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On September 3, 2021, Huang Ruimin's team from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Yan Jun's team from Fudan University, together with Guo Hongqian's team from Gulou Hospital Affiliated to Nanjing University , published the title "Oxidized low-density lipoprotein links hypercholesterolemia and bladder cancer" in Cancer Research .
In today's society, changes in people's eating habits are one of the important reasons for the rapid increase in the number of people with metabolic syndrome in the world
In this study, the researchers first used two hypercholesterolemia mouse models (induced by high-fat and high-cholesterol feed or knocked out the Ldlr gene) to confirm that excess cholesterol in serum can increase bladder cancer transplanted tumors in mice As well as the tumor stemness of spontaneous bladder cancer, it promotes the development of bladder cancer
This study established for the first time the relationship between hypercholesterolemia and bladder cancer, proposed that ox-LDL may be a risk factor for the progression of bladder cancer, and revealed that ox-LDL in the serum of patients with hypercholesterolemia is an external system An important factor that regulates tumor stem-like cells sexually provides a powerful example of tumor macroenvironment's role in the regulation of tumor stemness
Figure 1.
Yang Lin, attending physician at Gulou Hospital of Nanjing University, and Sun Jingya, assistant researcher of Shanghai Institute of Materia Medica, are the co-first authors of this paper; Jun Yan, a young researcher at the Laboratory Animal Department of Fudan University, Huang Ruimin, researcher at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Gulou Hospital, Nanjing University Professor Hongqian Guo is the co-corresponding author of this paper
Link to the paper: https://cancerres.
(Contribution department: Huang Ruimin's research group, contributor: Sun Jingya)
