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A new mouse study led by researchers from the University of Chicago (UChicago) and Indiana University (Indiana University) showed that a protein called elF5A is a necessary factor in causing inflammation in obese macrophages
Their research results were published in the journal Cell Metabolism
"The metabolic inflammation (meta-inflammation) of obesity is characterized by the infiltration of pro-inflammatory macrophages into adipose tissue," the researchers wrote
The team tried to determine the role of DHPS in inflammation and obesity, because little is known about this protein
Dr.
Researchers pay attention to the downstream effects of e1F5A protein.
Rhagu Mimira, MD, professor of medicine at UChicago School of Medicine, said: “elF5A is important in the production of other proteins because it has an effect on mRNA translation, but it only works when the cell is under stress
In mice fed a high-fat diet and became obese, the expression of DHPS increased, and the activated form of elF5A, called elF5AHyp, was enriched in macrophages found in adipose tissue
Mirmira said: "We assume that this upregulation is unsuitable, so we think that if we block DHPS in mice, we might stop this process
The researchers observed that by knocking out DHPS, the overall translation of mRNA in inflammatory macrophages was reduced, and the secretion of some inflammation-related proteins was reduced
Mirmira said: "These results really allow us to separate simple weight gain from subsequent diabetes, which is usually seen in obesity
Mirmira said: "We know that in a high-fat diet, macrophages are more susceptible to inflammation.
The researchers were surprised to find that an enzyme may be the key to the behavior of macrophages
Researchers are looking forward to studying at least one small molecule that has been approved by the FDA for use in humans, which can block an enzyme upstream of DHPS
Mirmira said: "Obesity is a complex problem
Original search: Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype
