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The enhancement of Sonic Hedgehog signaling prevents the sequelae of Parkinson's disease drugs

 Last Update: 2021-09-28
 Source: Internet
 Author: User

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L-dopa (L-dopa) is currently recognized as the most effective treatment for Parkinson's disease

A new study led by the City University of New York shows that drugs that enhance sonic hedgehog (Shh) signaling can inhibit levodopa-induced dyskinesia

Dr.

Parkinson's disease (PD) is caused by the death of dopaminergic neurons, so levodopa is needed to treat this disease.

Shh was not considered a neurotransmitter in the past, but new papers show that it does act as a neuromodulator

Later, they used an animal model of Parkinson's disease to show that the death of dopaminergic neurons would lead to a decrease in Shh signals in the basal ganglia, which promoted the formation of LID

In the next step, the researchers intend to develop new therapies that act downstream of the Shh pathway of cholinergic neurons and carry out clinical trials

The corresponding author of the article, Professor Andreas Kottmann of the City University of New York School of Medicine, said: “Deep brain stimulation is not suitable for everyone.

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Malave, L.

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