Nature Sub-Journal: There is a link between cell characteristics and childhood cancerous neuroblastoma

Neuroblastoma is a childhood cancer that occurs in infants and young children

Neuroblastoma usually starts in the sympathetic nervous system or adrenal glands

Children’s age at diagnosis is one of the most important prognostic factors for a good prognosis

"In our study, we studied single-cell sequencing of healthy adrenal tissues from fetuses, infants, and older children, and compared them with tumor tissues from different neuroblastoma risk groups," Solner Said Susanne Schlisio, associate professor of microbiology, tumor and cell biology at Karolinska Institutet

Different cell types have different malignant tumor potential

Tumor tissue samples were collected from children aged 1 month to 6.

"We found that low-risk and high-risk neuroblastomas are composed of different cell types

The research team was able to match low-risk neuroblastoma with a cell type that grows during fetal adrenal development, while aggressive high-risk neuroblastoma and a type that can only be found in the adrenal tissue of the baby after birth Match the cell types

Analysis of these cell types also revealed that different gene expression programs that control survival conditions are related to age at diagnosis

"These special cells can help regenerate healthy tissues after birth, but when they become abnormal and cancerous, they may also be the culprits of aggressive neuroblastoma

Raising awareness helps reduce the occurrence of malignant tumors

Researchers will now expand their research to understand how the identified progenitor cell types are further changed after birth to create specialized cell types

"Understanding the details of this progenitor cell type, we may be able to make predictions and preliminary verifications of future treatment strategies based on tumor differentiation.

At the end of 2020, another study conducted by Schlisio's group in the same field was published in the journal Cancer Cell

Original search:

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

DOI

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