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Picture: In inflamed skin, keratinocytes with interleukin-12 receptor (left picture) divide less than keratinocytes without this receptor (right picture)
Source: University of Zurich
Psoriasis is a chronic inflammatory autoimmune disease that manifests as red, scaly skin patches
The role of interleukin-12 in psoriasis
The research team of Burkhard Becher, Professor of Immunology and Team Leader Sarah Mundt from the UZH Institute of Experimental Immunology, systematically studied the role of interleukin-12 in psoriasis
Interleukin-12 maintains the normal function of skin cells
Detailed studies on mouse and human tissues have shown that various types of cells in the skin are also equipped with interleukin-12 receptors
Improve psoriasis treatment
"Our results show that blocking interleukin-12 is not advisable, so such drugs should no longer be used to treat patients with psoriasis," said Pascale Zwicky, the first author of the study and a doctoral student
The findings of UZH researchers may be important for the treatment of other diseases
Article title
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation
