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"Optimized Herceptin" Margenza Head-to-Head Phase 3 Study Results Announced
Time of Update: 2021-09-20
CompilenewbornOn September 7, Zai Lab's partner MacroGenics announced the final overall survival (OS) results of the key phase 3 SOPHIA study (NCT02492711) of the HER2 targeted blocking antibody drug Margenza (margetuximab) for the treatment of adult patients with metastatic HER2-positive breast cancer.
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Science Sub-Journal: Platelets are the key to vascular injury in patients with COVID-19
Time of Update: 2021-09-20
. In order to support the theory that platelets are the core of vascular damage in COVID-19, the research team also presented evidence that drugs (clopidogrel or ticagrelor) that block platelet activation through platelet surface protein P2Y12 are known to reduce COVID-19 related Inflammation of blood vessels .
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Zhang Peng's research team collaborated to use dynamic network biomarker analysis to discover the molecular mechanism of sweet potato expansion (2021-08-30)
Time of Update: 2021-09-20
Zhang Peng's research group collaborated to use dynamic network biomarker analysis to discover the molecular mechanism of sweet potato expansionAugust 30, 2021, the State Key Laboratory of Plant Molec
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Nearly 200 million dollars!
Time of Update: 2021-09-20
Mammoth pioneered the development of these systems to help them overcome many of the obstacles faced by Cas enzymes and to facilitate delivery technologies for genome editing in vivo .
Reference materials:[1] Mammoth Biosciences Raises $195 Million to Build Next-Generation CRISPR Products in Therapeutics and Diagnostics.
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Nature Sub-Journal: Which gene can control colon cancer?
Time of Update: 2021-09-20
They studied the activity of Treg cells in mice lacking the gene and compared it with the activity of Treg cells in patients with colon cancer .
" Original search:TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer
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Development of tumor-infiltrating lymphocyte therapy to treat solid tumors Xinwei received $115 million in assistance
Time of Update: 2021-09-20
The funds obtained in this round of financing will be used to promote Obsidian's main tumor infiltrating lymphocyte (TIL) project cytoTIL15 into the clinic to obtain the first batch of clinical trial data for the treatment of metastatic melanoma .
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Nature discovers a new genetic form of ALS in children
Time of Update: 2021-09-20
In a study of 11 medical mystery patients, an international research team led by scientists from the National Institutes of Health and the United States Uniform Service University (USU) discovered a new and unique type of amyotrophic lateral sclerosis Disease (ALS) .
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FDA grants enpagliflozin to treat ejection fraction as a breakthrough therapy for heart failure
Time of Update: 2021-09-20
The results showed that, compared with placebo, empagliflozin reduced the relative risk of the composite primary endpoint of cardiovascular death or hospitalization for heart failure in adult patients with HFpEF by 21%, and the benefit was not related to ejection fraction or diabetic status .
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Another role of natural killer cells: coordinate wound healing
Time of Update: 2021-09-20
Picture: The skin lesions of mice lacking the signal factor HIF-1α in natural killer cells (right picture) showed a higher blood vessel density than normal mice (left picture) .
"We can genetically modify these cells in mice to accelerate the growth of blood vessels and make skin wounds heal faster .
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Persistence and Rescue: The Birth of China's First Approved RNA Therapy
Time of Update: 2021-09-20
In China, Noxinagen sodium is the first drug approved for the treatment of spinal muscular atrophy.
Now patients with spinal muscular atrophy in more than 50 countries and regions around the world can use this drug Get treatment .
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FRONT ECOL ENVIRON Yao Meng and Li Sheng's research team reported a new idea of using small and medium-sized carnivores such as leopard cats as biodiversity "collectors"
Time of Update: 2021-09-20
The study found that the abundance of small and medium-sized mammal species in leopard cat food is highly correlated with the species diversity recorded based on traditional method surveys, thus providing new ideas and ideas for non-damaging, rapid and accurate identification of regional biodiversity distribution information.
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Shanghai Jiaotong University innovatively proposed early diagnosis criteria for subclinical heart damage in patients with primary biliary cholangitis
Time of Update: 2021-09-20
This clinical study used CMR for the first time to explore whether there is cardiac involvement in primary biliary cholangitis in non-cirrhotic stage without cardiac symptoms, and reached an original conclusion .
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Cell reveals that the lack of such lymphocytes can protect cancer cells and resist tumor treatment
Time of Update: 2021-09-20
ILC3 in tumors and non-malignant adjacent tissues of patients with colorectal cancerSubsequently, the researchers conducted in-depth studies on the interaction between ILC3s and adaptive immunity in colorectal cancer, and observed that TH17 increased and TH1 cells decreased in tumors of patients and model mice .
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Two Nature Papers: The most comprehensive intestinal cell map to date, and the complete human developmental cell map
Time of Update: 2021-09-20
At the same time, Nature published an analytical paper, revealing how researchers from the HCA Developmental Biology Network plan to create a detailed roadmap for the reference map of the genome of cells, tissues and organs at different stages of healthy human development .
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Chinese Academy of Sciences scholar Cell Stem Cell published a paper: The physiological mechanism of adults no longer growing taller
Time of Update: 2021-09-20
On September 8, the international academic journal Cell Stem Cell published online the latest research progress of the Zhou Bo research group of the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences "Tracing the skeletal progenitor transition during postnatal bone formation" .
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The first single cell map of human intervertebral discs is released to provide clues to degenerative disc diseases
Time of Update: 2021-09-20
Liu Peng introduced that the human intervertebral disc single cell atlas will provide an important resource library for in-depth research in the field of intervertebral discs, lay a foundation for in-depth analysis of the physiology and pathological mechanisms of intervertebral discs, and provide important clues for the biological treatment of degenerative disc diseases .
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Death or non-death under stress is determined by the regulation of MK2 protein level
Time of Update: 2021-09-20
"When cells are exposed to high levels of stress, the p38-MK2 pathway is continuously activated to promote the degradation of MK2 protein, which is related to cell death .
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New tool counts T cells to quickly predict cancer immunotherapy response
Time of Update: 2021-09-20
Scientists at University College London (UCL) and the Francis Crick Institute in London have developed a new tool that can quickly estimate the number of T cells (immune cells) in cancer tumors*; with the abundance of T cells Degrees help predict the patient’s response to immunotherapy, and researchers hope this will enable more targeted and effective cancer treatments .
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Chinese Academy of Sciences Scholars Science Sub-Journal discovers key genes for iron content in plant seeds
Time of Update: 2021-09-20
September 4, 2021, Science sub-Journal Science Advances issued Innovation Center for Molecular Plant Sciences, Chinese Academy of Excellence Chao-generation Indian research group entitled "NPF transporters in synaptic-like vesicles control delivery of iron and copper to seeds" of research papers .
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Cell Journal: New drivers of obesity and inflammation have been discovered
Time of Update: 2021-09-20
In mice, researchers can only knock out DHP in macrophages and found that doing so can reduce inflammation and improve blood sugar control, even if the mice still become obese after eating high-fat foods .
