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Nanjing University: Targeting the SHP2-DOK1-uridine axis can be used as a new strategy to improve osteoarthritis
Time of Update: 2021-11-01
Among them, the down-regulation of UPP1 expression and the most significant changes in DOK1 Tyr397 phosphorylation under SHP099 treatment .
Through verification, it is found that SHP2 promotes UPP1-mediated degradation of uridine through DOK1 Tyr397 dephosphorylation, and supplementation of uridine can improve OA by maintaining the balance of anabolism and catabolism .
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The coordination of the hands in the elderly requires more neural activity
Time of Update: 2021-11-01
A team of researchers from the Max Planck Institute for Human Cognition and Brain Science recently discovered that age-related bilateral decline in anti-phase movement is related to differences in alpha and beta neural activity .
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Researchers have discovered that carnivores may adjust their schedules to avoid each other
Time of Update: 2021-11-01
Nakabayashi said: "Information about the temporal activity patterns of animals is essential to assess the response to human disturbance and implement appropriate protective measures .
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Research reveals potential new ways to fight urinary tract infections
Time of Update: 2021-11-01
Mysorekar said: "Through the UTI animal model, we proved that DMF can activate NRF2, suppress the immune response, limit the damage caused by bacteria to urothelial cells, and promote the activation of RAB27B, thereby removing bacteria from the bladder .
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PNAS: The clearest structure diagram of live E. coli so far released
Time of Update: 2021-11-01
The resulting molecular structure image on the surface of the bacteria shows that the entire outer membrane of the bacteria is packed with micropores formed by proteins that allow nutrients to enter but prevent toxins from entering .
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Science Advances: A protein food can prevent dementia
Time of Update: 2021-11-01
In a study recently published in the journal Science Advances, Japanese researchers showed that a low-protein diet can accelerate brain degeneration in a mouse model of Alzheimer's disease .
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Science Immunology challenges the original theory: the mechanism of action of ineffective drugs for psoriasis
Time of Update: 2021-11-01
The complex changes in the network of immune cells and the messengers they use to communicate with each other are responsible for the development of skin diseases .
In fact, as the researchers discovered, the recognition of interleukin-12 by these skin cells is responsible for the protection of the messenger .
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Science subverts cognition!
Time of Update: 2021-11-01
Now, a new study led by researchers from Pompeo Fabra University/Spanish National Cardiovascular Research Center (CNIC) and Portuguese iMM, published in the " Science " magazine on October 15th , describes a method that relies on muscle fiber nuclear weight It is a new mechanism of muscle repair independent of the physiological damage of muscle stem cells .
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Science: Looking at cancer from the perspective of DNA
Time of Update: 2021-11-01
"We will discuss cancer from a single gene protein, let's see how we see patients with different mutations affect the same protein function," Ideker said, noting that this work represents the ability of new technology to explain the impact of mutations in a more precise way .
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How diet affects tumors
Time of Update: 2021-11-01
A new study from the Massachusetts Institute of Technology analyzed two different diets in mice, revealing how these diets affect cancer cells and providing an explanation for why calorie restriction can slow tumor growth .
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Dupixent is expected to gain a new indication for the treatment of prurigo nodularis to reach the phase 3 clinical endpoint
Time of Update: 2021-11-01
On October 22, 2021, Regeneron and Sanofi announced that dupilumab injection (dupilumab, English trade name Dupixent) is used in the treatment of adult patients with poorly controlled prurigo nodularis In the pivotal phase 3 clinical trial, the primary and all key secondary endpoints were met .
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Nature puts forward a new view of molecular switches: the mystery of how cells complete complex tasks
Time of Update: 2021-11-01
A study by the Quantitative Biological Sciences Institute (QBI) of the University of California, San Francisco, published in the October 13th issue of Nature, discovered important details of a protein called a molecular switch that ensures The normal operation of these networks .
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Researchers publish new insights into how glioblastoma invades and grows
Time of Update: 2021-11-01
"Researchers have developed a method to generate syngeneic neural stem cells and use it as a comparator of patient-specific glioma starter cells to discover the pathogenesis-related mechanisms of glioblastoma and determine the patient’s risk Drug targets .
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Research progress on the seagrass zone of Elytrigia longiflora
Time of Update: 2021-11-01
2020 Nian 1 month, Chinese Academy of Sciences, researcher at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Li Zhensheng proposed the use of saline Bohai planting salt-tolerant pasture establishment " coastal grass strip " idea .
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Seismic shear wave imaging reveals the characteristics of magmatic activity and crustal extension in the northeastern part of the South China Sea
Time of Update: 2021-11-01
Understanding the developmental scale, material attributes and structural models of magmatic activities in the northeastern South China Sea is of great significance to the study of regional tectonic evolution .
This study provides important information for in-depth understanding of magmatic activity and crustal extension in the northern continental margin of the South China Sea .
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Preliminary clinical trial results of innovative gene therapy to treat fatal childhood immunodeficiency are positive
Time of Update: 2021-11-01
A few days ago, Rocket Pharmaceuticals announced that its research gene therapy RP-L201 has obtained positive interim data in a phase 1/2 clinical trial for the treatment of leukocyte adhesion deficiency type I (LAD-I) .
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Depression and anxiety may be related to the risk of pregnant women's caesarean section
Time of Update: 2021-11-01
"Our findings emphasize the importance of better identifying and treating perinatal depression and anxiety disorders in pregnant women," said senior author Vanessa Dalton, MD, master of public health, obstetrician and gynecologist at the University of Michigan Health Von Voigtlander and Women's Hospital .
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Early accumulation of tau in the brain heralds memory decline in Alzheimer's disease patients
Time of Update: 2021-11-01
"There are different biomarkers in the rapid development of Alzheimer's disease in recent years, allowing us to measure and detect the early signs of the disease in patients," said Marco Bucci, the first author of the study, of the Alzheimer's Research Center.
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Phase 3 clinical results of Bayer's "first-in-class" therapy released
Time of Update: 2021-10-23
A few days ago, Bayer announced that its "first-in-class" therapy Kerendia (finerenone), a phase 3 clinical trial FIGARO-DKD in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) The primary end point was reached .
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The "anti-cancer weapon" they created has brought a safer life to countless women
Time of Update: 2021-10-23
He used the work left by studying EBV that year and contacted some colleagues to ask them to check whether the cervical cancer samples contained HSV-2 DNA, but the results given by the colleagues were negative .
Retrieved September 1st 2021 from https:// HPV vaccines for cancer prevention.
