaccine can significantly reduce the risk of new crown virus infection .
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Singapore researchers have developed a new 3D model to study vascular diseases
Time of Update: 2021-09-11
Professor Hou, the senior author of the study and associate professor at Nanyang Technological University's Lee Kong Chian School of Medicine, said: "Our new'on-the-chip' model can help clinicians better understand the basic biology and vascular dysfunction at the beginning of atherosclerosis.
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Protein LAG-3 is expected to predict which cancer patients will respond to immune checkpoint inhibitors
Time of Update: 2021-09-11
In a new study, researchers from the Memorial Sloan-Kettering Cancer Center in the United States found that specific patterns or "signatures" of markers on the surface of immune cells in the blood may be the result of immune checkpoint immunotherapy.
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Controlled studies have found that avocado can change the distribution of belly fat in women
Time of Update: 2021-09-11
Therefore, without relying on low-calorie diets and weight loss, dietary methods that promote visceral fat reduction and the risk of type 2 diabetes may have potential for overweight and obese individuals .
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Han Bin's research team revealed the five major female parent material groups and hybrid breeding trajectories of hybrid rice based on cytokine genome variation
Time of Update: 2021-09-11
On August 10, 2021, the Han Bin research group of the Center for Excellence in Molecular Plant Science of the Chinese Academy of Sciences published a study titled "Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform trajectory and strategy of hybrid rice breeding" in Molecular Plant .
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Artificial intelligence predicts Alzheimer's disease. The accuracy rate of the disease exceeds 99%!
Time of Update: 2021-09-11
Researchers at Kaunas University in Lithuania have developed a method based on deep learning that can predict the possible incidence of Alzheimer's disease through brain images with an accuracy rate of over 99% .
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New method makes it easier to predict algae growth
Time of Update: 2021-09-11
Now, a research team from the University of Gothenburg, in collaboration with the University of Oslo, has discovered a way to improve the ability to predict the reproduction of toxic algae .
"A simple analysis of the chemical markers of zooplankton in mussels can be used to improve predictions," said research leader Erik Selander .
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Mother has been infected with pathogens, and her children and grandchildren have known each other for four consecutive generations
Time of Update: 2021-09-11
In an early study, Murphy's laboratory found that infection with Pseudomonas aeruginosa allowed the nematodes to learn to avoid the bacteria, and that they could give offspring the impression of this avoidance behavior in the next four generations .
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new technology!
Time of Update: 2021-09-11
Studies in recent years have shown that extrachromosomal circular DNA (ecDNA) can promote the amplification of oncogenes, drive tumor evolution, and has genetic heterogeneity, which plays a key role in the occurrence of cancer [1,2,3,4] .
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Carcinogenic?
Time of Update: 2021-09-11
Earlier this year, when a patient who received an experimental gene therapy for hemophilia developed by the biotech company UniQure was diagnosed with liver cancer, people gradually became concerned about whether the carcinogenic risk of gene therapy would also play a role in humans.
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The "NgAgo" discovered by Chunyu Han proved to have low-temperature guided DNA nicking activity
Time of Update: 2021-09-11
1038/nature12971)In May 2016, China Han Chunyu identified another Ago protein (named NgAgo) derived from Natronobacterium gregoryi that can bind to guide DNA at 37°C and room temperature to achieve gene editing .
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How do patients with spinal muscular atrophy survive beyond "550,000 in 4 days"?
Time of Update: 2021-09-11
In the field of rare diseases, why has the annual treatment cost exceeded one million yuan become a norm?According to statistics, during the ten years from 2011 to 2020, the average success rate of rare disease (excluding tumor indications) drugs from phase 1 clinical trials to the approval of the US FDA for marketing is 17.
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One of the oldest and most endangered wolves in the world
Time of Update: 2021-09-11
The results of this study, published in the journal Molecular Ecology, revealed that the Indian wolf is one of the most endangered gray wolf populations in the world and is unique in evolution .
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"PNAS" why diabetes is closely related to severe COVID-19
Time of Update: 2021-09-11
Starting with a mouse model of coronavirus infection, they found that SETDB2 was reduced in immune cells called macrophages in the inflammatory response of diabetic mice .
"To verify this, the research team injected interferon into diabetic mice infected with coronavirus and found that they can increase SETDB2 and reduce inflammatory cytokines .
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Chinese scholars have made progress in the epigenetic regulation of vascular calcification
Time of Update: 2021-09-11
Figure 1 ALKBH1 activates BMP2 through demethylation modification to promote VSMC osteogenesis reprogramming With funding from the National Natural Science Foundation of China (approval numbers: 81870506, 81670676), the team of Professor Huang Hui of Sun Yat-sen University has made new progress in the epigenetic regulation of vascular calcification .
