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Tsinghua University Science published a paper, reporting the mechanism of RNA editing and regulation of kinases

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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Protein kinases are not only involved in the regulation of eukaryotic cell division, differentiation and metabolism and other life processes, but also play a vital role in the physiological processes such as immune monitoring and individual behavior determination of multicellular organisms

On August 27, 2021, a research article entitled "RNA Editing Restricts Hyperactive Ciliary Kinases" (RNA Editing Restricts Hyperactive Ciliary Kinases) was published in the internationally renowned journal "Science".

This work shows that the information of kinase activity is negatively fed back to the kinase's own RNA, and its translation is inhibited by editing, thereby limiting kinase activity

RNA editing regulates activated DYF-5CA kinase activity

The Ou Guangshuo laboratory used genome editing to prepare a constitutively activated form of the nematode strain (DYF-5CA) of DYF-5 kinase.

The first author of the paper is Li Dongdong, a postdoctoral fellow in the School of Life Sciences, Tsinghua University, and the corresponding author is PI Ou Guangshuo, the Life Center

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